Study to Evaluate the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder
Public ClinicalTrials.gov record NCT06029426. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double Blind, Placebo Controlled Study to Evaluate the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a randomized, double blind, placebo controlled, multi-center study to evaluate the effects of NMRA-335140 (formerly BTRX 335140) on symptoms of depression in participants with Major Depressive Disorder (MDD). The study design consists of a Screening Period (up to 28 days), and a 6-week Treatment Period (during which participants will receive either NMRA-335140 or placebo). At the completion of the 6-week Treatment Period, participants who complete the study, provide informed consent, and meet the eligibility criteria may enter an extension study (NMRA-335140 501).
Study identification
- NCT ID
- NCT06029426
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 383 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 20, 2023 (Actual)
- Primary completion
- Dec 3, 2024 (Actual)
- Completion
- Jan 15, 2025 (Actual)
- Last update posted
- Nov 26, 2025
2023 – 2025
United States locations
- U.S. sites
- 64
- U.S. states
- 20
- U.S. cities
- 59
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Neumora Investigator Site | Huntsville | Alabama | 35801 | — |
| Neumora Investigator Site | Phoenix | Arizona | 85012 | — |
| Neumora Investigator Site | Bentonville | Arkansas | 72712 | — |
| Neumora Investigator Site-1 | Little Rock | Arkansas | 72211 | — |
| Neumora Investigator Site | Little Rock | Arkansas | 72211 | — |
| Neumora Investigator Site | Rogers | Arkansas | 72758 | — |
| Neumora Investigator Site | Bellflower | California | 90706 | — |
| Neumora Investigator Site | Garden Grove | California | 92845 | — |
| Neumora Investigator Site | Glendale | California | 91206 | — |
| Neumora Investigator Site | Imperial | California | 92251 | — |
| Neumora Investigator Site | Lafayette | California | 94549 | — |
| Neumora Investigator Site | Long Beach | California | 90807 | — |
| Neumora Investigator Site | Los Angeles | California | 90015 | — |
| Neumora Investigator Site | Oceanside | California | 92056 | — |
| Neumora Investigator Site | Orange | California | 92868 | — |
| Neumora Investigator Site | Riverside | California | 92506 | — |
| Neumora Investigator Site | San Jose | California | 95124 | — |
| Neumora Investigator Site #1 | Sherman Oaks | California | 91403 | — |
| Neumora Investigator Site | Sherman Oaks | California | 91403 | — |
| Neumora Investigator Site | Temecula | California | 92591 | — |
| Neumora Investigator Site | Torrance | California | 90504 | — |
| Neumora Investigator Site | Colorado Springs | Colorado | 80910 | — |
| Neumora Investigator Site | Gainesville | Florida | 32607 | — |
| Neumora Investigator Site | Hallandale | Florida | 33009 | — |
| Neumora Investigator Site | Jacksonville | Florida | 32256 | — |
| Neumora Investigator Site | Lauderhill | Florida | 33319 | — |
| Neumora Investigator Site | Maitland | Florida | 32751 | — |
| Neumora Investigator Site | Miami | Florida | 33122 | — |
| Neumora Investigator Site | Miami | Florida | 33125 | — |
| Neumora Investigator Site | Miami | Florida | 33183 | — |
| Neumora Investigator Site | Miami Lakes | Florida | 33016 | — |
| Neumora Investigator Site | Orlando | Florida | 32801 | — |
| Neumora Investigator Site | Tampa | Florida | 33607 | — |
| Neumora Investigator Site | Marietta | Georgia | 30060 | — |
| Neumora Investigator Site | Chicago | Illinois | 60634 | — |
| Neumora Investigator Site | Evanston | Illinois | 60201 | — |
| Neumora Investigator Site | Warrenville | Illinois | 60555 | — |
| Neumora Investigator Site | Boston | Massachusetts | 02116 | — |
| Neumora Investigator Site | Methuen | Massachusetts | 01844 | — |
| Neumora Investigator Site | Watertown | Massachusetts | 02472 | — |
| Neumora Investigator Site | Bloomfield Hills | Michigan | 48302 | — |
| Neumora Investigator Site | Flowood | Mississippi | 39232 | — |
| Neumora Investigator Site | Saint Charles | Missouri | 63304 | — |
| Neumora Investigator Site | Las Vegas | Nevada | 89102 | — |
| Neumora Investigator Site | Brooklyn | New York | 11224 | — |
| Neumora Investigator Site | Cedarhurst | New York | 11516 | — |
| Neumora Investigator Site | New York | New York | 10036 | — |
| Neumora Investigator Site | Staten Island | New York | 10314 | — |
| Neumora Investigator Site | Cleveland | Ohio | 44106 | — |
| Neumora Investigator Site | Columbus | Ohio | 43210 | — |
| Neumora Investigator Site | Dayton | Ohio | 45417 | — |
| Neumora Investigator Site | Garfield Heights | Ohio | 44125 | — |
| Neumora Investigator Site | Allentown | Pennsylvania | 18104 | — |
| Neumora Investigator Site | Media | Pennsylvania | 19063 | — |
| Neumora Investigator Site | Plymouth Meeting | Pennsylvania | 19462 | — |
| Neumora Investigator Site | Memphis | Tennessee | 38119 | — |
| Neumora Investigator Site | Austin | Texas | 78737 | — |
| Neumora Investigator Site | Dallas | Texas | 75235 | — |
| Neumora Investigator Site | Houston | Texas | 77030 | — |
| Neumora Investigator Site | Houston | Texas | 77090 | — |
| Neumora Investigator Site | Wichita Falls | Texas | 76309 | — |
| Neumora Investigator Site | Charlottesville | Virginia | 22903 | — |
| Neumora Investigator Site | Bellevue | Washington | 98007 | — |
| Neumora Investigator Site | Everett | Washington | 98201 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06029426, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 26, 2025 · Synced Oct 29, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06029426 live on ClinicalTrials.gov.