A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Years Old With Severe Asthma

ClinicalTrials.gov ID: NCT06023589

Public ClinicalTrials.gov record NCT06023589. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 3, 2026, 6:02 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Multicentre, Randomised, Double-Blind, Parallel-Group Placebo-Controlled, Phase 3, Efficacy and Safety Study of Tezepelumab in 5 to < 12 Year Old Children With Severe Uncontrolled Asthma (HORIZON)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

To assess the efficacy and safety of tezepelumab in pediatric participants with severe uncontrolled asthma on medium to high-dose inhaled corticosteroids (ICS) and at least one additional asthma controller medication with or without oral corticosteroids.

Study identification

NCT ID: NCT06023589
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: AstraZeneca; Industry
Enrollment: 231 participants

Conditions and interventions

Conditions

Asthma

Interventions

Tezepelumab Biological
Placebo Other

Biological · Other

Eligibility (public fields only)

Age range: 5 Years to 11 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Aug 23, 2023
Primary completion: May 30, 2028
Completion: Aug 22, 2030
Last update posted: Aug 16, 2026

2023 – 2030

United States locations

U.S. sites: 30
U.S. states: 15
U.S. cities: 29

Facility	City	State	ZIP	Site status
Research Site	Montgomery	Alabama	36106	Recruiting
Research Site	Phoenix	Arizona	85016	Recruiting
Research Site	Little Rock	Arkansas	72202	Withdrawn
Research Site	La Jolla	California	92037	Recruiting
Research Site	Long Beach	California	90806	Recruiting
Research Site	Orange	California	92868	Withdrawn
Research Site	San Diego	California	92123	Recruiting
Research Site	Atlanta	Georgia	30322	Recruiting
Research Site	Savannah	Georgia	31406	Terminated
Research Site	Baltimore	Maryland	21287	Recruiting
Research Site	Boston	Massachusetts	02114	Recruiting
Research Site	Boston	Massachusetts	02115	Recruiting
Research Site	Ann Arbor	Michigan	48105	Terminated
Research Site	Detroit	Michigan	48201	Recruiting
Research Site	Northfield	New Jersey	08225	Recruiting
Research Site	Hawthorne	New York	10532	Recruiting
Research Site	Schenectady	New York	12304	Withdrawn
Research Site	Staten Island	New York	10305	Recruiting
Research Site	Chapel Hill	North Carolina	27514	Recruiting
Research Site	Cincinnati	Ohio	45229-3039	Recruiting
Research Site	Cleveland	Ohio	44106	Recruiting
Research Site	Toledo	Ohio	43617	Recruiting
Research Site	Oklahoma City	Oklahoma	73120	Recruiting
Research Site	Columbia	South Carolina	29203	Withdrawn
Research Site	Coppell	Texas	75019	Terminated
Research Site	Dallas	Texas	75246	Recruiting
Research Site	Frisco	Texas	75034	Withdrawn
Research Site	Houston	Texas	77030	Not yet recruiting
Research Site	San Antonio	Texas	78249	Recruiting
Research Site	Temple	Texas	76508	Withdrawn

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 117 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06023589, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Aug 16, 2026 · Synced Sep 3, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06023589 live on ClinicalTrials.gov.

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