TRADE: Dose Escalation Tolerability of Abemaciclib in HR+ HER2- Early Stage Breast Cancer
Public ClinicalTrials.gov record NCT06001762. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
The TRADE Study: A Phase 2 Trial to Assess the ToleRability of Abemaciclib Dose Escalation in Patients With Early-Stage HR-positive and HER2-negative Breast Cancer
Study identification
- NCT ID
- NCT06001762
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Dana-Farber Cancer Institute
- Other
- Enrollment
- 90 participants
Conditions and interventions
Interventions
- Abemaciclib Drug
- Tamoxifen Drug
- Anastrozole Drug
- Letrozole Drug
- Exemestane Drug
- LHRH Agonist Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 4, 2023
- Primary completion
- Jan 21, 2025
- Completion
- Dec 31, 2026
- Last update posted
- Jul 1, 2026
2023 – 2027
United States locations
- U.S. sites
- 12
- U.S. states
- 4
- U.S. cities
- 10
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Stamford Hospital | Stamford | Connecticut | 06904 | — |
| Eastern Maine Medical Center (Northern Light) | Brewer | Maine | 04412 | — |
| New England Cancer Specialists | Scarborough | Maine | 04074 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| Dana-Farber Cancer Institute at Steward St. Elizabeth's | Brighton | Massachusetts | 02135 | — |
| Dana-Farber Cancer Institute at Foxborough | Foxborough | Massachusetts | 02035 | — |
| Dana-Farber Cancer Institute at Merrimack Valley | Methuen | Massachusetts | 01844 | — |
| Dana-Farber Cancer Institute at Milford | Milford | Massachusetts | 01757 | — |
| Dana-Farber Cancer Institute at South Shore | South Weymouth | Massachusetts | 02190 | — |
| Dana-Farber Cancer Insitute at Londonderry Hospital | Londonderry | New Hampshire | 03053 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06001762, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 1, 2026 · Synced Jul 23, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06001762 live on ClinicalTrials.gov.