A Study of SGN-B6A Versus Docetaxel in Previously Treated Non-small Cell Lung Cancer
Public ClinicalTrials.gov record NCT06012435. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A RANDOMIZED, PHASE 3, OPEN-LABEL STUDY TO EVALUATE SIGVOTATUG VEDOTIN COMPARED WITH DOCETAXEL IN ADULT PARTICIPANTS WITH PREVIOUSLY TREATED NON-SMALL CELL LUNG CANCER (BE6A LUNG-01)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This clinical trial is studying nonsquamous non-small cell lung cancer (NSCLC). Participants in this study must have cancer that has spread through their body or can't be removed with surgery. Participants in this study must have been treated with no more than a platinum-based chemotherapy and an anti-PD-(L)1 drug. Participants with tumors that have certain treatable genomic alterations must have had at least 1 drug for that genomic alteration, in addition to platinum-based chemotherapy. This clinical trial uses an experimental drug called sigvotatug vedotin, which is a type of antibody drug conjugate or ADC. ADCs are designed to stick to cancer cells and kill them. This clinical trial also uses a drug called docetaxel. Docetaxel is an anticancer drug that has been approved to treat non-small cell lung cancer. It is usually given to patients who previously received another anticancer treatment. In this study, one group of participants will get sigvotatug vedotin on Days 1 and 15 during each 28-day-cycle. A second group of participants will get docetaxel on Day 1 during each 21-day cycle. This study is being done to see if sigvotatug vedotin works better than docetaxel to treat participants with NSCLC. This study will also test what side effects happen when participants take these drugs. A side effect is anything a drug does to the body besides treating the disease.
Study identification
- NCT ID
- NCT06012435
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 762 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 21, 2024 (Actual)
- Primary completion
- May 18, 2026 (Actual)
- Completion
- May 17, 2028 (Estimated)
- Last update posted
- Jul 23, 2026
2024 – 2028
United States locations
- U.S. sites
- 130
- U.S. states
- 20
- U.S. cities
- 94
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alaska Oncology and Hematology, LLC | Anchorage | Alaska | 99508 | — |
| Providence Medical Foundation | Fullerton | California | 92835 | — |
| Providence St. Jude Medical Center Virginia K. Crosson Cancer Center and Infusion Center | Fullerton | California | 92835 | — |
| Providence St. Jude Medical Center | Fullerton | California | 92835 | — |
| Cancer and Blood Specialty Clinic | Los Alamitos | California | 90720 | — |
| Cancer Blood and Specialty Clinic | Los Alamitos | California | 90720 | — |
| Regulatory Management Only: TRIO-US Central Administration | Los Angeles | California | 90024 | — |
| Drug Management Only: UCLA West Medical Pharmacy Attn: Steven L. Wong, Pharma.D. | Los Angeles | California | 90095 | — |
| Drug Management Only: UCLA West Medical Pharmacy, Attn: Steven L Wong, Pharm.D. | Los Angeles | California | 90095 | — |
| UCSF Medical Center - Mission Bay | San Francisco | California | 94158 | — |
| Sansum Clinic | Santa Barbara | California | 93105 | — |
| Sansum Clinic | Solvang | California | 93463 | — |
| Rocky Mountain Cancer Centers LLP | Aurora | Colorado | 80012 | — |
| Rocky Mountain Cancer Centers LLP | Boulder | Colorado | 80303 | — |
| Rocky Mountain Cancer Centers LLP | Colorado Springs | Colorado | 80907 | — |
| Rocky Mountain Cancer Centers LLP | Colorado Springs | Colorado | 80923 | — |
| Rocky Mountain Cancer Centers LLP | Denver | Colorado | 80218 | — |
| Rocky Mountain Cancer Centers LLP | Denver | Colorado | 80220 | — |
| Rocky Mountain Cancer Centers LLP | Lakewood | Colorado | 80228 | — |
| Rocky Mountain Cancer Centers LLP | Littleton | Colorado | 80120 | — |
| Rocky Mountain Cancer Centers LLP | Lone Tree | Colorado | 80124 | — |
| Rocky Mountain Cancer Centers LLP | Longmont | Colorado | 80504 | — |
| Rocky Mountain Cancer Centers LLP | Pueblo | Colorado | 81003 | — |
| Rocky Mountain Cancer Centers LLP | Thornton | Colorado | 80260 | — |
| Cancer Specialists of North Florida | Fleming Island | Florida | 32003 | — |
| Cancer Specialists of North Florida | Jacksonville | Florida | 32204 | — |
| Cancer Specialists of North Florida | Jacksonville | Florida | 32218 | — |
| Cancer Specialists of North Florida | Jacksonville | Florida | 32256 | — |
| Cancer Specialists of North Florida | Jacksonville | Florida | 32258 | — |
| Cancer Care Centers of Brevard, Inc. | Melbourne | Florida | 32935 | — |
| Baptist Hospital of Miami | Miami | Florida | 33176 | — |
| Miami Cancer Institute at Baptist Health, Inc. | Miami | Florida | 33176 | — |
| Cancer Specialists of North Florida | Neptune Beach | Florida | 32266 | — |
| Cancer Care Centers of Brevard, Inc. | Palm Bay | Florida | 32901 | — |
| Cancer Care Centers of Brevard, Inc. | Rockledge | Florida | 32955 | — |
| Cancer Specialists of North Florida | Saint Augustine | Florida | 32086 | — |
| Illinois Cancer Specialists | Arlington Heights | Illinois | 60005 | — |
| Illinois Cancer Specialists | Niles | Illinois | 60714 | — |
| Maryland Oncology Hematology P.A. | Annapolis | Maryland | 21401 | — |
| Maryland Oncology Hematology P.A. | Bethesda | Maryland | 20817 | — |
| Maryland Oncology Hematology P.A. | Brandywine | Maryland | 20613 | — |
| Maryland Oncology Hematology P.A. | Columbia | Maryland | 21044 | — |
| Maryland Oncology Hematology P.A. | Germantown | Maryland | 20876 | — |
| Maryland Oncology Hematology P.A. | Largo | Maryland | 20774 | — |
| Maryland Oncology Hematology P.A. | Rockville | Maryland | 20850 | — |
| Maryland Oncology Hematology P.A. | Silver Spring | Maryland | 20904 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Southcoast Centers for Cancer Care | Fairhaven | Massachusetts | 02719 | — |
| Southcoast Centers for Cancer Care | Fall River | Massachusetts | 02720 | — |
| Allina Health Cancer Institute - Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Allina Health Cancer Institute - Abbott Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Allina Health Cancer Institute - United Hospital | Saint Paul | Minnesota | 55102 | — |
| Hattiesburg Clinic Hematology/Oncology. | Hattiesburg | Mississippi | 39401 | — |
| St Luke's Cancer Institute | Kansas City | Missouri | 64111 | — |
| Nebraska Medicine | Bellevue | Nebraska | 68123 | — |
| Nebraska Medicine | Omaha | Nebraska | 68105 | — |
| Nebraska Medicine | Omaha | Nebraska | 68118 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| Summit Medical Group | Florham Park | New Jersey | 07932 | — |
| NYU Langone Hospital - Long Island | Mineola | New York | 11501 | — |
| Perlmutter Cancer Center at NYU Langone Hospital - Long Island | Mineola | New York | 11501 | — |
| Laura & Isaac Perlmutter Cancer Center - NYU ACC | New York | New York | 10016 | — |
| Laura & Isaac Perlmutter Cancer Center at NYU Langone Health | New York | New York | 10016 | — |
| NYU Langone Medical Center (Tisch Hospital) | New York | New York | 10016 | — |
| University Hospitals Seidman Cancer Center at UH Avon Health Center | Avon | Ohio | 44011 | — |
| Oncology Hematology Care Clinical Trials, LLC | Cincinnati | Ohio | 45211 | — |
| Oncology Hematology Care Clinical Trials, LLC | Cincinnati | Ohio | 45242 | — |
| Oncology Hematology Care Clinical Trials, LLC | Cincinnati | Ohio | 45245 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic Cancer Center/Fairview Hospital Moll Cancer Pavilion | Cleveland | Ohio | 44111 | — |
| Oncology Hematology Care Clinical Trials, LLC | Fairfield | Ohio | 45014 | — |
| Taylor Cancer Research Center | Maumee | Ohio | 43537 | — |
| Cleveland Clinic Cancer Center/Hillcrest Hospital Cancer Center Pharmacy | Mayfield Heights | Ohio | 44124 | — |
| University Hospitals Seidman Cancer Center at UH Mentor Health Center | Mentor | Ohio | 44060 | — |
| UH Minoff Health Center at Chagrin Highlands | Orange | Ohio | 44122 | — |
| Oregon Health and Science University - CHO Beaverton | Beaverton | Oregon | 97006 | — |
| Oncology Associates of Oregon, P.C. | Eugene | Oregon | 97401 | — |
| Oregon Health and Science University - CHO Gresham | Gresham | Oregon | 97030 | — |
| Oregon Health and Science University - CHO Northwest | Portland | Oregon | 97210 | — |
| Northwest Cancer Specialists, P.C. | Portland | Oregon | 97213 | — |
| Oregon Health and Science University - CHO East Portland | Portland | Oregon | 97216 | — |
| Northwest Cancer Specialists, P.C. | Portland | Oregon | 97227 | — |
| Oregon Health and Science University (CHH1) | Portland | Oregon | 97239 | — |
| Oregon Health and Science University (CHH2) | Portland | Oregon | 97239 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Northwest Cancer Specialists, P.C. | Tigard | Oregon | 97223 | — |
| Oregon Health and Science University - CHO Tualatin | Tualatin | Oregon | 97062 | — |
| Alliance Cancer Specialists, PC | Bensalem | Pennsylvania | 19020 | — |
| Alliance Cancer Specialists, PC | Doylestown | Pennsylvania | 18901 | — |
| Alliance Cancer Specialists, PC | Horsham | Pennsylvania | 19044 | — |
| Alliance Cancer Specialists, PC | Langhorne | Pennsylvania | 19047 | — |
| Alliance Cancer Specialists, PC | Media | Pennsylvania | 19063 | — |
| Alliance Cancer Specialists, PC | Sellersville | Pennsylvania | 18960 | — |
| Alliance Cancer Specialists, PC | Wynnewood | Pennsylvania | 19096 | — |
| Texas Oncology - West Texas | Abilene | Texas | 79606 | — |
| Texas Oncology - West Texas | Amarillo | Texas | 79124 | — |
| Texas Oncology - Central South | Austin | Texas | 78705 | — |
| Texas Oncology - Central South | Austin | Texas | 78731 | — |
| Texas Oncology - Central South | Austin | Texas | 78745 | — |
| University of Texas Southwestern Medical Center - Simmons Cancer Center | Dallas | Texas | 75235 | — |
| UT Southwestern Medical Center - Redbird | Dallas | Texas | 75237 | — |
| Univ. of TX Southwestern Medical Center - Zale Lipshy University Hospital | Dallas | Texas | 75390 | — |
| University of Texas Southwestern Medical Center - William P. Clements, Jr., University Hospital | Dallas | Texas | 75390 | — |
| University Of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Texas Oncology - West Texas | El Paso | Texas | 79902 | — |
| Texas Oncology - West Texas | El Paso | Texas | 79915 | — |
| Texas Oncology - West Texas | El Paso | Texas | 79938 | — |
| UT Southwestern - Simmons Cancer Center - Fort Worth | Fort Worth | Texas | 76104 | — |
| US Oncology Investigational Product Center (IPC) | Irving | Texas | 75063 | — |
| US Oncology Investigational Products Center (IPC) | Irving | Texas | 75063 | — |
| Texas Oncology - West Texas | Midland | Texas | 79701 | — |
| Texas Oncology - West Texas | Odessa | Texas | 79761 | — |
| UT Southwestern - Simmons Cancer Center - Richardson/Plano | Richardson | Texas | 75080 | — |
| Texas Oncology - Central South | Waco | Texas | 76712 | — |
| Texas Oncology - West Texas | Wichita Falls | Texas | 76310 | — |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Blacksburg | Virginia | 24060 | — |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Low Moor | Virginia | 24457 | — |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Roanoke | Virginia | 24014 | — |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Salem | Virginia | 24153 | — |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Wytheville | Virginia | 24382 | — |
| Northwest Medical Specialties, PLLC | Bonney Lake | Washington | 98391 | — |
| Northwest Medical Specialties, PLLC | Federal Way | Washington | 98003 | — |
| Northwest Medical Specialties, PLLC | Gig Harbor | Washington | 98332 | — |
| American Oncology Network Vista Oncology Division-West office | Olympia | Washington | 98502 | — |
| American Oncology Network Vista Oncology Division | Olympia | Washington | 98506 | — |
| Northwest Medical Specialties, PLLC | Puyallup | Washington | 98373 | — |
| Northwest Medical Specialties, PLLC | Tacoma | Washington | 98405 | — |
| Northwest Cancer Specialists, P.C. | Vancouver | Washington | 98684 | — |
| Froedtert Hospital/Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 201 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06012435, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 23, 2026 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06012435 live on ClinicalTrials.gov.