A Study To Learn About Two Study Medicines (PF-07275315 And PF-07264660) In People Who Have Moderate To Severe Atopic Dermatitis
Public ClinicalTrials.gov record NCT05995964. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO INVESTIGATE THE EFFICACY AND SAFETY OF PF-07275315 AND PF-07264660 IN ADULT PARTICIPANTS WITH MODERATE-SEVERE ATOPIC DERMATITIS
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to learn about the safety and effects of 2 study medicines (PF-07275315 and PF-07264660) for the treatment of atopic dermatitis (AD). AD is a long- lasting itchy red rash, caused by a skin reaction. This study is seeking participants who: * are 18 years of age or more. * Were confirmed to have AD at least 6 months ago. * Are not having an effective treatment result from medicines that are applied on skin for AD. * Are considered by their doctors to have moderate to severe AD. In Stage 1 of the study, participants will receive either PF-07275315 or PF-07264660 or placebo. Stage 1 is complete. In Stage 2 of the study participants will receive either PF-07275315 or placebo. In Stage 3 of the study participants who have received anti-inflammatory proteins, will receive either PF-07275315 or placebo. In Stage 4 of the study participants will receive either PF-07264660 or placebo. A placebo does not have any medicine in it but looks just like the medicines being studied. PF-07275315 or PF-07264660 or placebo will be given as multiple shots in the clinic over the course of each Stage. The experiences of people receiving PF-07275315 or PF-07264660 will be compared to people who do not. This will help determine if PF-07275315 and PF-07264660 are safe and effective. Participants in Stages 1, 2 and 4 will be involved in this study for up to 40 weeks (10 months). Participants in Stage 3 will be involved in this study for up to 52 weeks (13 months).
Study identification
- NCT ID
- NCT05995964
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 507 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 22, 2023 (Actual)
- Primary completion
- Nov 12, 2026 (Estimated)
- Completion
- Apr 1, 2027 (Estimated)
- Last update posted
- Oct 23, 2026
2023 – 2027
United States locations
- U.S. sites
- 50
- U.S. states
- 19
- U.S. cities
- 45
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Allervie Clinical Research | Birmingham | Alabama | 35209 | — |
| Onyx Clinical Research - Peoria | Peoria | Arizona | 85381 | — |
| Onyx Clinical Research | Phoenix | Arizona | 85050 | — |
| Banner - University Medicine Dermatology Clinic | Tucson | Arizona | 85718 | — |
| Marvel Clinical Research | Huntington Beach | California | 92647 | — |
| California Allergy and Asthma Medical Group | Los Angeles | California | 90025 | — |
| University Dermatology Trials, INC. | Newport Beach | California | 92660 | — |
| Northridge Clinical Trials | Northridge | California | 91325 | — |
| Profound Research LLC | Oceanside | California | 92056 | — |
| Dermatology Cosmetic Laser Medical Associates of La Jolla, Inc. | San Diego | California | 92121 | — |
| West Dermatology La Jolla | San Diego | California | 92121 | — |
| Sunwise Clinical Research | Walnut Creek | California | 94596 | — |
| AboutSkin Research, LLC | Greenwood Village | Colorado | 80111 | — |
| Renaissance Research and Medical Group | Cape Coral | Florida | 33991 | — |
| Florida International Medical Research | Coral Gables | Florida | 33134 | — |
| Revival Research | Doral | Florida | 33122 | — |
| St. Jude Clinical Research | Doral | Florida | 33172 | — |
| SouthCoast Research Center | Miami | Florida | 33136 | — |
| Floridian Research Institute Llc | Miami | Florida | 33179 | — |
| Global Health Research Center, Inc. | Miami Lakes | Florida | 33016 | — |
| Ziaderm Research LLC | North Miami Beach | Florida | 33162 | — |
| Clinical Neuroscience Solutions, Inc. | Orlando | Florida | 32801 | — |
| GCP Research, Global Clinical professionals | St. Petersburg | Florida | 33714 | — |
| ForCare Clinical Research | Tampa | Florida | 33613 | — |
| Dawes Fretzin Clinical Research Group, LLC | Indianapolis | Indiana | 46250 | — |
| Southern Indiana Clinical Trials | New Albany | Indiana | 47150 | — |
| Maryland Laser Skin and Vein | Hunt Valley | Maryland | 21030 | — |
| Michigan Center for Research Company | Clarkston | Michigan | 48346 | — |
| MI Skin Innovations | Northville | Michigan | 48167 | — |
| Revival Research Institute LLC | Troy | Michigan | 48084 | — |
| Skin Specialists, PC dba Schlessinger MD | Omaha | Nebraska | 68144 | — |
| Empire Dermatology | East Syracuse | New York | 13057 | — |
| Private Practice - Dr. Bobby Buka | New York | New York | 10012 | — |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | — |
| Sadick Research Group | New York | New York | 10075 | — |
| Apex Clinical Research Center | Mayfield Heights | Ohio | 44124 | — |
| Epic Medical Research - Oklahoma | Chickasha | Oklahoma | 73018 | — |
| Unity Clinical Research | Oklahoma City | Oklahoma | 73118 | — |
| Vital Prospects Clinical Research Institute, PC | Tulsa | Oklahoma | 74136 | — |
| Velocity Clinical Research, Medford | Medford | Oregon | 97504 | — |
| Paddington Testing Co, Inc | Philadelphia | Pennsylvania | 19103 | — |
| Clinical Partners, LLC | Johnston | Rhode Island | 02919 | — |
| Spartanburg Medical Research | Spartanburg | South Carolina | 29303 | — |
| Clinical Neuroscience Solutions Inc. | Memphis | Tennessee | 38119 | — |
| Dermatology Treatment and Research Center | Dallas | Texas | 75230 | — |
| North Texas Center for Clinical Research | Frisco | Texas | 75034 | — |
| Alpesh D. Desai, DO PLLC | Houston | Texas | 77008 | — |
| DCT-Stone Oak, LLC dba Discovery Clinical Trials | San Antonio | Texas | 78258 | — |
| Complete Dermatology | Sugar Land | Texas | 77479 | — |
| Virginia Dermatology and Skin Cancer Center | Norfolk | Virginia | 23502 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 46 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05995964, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 23, 2026 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05995964 live on ClinicalTrials.gov.