Phase 2 Placebo-Controlled Study to Assess the Safety and Efficacy of ESK-001 in Active Systemic Lupus Erythematosus
Public ClinicalTrials.gov record NCT05966480. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Multicenter, Multinational, Randomized, Double-blind, Placebo-Controlled Study to Assess the Safety, Efficacy, and Pharmacokinetics of Multiple Dose Levels of ESK-001 in Adult Patients With Systemic Lupus Erythematosus
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to assess the clinical efficacy, safety, PK, and PD of multiple dose levels of ESK-001 compared with placebo in adult patients with SLE.
Study identification
- NCT ID
- NCT05966480
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 408 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 70 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 25, 2023
- Primary completion
- Jun 22, 2026
- Completion
- Aug 31, 2027
- Last update posted
- Jul 20, 2026
2023 – 2027
United States locations
- U.S. sites
- 48
- U.S. states
- 13
- U.S. cities
- 41
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Investigator Site #1046 | Anniston | Alabama | 36207 | — |
| Investigator Site #1104 | La Jolla | California | 92037 | — |
| Investigator Site #1050 | Los Alamitos | California | 90720 | — |
| Investigator Site #1168 | Mission Hills | California | 91345 | — |
| Investigator Site #1174 | Napa | California | 94558 | — |
| Investigator Site #1061 | Upland | California | 91786 | — |
| Investigator Site #1048 | Aventura | Florida | 33180 | — |
| Investigator Site #1063 | Avon Park | Florida | 33825 | — |
| Investigator Site #1176 | Bradenton | Florida | 34209 | — |
| Investigator Site #1045 | Clearwater | Florida | 33765 | — |
| Investigator Site #1055 | Coral Gables | Florida | 33134 | — |
| Investigator Site #1097 | Coral Springs | Florida | 33071 | — |
| Investigator Site #1091 | Daytona Beach | Florida | 32117 | — |
| Investigator Site #1051 | DeBary | Florida | 32713 | — |
| Investigator Site #1087 | Hollywood | Florida | 33020 | — |
| Investigator Site #1135 | Kissimmee | Florida | 34741 | — |
| Investigator Site #1060 | Miami | Florida | 33136 | — |
| Investigator Site #1093 | Miami | Florida | 33155 | — |
| Investigator Site #1057 | Miami | Florida | 33176 | — |
| Investigator Site #1067 | Miami Lakes | Florida | 33014 | — |
| Investigator Site #1090 | Plantation | Florida | 33324 | — |
| Investigator Site #1089 | Tampa | Florida | 33606 | — |
| Investigator Site #1170 | Atlanta | Georgia | 30328 | — |
| Investigator Site #1052 | College Park | Georgia | 30329 | — |
| Investigator Site #1204 | Chesterfield | Missouri | 63017 | — |
| Investigator site #1209 | Las Vegas | Nevada | 89102 | — |
| Investigator Site #1189 | Sparta | New Jersey | 07871 | — |
| Investigator Site #1101 | Albuquerque | New Mexico | 87102 | — |
| Investigator Site #1058 | Brooklyn | New York | 11201 | — |
| Investigator Site #1088 | New York | New York | 10032 | — |
| Investigator Site #1175 | Queens | New York | 11001 | — |
| Investigator Site #1095 | Charlotte | North Carolina | 28207 | — |
| Investigator Site #1056 | Charlotte | North Carolina | 28210 | — |
| Investigator Site #1173 | Charlotte | North Carolina | 28277 | — |
| Investigator Site #1171 | Philadelphia | Pennsylvania | 19114 | — |
| Investigator Site #1062 | Pittsburgh | Pennsylvania | 15224 | — |
| Investigator Site #1044 | Memphis | Tennessee | 38119 | — |
| Investigator Site #1195 | Carrollton | Texas | 75006 | — |
| Investigator Site #1049 | Colleyville | Texas | 76034 | — |
| Investigator Site #1071 | Fort Worth | Texas | 76177 | — |
| Investigator Site #1094 | Houston | Texas | 77054 | — |
| Investigator Site #1169 | Houston | Texas | 77095 | — |
| Investigator site #1178 | Houston | Texas | 77386 | — |
| Investigator Site #1187 | Red Oak | Texas | 75154 | — |
| Investigator site #1053 | San Antonio | Texas | 78215 | — |
| Investigator Site #1186 | San Antonio | Texas | 78229 | — |
| Investigator Site #1172 | Spring | Texas | 77388 | — |
| Investigator Site #1194 | Tomball | Texas | 77375 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 121 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05966480, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 20, 2026 · Synced Sep 28, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05966480 live on ClinicalTrials.gov.