Early Parkinson's Disease Monotherapy With CVN424
Public ClinicalTrials.gov record NCT06006247. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled Trial of CVN424 in Early Parkinson's Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a multicenter, 12-week, placebo-controlled clinical trial of CVN424 150 milligrams (mg) tablets in early, untreated Parkinson's Disease (PD). Participants will be randomized in a 1:1 ratio to CVN424 150 mg or placebo at the Baseline Visit. The purpose of this study is to measure effect on motor features with CVN424 tablets compared to placebo in early, untreated PD and to evaluate the potential of CVN424 to improve motor and non-motor functions in participants with early PD who are not taking dopaminergic or anti-PD therapies.
Study identification
- NCT ID
- NCT06006247
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 64 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 30 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 11, 2023 (Actual)
- Primary completion
- Jan 30, 2025 (Actual)
- Completion
- Feb 13, 2025 (Actual)
- Last update posted
- Mar 23, 2026
2023 – 2025
United States locations
- U.S. sites
- 42
- U.S. states
- 20
- U.S. cities
- 32
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35233 | — |
| Barrow Neurological Institute | Phoenix | Arizona | 85013 | — |
| St Joseph's Hospital and Medical Center | Phoenix | Arizona | 85013 | — |
| Muhammad Ali Parkinson Center | Phoenix | Arizona | 85326 | — |
| Movement Disorders Center of Arizona, LLC | Scottsdale | Arizona | 85258 | — |
| Parkinson's Research Centers of America - Palo Alto | Palo Alto | California | 94301 | — |
| CenExel Rocky Mountain Clinical Research | Englewood | Colorado | 80113 | — |
| Parkinson's Disease and Movement Disorders Center of Boca Raton | Boca Raton | Florida | 33486 | — |
| SFM Clinical Research, LLC | Boca Raton | Florida | 33487 | — |
| N1 Research LLC | Orlando | Florida | 32825 | — |
| Parkinson's Disease Treatment Center of SWFL | Port Charlotte | Florida | 33980 | — |
| University of South Florida Parkinson's Disease and Movement Disorders Center | Tampa | Florida | 33613 | — |
| Augusta University | Augusta | Georgia | 30912 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| University of Kentucky, Dept of Neurology Kentucky Neuroscience Institute Research | Lexington | Kentucky | 40536-0284 | — |
| University of Kentucky, Center for Clinical and Translational Sciences | Lexington | Kentucky | 40536 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| University of Michigan Hospital / Michigan Clinical Research Unit (MCRU) Cardiovascular Center | Ann Arbor | Michigan | 48109-5872 | — |
| University of Michigan Department of Neurology | Ann Arbor | Michigan | 48109 | — |
| Quest Research Institute | Farmington Hills | Michigan | 48334 | — |
| Struthers Parkinson's Center | Golden Valley | Minnesota | 55427 | — |
| Albany Medical Center | Albany | New York | 12208 | — |
| Parkinson's Research Centers of America - Long Island | Commack | New York | 11725 | — |
| Weill Cornell Medicine | New York | New York | 10021 | — |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | — |
| Duke University Medical Center | Durham | North Carolina | 27705 | — |
| Riverhills Healthcare, Inc dba Riverhills Neuroscience | Cincinnati | Ohio | 45212 | — |
| The Ohio State University Department of Neurology - Madden Center for Parkinson Disease and Other Movement Disorders | Columbus | Ohio | 43210 | — |
| The Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | — |
| Martha Morehouse Medical Plaza | Columbus | Ohio | 43221 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| Veracity Neuroscience | Memphis | Tennessee | 38157 | — |
| Horizon Clinical Research Group | Cypress | Texas | 77429 | — |
| Texas Movement Disorder Specialists, PLLC | Georgetown | Texas | 78628 | — |
| Gill Neuroscience | Houston | Texas | 77065 | — |
| Central Texas Neurology Consultants | Round Rock | Texas | 78681 | — |
| Inova Neurology - Fairfax | Fairfax | Virginia | 22031 | — |
| Inova Fairfax Medical Campus | Falls Church | Virginia | 22042 | — |
| EvergreenHealth Neuroscience Institute | Kirkland | Washington | 98034 | — |
| EvergreenHealth Research Department | Kirkland | Washington | 98034 | — |
| Froedtert Hospital Department of Neurology | Milwaukee | Wisconsin | 53226 | — |
| Medical College of Wisconsin Department of Neurology | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06006247, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 23, 2026 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06006247 live on ClinicalTrials.gov.