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Recruiting Not applicable Interventional

Hyperbaric Oxygen Therapy for Ulcerative Colitis (HBOT-UC)

ClinicalTrials.gov ID: NCT05987852

Public ClinicalTrials.gov record NCT05987852. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 5, 2026, 5:43 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Hyperbaric Oxygen Therapy for Ulcerative Colitis Patients Hospitalized for Moderate to Severe Flares: A Multi-Center, Randomized, Double-Blind, Sham-Controlled Trial

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

Chronic intestinal hypoxia and accompanying mucosal inflammation is a hallmark of ulcerative colitis (UC). Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen under increased atmospheric pressure to increase tissue oxygenation. Two small prospective randomized controlled trials have demonstrated that the delivery of HBOT to UC patients hospitalized for acute moderate to severe flares results in improved remission rates and avoidance of in-hospital progression to biologics, small molecules, or colectomy. In this larger trial the study aims to confirm the treatment benefits of HBOT for hospitalized UC patients and study the immune-microbe mechanisms underpinning treatment response.

Study identification

NCT ID
NCT05987852
Recruitment status
Recruiting
Study type
Interventional
Phase
Not applicable
Lead sponsor
Northwestern University
Other
Enrollment
126 participants

Conditions and interventions

Interventions

Device · Other

Eligibility (public fields only)

Age range
18 Years to 85 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jan 8, 2024
Primary completion
Aug 31, 2027
Completion
Aug 31, 2027
Last update posted
Jan 7, 2026

2024 – 2027

United States locations

U.S. sites
13
U.S. states
10
U.S. cities
12
Facility City State ZIP Site status
University of Alabama Medicine Birmingham Alabama 35233 Recruiting
University of Los Angeles Health Los Angeles California 90024 Recruiting
University of Miami Health Miami Florida 33136 Recruiting
Orlando Health Orlando Florida 32806 Recruiting
Northwestern Medicine Lake Forest Hospital Lake Forest Illinois 60045 Recruiting
University of Louisville Louisville Kentucky 40202 Recruiting
Massachusetts General Hospital Boston Massachusetts 02114 Recruiting
Mayo Clinic Rochester Minnesota 55905 Recruiting
Dartmouth Hitchcock Medical Center Lebanon New Hampshire 03756 Recruiting
Cornell University Medical Center New York New York 10065 Active, not recruiting
State University of New York Upstate Medical University Syracuse New York 13210 Recruiting
Allegheny Health Pittsburgh Pennsylvania 15090 Recruiting
University of Pittsburgh Medical Center Pittsburgh Pennsylvania 15213 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05987852, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jan 7, 2026 · Synced Sep 5, 2026

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The complete protocol, eligibility criteria, and contact information for NCT05987852 live on ClinicalTrials.gov.

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