ClinicalTrials.gov record
Recruiting Phase 3 Interventional

Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell Lymphoma

ClinicalTrials.gov ID: NCT05976763

Public ClinicalTrials.gov record NCT05976763. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced May 10, 2026, 3:22 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized Phase 3 Trial of Continuous vs. Intermittent Maintenance Therapy With Zanubrutinib as Upfront Treatment in Older Patients With Mantle Cell Lymphoma

Study identification

NCT ID
NCT05976763
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Alliance for Clinical Trials in Oncology
Other
Enrollment
421 participants

Conditions and interventions

Interventions

  • Biospecimen Collection Procedure
  • Bone Marrow Biopsy Procedure
  • Colonoscopy Procedure
  • Computed Tomography Procedure
  • Esophagogastroduodenoscopy Procedure
  • Fludeoxyglucose F-18 Other
  • Magnetic Resonance Imaging Procedure
  • Patient Observation Other
  • Positron Emission Tomography Procedure
  • Questionnaire Administration Other
  • Rituximab Biological
  • Zanubrutinib Drug

Procedure · Other · Biological + 1 more

Eligibility (public fields only)

Age range
60 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Oct 19, 2023
Primary completion
Aug 30, 2038
Completion
Aug 30, 2038
Last update posted
May 7, 2026

2023 – 2038

United States locations

U.S. sites
236
U.S. states
31
U.S. cities
186
Facility City State ZIP Site status
University of Arkansas for Medical Sciences Little Rock Arkansas 72205 Recruiting
Tower Cancer Research Foundation Beverly Hills California 90211 Recruiting
City of Hope Comprehensive Cancer Center Duarte California 91010 Active, not recruiting
City of Hope at Irvine Lennar Irvine California 92618 Active, not recruiting
Cedars-Sinai Medical Center Los Angeles California 90048 Recruiting
Smilow Cancer Hospital-Derby Care Center Derby Connecticut 06418 Recruiting
Smilow Cancer Hospital Care Center-Fairfield Fairfield Connecticut 06824 Recruiting
Smilow Cancer Hospital Care Center at Glastonbury Glastonbury Connecticut 06033 Recruiting
Smilow Cancer Hospital Care Center at Greenwich Greenwich Connecticut 06830 Recruiting
Smilow Cancer Hospital Care Center - Guilford Guilford Connecticut 06437 Recruiting
Smilow Cancer Hospital Care Center at Saint Francis Hartford Connecticut 06105 Recruiting
Yale University New Haven Connecticut 06520 Recruiting
Yale-New Haven Hospital North Haven Medical Center North Haven Connecticut 06473 Recruiting
Smilow Cancer Hospital Care Center at Long Ridge Stamford Connecticut 06902 Recruiting
Smilow Cancer Hospital-Torrington Care Center Torrington Connecticut 06790 Recruiting
Smilow Cancer Hospital Care Center-Trumbull Trumbull Connecticut 06611 Recruiting
Smilow Cancer Hospital-Waterbury Care Center Waterbury Connecticut 06708 Recruiting
Smilow Cancer Hospital Care Center - Waterford Waterford Connecticut 06385 Recruiting
Helen F Graham Cancer Center Newark Delaware 19713 Recruiting
Medical Oncology Hematology Consultants PA Newark Delaware 19713 Recruiting
Phoebe Putney Memorial Hospital Albany Georgia 31701 Recruiting
Grady Health System Atlanta Georgia 30303 Recruiting
Emory University Hospital Midtown Atlanta Georgia 30308 Recruiting
Emory University Hospital/Winship Cancer Institute Atlanta Georgia 30322 Recruiting
Emory Saint Joseph's Hospital Atlanta Georgia 30342 Recruiting
Augusta University Medical Center Augusta Georgia 30912 Recruiting
Emory Johns Creek Hospital Johns Creek Georgia 30097 Recruiting
Saint Alphonsus Cancer Care Center-Boise Boise Idaho 83706 Recruiting
Saint Luke's Cancer Institute - Boise Boise Idaho 83712 Recruiting
Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho 83605 Recruiting
Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho 83814 Recruiting
Saint Luke's Cancer Institute - Fruitland Fruitland Idaho 83619 Recruiting
Saint Luke's Cancer Institute - Meridian Meridian Idaho 83642 Recruiting
Saint Alphonsus Cancer Care Center-Nampa Nampa Idaho 83687 Recruiting
Saint Luke's Cancer Institute - Nampa Nampa Idaho 83687 Recruiting
Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho 83854 Recruiting
Kootenai Clinic Cancer Services - Sandpoint Sandpoint Idaho 83864 Recruiting
Illinois CancerCare-Bloomington Bloomington Illinois 61704 Recruiting
Illinois CancerCare-Canton Canton Illinois 61520 Recruiting
Illinois CancerCare-Carthage Carthage Illinois 62321 Recruiting
Alliance for Clinical Trials in Oncology Chicago Illinois 60606 Recruiting
University of Illinois Chicago Illinois 60612 Recruiting
Carle at The Riverfront Danville Illinois 61832 Recruiting
Cancer Care Specialists of Illinois - Decatur Decatur Illinois 62526 Recruiting
Decatur Memorial Hospital Decatur Illinois 62526 Recruiting
Illinois CancerCare-Dixon Dixon Illinois 61021 Recruiting
Carle Physician Group-Effingham Effingham Illinois 62401 Recruiting
Crossroads Cancer Center Effingham Illinois 62401 Recruiting
Illinois CancerCare-Eureka Eureka Illinois 61530 Recruiting
Illinois CancerCare-Galesburg Galesburg Illinois 61401 Recruiting
Illinois CancerCare-Kewanee Clinic Kewanee Illinois 61443 Recruiting
Illinois CancerCare-Macomb Macomb Illinois 61455 Recruiting
Carle Physician Group-Mattoon/Charleston Mattoon Illinois 61938 Recruiting
Cancer Care Center of O'Fallon O'Fallon Illinois 62269 Recruiting
Illinois CancerCare-Ottawa Clinic Ottawa Illinois 61350 Recruiting
Illinois CancerCare-Pekin Pekin Illinois 61554 Recruiting
Illinois CancerCare-Peoria Peoria Illinois 61615 Recruiting
Illinois CancerCare-Peru Peru Illinois 61354 Recruiting
Illinois CancerCare-Princeton Princeton Illinois 61356 Recruiting
Memorial Hospital East Shiloh Illinois 62269 Recruiting
Southern Illinois University School of Medicine Springfield Illinois 62702 Recruiting
Springfield Clinic Springfield Illinois 62702 Recruiting
Springfield Memorial Hospital Springfield Illinois 62781 Recruiting
Carle Cancer Center Urbana Illinois 61801 Recruiting
Illinois CancerCare - Washington Washington Illinois 61571 Recruiting
Northwest Cancer Center - Crown Point Crown Point Indiana 46307 Recruiting
Northwest Oncology LLC Dyer Indiana 46311 Recruiting
Northwest Cancer Center - Hobart Hobart Indiana 46342 Recruiting
Saint Mary Medical Center Hobart Indiana 46342 Recruiting
Saint Catherine Hospital Indianapolis Indiana 46312 Recruiting
The Community Hospital Munster Indiana 46321 Recruiting
Women's Diagnostic Center - Munster Munster Indiana 46321 Recruiting
Northwest Cancer Center - Valparaiso Valparaiso Indiana 46383 Recruiting
Mary Greeley Medical Center Ames Iowa 50010 Recruiting
McFarland Clinic - Ames Ames Iowa 50010 Recruiting
UI Health Care Mission Cancer and Blood - Ankeny Clinic Ankeny Iowa 50023 Recruiting
McFarland Clinic - Boone Boone Iowa 50036 Suspended
Saint Anthony Regional Hospital Carroll Iowa 51401 Recruiting
UI Health Care Mission Cancer and Blood - West Des Moines Clinic Clive Iowa 50325 Recruiting
Iowa Methodist Medical Center Des Moines Iowa 50309 Recruiting
UI Health Care Mission Cancer and Blood - Des Moines Clinic Des Moines Iowa 50309 Recruiting
Broadlawns Medical Center Des Moines Iowa 50314 Recruiting
Mercy Medical Center - Des Moines Des Moines Iowa 50314 Recruiting
UI Health Care Mission Cancer and Blood - Laurel Clinic Des Moines Iowa 50314 Recruiting
McFarland Clinic - Trinity Cancer Center Fort Dodge Iowa 50501 Recruiting
UI Healthcare Mission Cancer and Blood - Fort Dodge Fort Dodge Iowa 50501 Recruiting
University of Iowa/Holden Comprehensive Cancer Center Iowa City Iowa 52242 Recruiting
McFarland Clinic - Jefferson Jefferson Iowa 50129 Suspended
McFarland Clinic - Marshalltown Marshalltown Iowa 50158 Recruiting
UI Health Care Mission Cancer and Blood - Waukee Clinic Waukee Iowa 50263 Recruiting
HaysMed Hays Kansas 67601 Recruiting
University of Kansas Cancer Center Kansas City Kansas 66160 Recruiting
Lawrence Memorial Hospital Lawrence Kansas 66044 Recruiting
Veteran Administration Eastern Kansas Healthcare Leavenworth Kansas 66048 Recruiting
The University of Kansas Cancer Center - Olathe Olathe Kansas 66061 Recruiting
University of Kansas Cancer Center-Overland Park Overland Park Kansas 66210 Recruiting
Freeman Physician Group of Pittsburg Pittsburg Kansas 66762 Suspended
Salina Regional Health Center Salina Kansas 67401 Recruiting
University of Kansas Health System Saint Francis Campus Topeka Kansas 66606 Recruiting
University of Kansas Hospital-Westwood Cancer Center Westwood Kansas 66205 Recruiting
The James Graham Brown Cancer Center at University of Louisville Louisville Kentucky 40202 Recruiting
UofL Health Medical Center Northeast Louisville Kentucky 40245 Recruiting
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor Michigan 48106 Recruiting
McLaren Cancer Institute-Bay City Bay City Michigan 48706 Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan 48114 Recruiting
Trinity Health Medical Center - Brighton Brighton Michigan 48114 Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan 48188 Recruiting
Trinity Health Medical Center - Canton Canton Michigan 48188 Recruiting
Chelsea Hospital Chelsea Michigan 48118 Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan 48118 Recruiting
McLaren Cancer Institute-Clarkston Clarkston Michigan 48346 Recruiting
Wayne State University/Karmanos Cancer Institute Detroit Michigan 48201 Recruiting
Weisberg Cancer Treatment Center Farmington Hills Michigan 48334 Recruiting
Corewell Health Farmington Hills Hospital Farmington Hills Michigan 48336 Recruiting
Cancer Hematology Centers - Flint Flint Michigan 48503 Recruiting
Genesee Hematology Oncology PC Flint Michigan 48503 Suspended
Genesys Hurley Cancer Institute Flint Michigan 48503 Recruiting
Hurley Medical Center Flint Michigan 48503 Recruiting
McLaren Cancer Institute-Flint Flint Michigan 48532 Recruiting
University of Michigan Health - Sparrow Lansing Lansing Michigan 48912 Recruiting
McLaren Cancer Institute-Lapeer Region Lapeer Michigan 48446 Recruiting
Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan 48154 Recruiting
Henry Ford Saint John Hospital - Macomb Medical Macomb Michigan 48044 Recruiting
McLaren Cancer Institute-Central Michigan Mount Pleasant Michigan 48858 Recruiting
McLaren Cancer Institute-Northern Michigan Petoskey Michigan 49770 Recruiting
Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac Michigan 48341 Recruiting
Corewell Health William Beaumont University Hospital Royal Oak Michigan 48073 Recruiting
MyMichigan Medical Center Saginaw Saginaw Michigan 48601 Recruiting
Oncology Hematology Associates of Saginaw Valley PC Saginaw Michigan 48604 Suspended
MyMichigan Medical Center Tawas Tawas City Michigan 48764 Recruiting
Corewell Health Beaumont Troy Hospital Troy Michigan 48085 Recruiting
Saint Mary's Oncology/Hematology Associates of West Branch West Branch Michigan 48661 Suspended
Huron Gastroenterology PC Ypsilanti Michigan 48106 Recruiting
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan 48197 Recruiting
Sanford Joe Lueken Cancer Center Bemidji Minnesota 56601 Recruiting
Essentia Health Saint Joseph's Medical Center Brainerd Minnesota 56401 Recruiting
Mercy Hospital Coon Rapids Minnesota 55433 Recruiting
Essentia Health - Deer River Clinic Deer River Minnesota 56636 Recruiting
Essentia Health Cancer Center Duluth Minnesota 55805 Recruiting
Essentia Health Hibbing Clinic Hibbing Minnesota 55746 Recruiting
Saint John's Hospital - Healtheast Maplewood Minnesota 55109 Recruiting
Abbott-Northwestern Hospital Minneapolis Minnesota 55407 Recruiting
Hennepin County Medical Center Minneapolis Minnesota 55415 Recruiting
Coborn Cancer Center at Saint Cloud Hospital Saint Cloud Minnesota 56303 Recruiting
Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota 55416 Recruiting
Regions Hospital Saint Paul Minnesota 55101 Recruiting
United Hospital Saint Paul Minnesota 55102 Recruiting
Essentia Health Sandstone Sandstone Minnesota 55072 Recruiting
Essentia Health Virginia Clinic Virginia Minnesota 55792 Recruiting
Minnesota Oncology Hematology PA-Woodbury Woodbury Minnesota 55125 Recruiting
Saint Francis Medical Center Cape Girardeau Missouri 63703 Recruiting
Saint Luke's Hospital Chesterfield Missouri 63017 Recruiting
Siteman Cancer Center at Saint Peters Hospital City of Saint Peters Missouri 63376 Recruiting
Siteman Cancer Center at West County Hospital Creve Coeur Missouri 63141 Recruiting
University Health Truman Medical Center Kansas City Missouri 64108 Recruiting
University of Kansas Cancer Center - Briarcliff Kansas City Missouri 64116 Recruiting
Kansas City Veterans Affairs Medical Center Kansas City Missouri 64128 Recruiting
University of Kansas Cancer Center - North Kansas City Missouri 64154 Recruiting
University of Kansas Cancer Center - Lee's Summit Lee's Summit Missouri 64064 Recruiting
University of Kansas Cancer Center at North Kansas City Hospital North Kansas City Missouri 64116 Suspended
Mercy Hospital Springfield Springfield Missouri 65804 Recruiting
CoxHealth South Hospital Springfield Missouri 65807 Recruiting
Washington University School of Medicine St Louis Missouri 63110 Recruiting
Mercy Hospital South St Louis Missouri 63128 Recruiting
Siteman Cancer Center-South County St Louis Missouri 63129 Recruiting
Siteman Cancer Center at Christian Hospital St Louis Missouri 63136 Recruiting
Community Hospital of Anaconda Anaconda Montana 59711 Recruiting
Billings Clinic Cancer Center Billings Montana 59101 Recruiting
Bozeman Health Deaconess Hospital Bozeman Montana 59715 Recruiting
Benefis Sletten Cancer Institute Great Falls Montana 59405 Recruiting
Logan Health Medical Center Kalispell Montana 59901 Recruiting
Community Medical Center Missoula Montana 59804 Recruiting
Nebraska Medicine-Bellevue Bellevue Nebraska 68123 Recruiting
Nebraska Medicine-Village Pointe Omaha Nebraska 68118 Recruiting
University of Nebraska Medical Center Omaha Nebraska 68198 Recruiting
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center Lebanon New Hampshire 03756 Recruiting
Roswell Park Cancer Institute Buffalo New York 14263 Recruiting
Hematology Oncology Associates of CNY at Camillus Camillus New York 13031 Recruiting
Hematology Oncology Associates of Central New York-East Syracuse East Syracuse New York 13057 Recruiting
NYU Langone Hospital - Long Island Mineola New York 11501 Recruiting
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York New York 10016 Recruiting
NYP/Weill Cornell Medical Center New York New York 10065 Recruiting
University of Rochester Rochester New York 14642 Recruiting
Wilmot Cancer Institute at Webster Webster New York 14580 Recruiting
UNC Lineberger Comprehensive Cancer Center Chapel Hill North Carolina 27599 Recruiting
Duke University Medical Center Durham North Carolina 27710 Recruiting
Sanford Bismarck Medical Center Bismarck North Dakota 58501 Recruiting
Essentia Health Cancer Center-South University Clinic Fargo North Dakota 58103 Recruiting
Sanford Broadway Medical Center Fargo North Dakota 58122 Recruiting
Sanford Roger Maris Cancer Center Fargo North Dakota 58122 Recruiting
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210 Recruiting
Cancer Centers of Southwest Oklahoma Research Lawton Oklahoma 73505 Recruiting
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 Recruiting
Oklahoma Cancer Specialists and Research Institute-Tulsa Tulsa Oklahoma 74146 Recruiting
Providence Newberg Medical Center Newberg Oregon 97132 Recruiting
Saint Alphonsus Cancer Care Center-Ontario Ontario Oregon 97914 Recruiting
Providence Willamette Falls Medical Center Oregon City Oregon 97045 Recruiting
Providence Portland Medical Center Portland Oregon 97213 Recruiting
Providence Saint Vincent Medical Center Portland Oregon 97225 Recruiting
Rhode Island Hospital Providence Rhode Island 02903 Recruiting
Smilow Cancer Hospital Care Center - Westerly Westerly Rhode Island 02891 Recruiting
Prisma Health Cancer Institute - Spartanburg Boiling Springs South Carolina 29316 Recruiting
Medical University of South Carolina Charleston South Carolina 29425 Recruiting
Prisma Health Cancer Institute - Easley Easley South Carolina 29640 Recruiting
Prisma Health Cancer Institute - Butternut Greenville South Carolina 29605 Recruiting
Prisma Health Cancer Institute - Faris Greenville South Carolina 29605 Recruiting
Prisma Health Cancer Institute - Eastside Greenville South Carolina 29615 Recruiting
Prisma Health Cancer Institute - Greer Greer South Carolina 29650 Recruiting
Prisma Health Cancer Institute - Seneca Seneca South Carolina 29672 Recruiting
Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota 57104 Recruiting
Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota 57117-5134 Recruiting
Huntsman Cancer Institute/University of Utah Salt Lake City Utah 84112 Recruiting
Dartmouth Cancer Center - North Saint Johnsbury Vermont 05819 Recruiting
VCU Massey Cancer Center at Stony Point Richmond Virginia 23235 Recruiting
VCU Massey Comprehensive Cancer Center Richmond Virginia 23298 Recruiting
Swedish Cancer Institute-Edmonds Edmonds Washington 98026 Recruiting
Swedish Cancer Institute-Issaquah Issaquah Washington 98029 Recruiting
Swedish Medical Center-First Hill Seattle Washington 98122 Recruiting
ThedaCare Regional Cancer Center Appleton Wisconsin 54911 Recruiting
ThedaCare Regional Medical Center - Appleton Appleton Wisconsin 54911 Recruiting
Duluth Clinic Ashland Ashland Wisconsin 54806 Recruiting
Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin 54701 Recruiting
University of Wisconsin Carbone Cancer Center - Johnson Creek Johnson Creek Wisconsin 53038 Recruiting
Gundersen Lutheran Medical Center La Crosse Wisconsin 54601 Recruiting
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center Madison Wisconsin 53718 Recruiting
University of Wisconsin Carbone Cancer Center - University Hospital Madison Wisconsin 53792 Recruiting
Marshfield Medical Center-Marshfield Marshfield Wisconsin 54449 Recruiting
Medical College of Wisconsin Milwaukee Wisconsin 53226 Recruiting
Marshfield Medical Center - Minocqua Minocqua Wisconsin 54548 Recruiting
ProHealth D N Greenwald Center Mukwonago Wisconsin 53149 Recruiting
Froedtert and MCW Moorland Reserve Health Center New Berlin Wisconsin 53151 Recruiting
ProHealth Oconomowoc Memorial Hospital Oconomowoc Wisconsin 53066 Recruiting
Marshfield Medical Center-Rice Lake Rice Lake Wisconsin 54868 Recruiting
Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin 54482 Recruiting
UW Cancer Center at ProHealth Care Waukesha Wisconsin 53188 Recruiting
Marshfield Medical Center - Weston Weston Wisconsin 54476 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05976763, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted May 7, 2026 · Synced May 10, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05976763 live on ClinicalTrials.gov.

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