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Recruiting Phase 2 Interventional

Reishi Mushroom Extract for Fatigue and/or Arthralgias/Myalgias in Patients With Breast Cancer on Aromatase Inhibitors

ClinicalTrials.gov ID: NCT06028022

Public ClinicalTrials.gov record NCT06028022. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 7, 2026, 11:47 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Reishi Mushroom Extract for Fatigue and/or Arthralgias in Patients With Breast Cancer on Aromatase Inhibitors: A Randomized Phase II MNCCTN Trial

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This phase II trial tests how well Reishi mushroom extract works in treating fatigue and/or joint/muscle pain (arthralgias/myalgias) in patients with breast cancer on aromatase inhibitors. Fatigue and arthralgias/myalgias are common symptoms in breast cancer patients taking aromatase inhibitors (AI). Given the long duration of AI treatment for some women (up to 10 years), these symptoms can significantly impact quality of life and premature discontinuation of AIs, a beneficial medication. Reishi mushrooms are among several medicinal mushrooms that have been used for hundreds of years, mainly in Asian countries, to help enhance the immune system, reduce stress, improve sleep, and lessen fatigue. Reishi mushroom extracts have not been studied explicitly for treatment-induced arthralgias/myalgias, but have been shown to improve quality of life, muscular strength, pain, and flexibility. Information from this study may help researchers determine the effect of Reishi mushroom extract on fatigue and arthralgias/myalgias in breast cancer patients receiving an AI.

Study identification

NCT ID
NCT06028022
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 2
Lead sponsor
Mayo Clinic
Other
Enrollment
80 participants

Conditions and interventions

Interventions

Dietary Supplement · Drug · Other

Eligibility (public fields only)

Age range
18 Years and older
Sex
Female
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Oct 17, 2023
Primary completion
Aug 14, 2027
Completion
Sep 14, 2027
Last update posted
Jun 15, 2026

2023 – 2027

United States locations

U.S. sites
23
U.S. states
1
U.S. cities
22
Facility City State ZIP Site status
Mayo Clinic Health System in Albert Lea Albert Lea Minnesota 56007 Recruiting
Essentia Health Baxter Clinic Baxter Minnesota 56425 Recruiting
Sanford Joe Lueken Cancer Center Bemidji Minnesota 56601 Recruiting
Essentia Health Saint Joseph's Medical Center Brainerd Minnesota 56401 Recruiting
Essentia Health Deer River Clinic Deer River Minnesota 56636 Recruiting
Essentia Health Saint Mary's - Detroit Lakes Clinic Detroit Lakes Minnesota 56501 Recruiting
Essentia Health Cancer Center Duluth Minnesota 55805 Recruiting
Essentia Health Ely Clinic Ely Minnesota 55731 Recruiting
Essentia Health Fosston Fosston Minnesota 56542 Recruiting
Fairview Grand Itasca Clinic & Hospital Grand Rapids Minnesota 55744 Recruiting
Essentia Health Hibbing Clinic Hibbing Minnesota 55746 Recruiting
Fairview Range Medical Center Hibbing Minnesota 55746 Recruiting
Essentia Health International Falls Clinic International Falls Minnesota 56649 Recruiting
Mayo Clinic Health Systems-Mankato Mankato Minnesota 56001 Recruiting
MMCORC CentraCare Monticello Cancer Center Monticello Minnesota 55362 Completed
Essentia Health Moose Lake Moose Lake Minnesota 55767 Recruiting
Essentia Health Park Rapids Park Rapids Minnesota 56470 Recruiting
Fairview Northland Medical Center Princeton Minnesota 55731 Recruiting
Mayo Clinic in Rochester Rochester Minnesota 55905 Recruiting
Essentia Health Sandstone Sandstone Minnesota 55072 Recruiting
Sanford Thief River Falls Medical Center Thief River Falls Minnesota 56701 Recruiting
Essentia Health Virginia Clinic Virginia Minnesota 55792 Recruiting
Sanford Worthington Medical Center Worthington Minnesota 56187 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06028022, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jun 15, 2026 · Synced Sep 7, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06028022 live on ClinicalTrials.gov.

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