Study of Tilpisertib Fosmecarbil in Participants With Moderately to Severely Active Ulcerative Colitis

ClinicalTrials.gov ID: NCT06029972

Public ClinicalTrials.gov record NCT06029972. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jun 25, 2026, 11:35 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2, Double-Blinded, Randomized, Placebo-Controlled, Dose-Ranging Study Evaluating the Efficacy and Safety of GS-5290 in Participants With Moderately to Severely Active Ulcerative Colitis

Study identification

NCT ID: NCT06029972
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Gilead Sciences; Industry
Enrollment: 176 participants

Conditions and interventions

Conditions

Ulcerative Colitis

Interventions

Tilpisertib Fosmecarbil Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 75 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 4, 2023
Primary completion: Dec 31, 2026
Completion: Jan 31, 2028
Last update posted: Feb 10, 2026

2023 – 2028

United States locations

U.S. sites: 53
U.S. states: 15
U.S. cities: 47

Facility	City	State	ZIP	Site status
GI Alliance	Sun City	Arizona	85351	Recruiting
GastroSb Weight Loss Clinic	Chula Vista	California	91910	Recruiting
Southern California Research Centers	Coronado	California	92118	Recruiting
VVCRD Research	Garden Grove	California	92845	Recruiting
UC San Diego Health System	La Jolla	California	92037	Recruiting
Gastro Care Institute	Lancaster	California	93534	Recruiting
Om Research LLC	Lancaster	California	93534	Recruiting
United Medical Doctors	Murrieta	California	92563	Withdrawn
University of California, Davis	Sacramento	California	95817	Recruiting
University of California San Francisco	San Francisco	California	94115	Recruiting
Amicis Research Center	Valencia	California	91355	Withdrawn
Luna Research	Coral Gables	Florida	33134	Recruiting
University of Florida	Gainesville	Florida	32610	Recruiting
The Medici Medical Research	Hollywood	Florida	33021	Recruiting
Encore Medical Research, LLC	Hollywood	Florida	33024	Withdrawn
Clinical Research of Osceola	Kissimmee	Florida	34741	Recruiting
Florida Research Institute	Largo	Florida	33771	Recruiting
Wellness Research Center	Miami	Florida	33135	Withdrawn
IMIC Inc	Miami	Florida	33176	Withdrawn
Reserka LLC	Miami	Florida	33176	Withdrawn
GI PROS Research	Naples	Florida	34102	Recruiting
Clinical One Research	Orlando	Florida	32807	Recruiting
Digestive and Liver Center of Florida, LLC	Orlando	Florida	32825	Recruiting
Advanced Medical Research Center	Port Orange	Florida	32127	Recruiting
Gastroenterology Associates of Florida - GI Alliance	Wellington	Florida	33414	Withdrawn
Atlanta Center For Gastroenterology P.C.	Decatur	Georgia	30033	Withdrawn
Corewell Health	Grand Rapids	Michigan	49546	Recruiting
Mayo Clinic	Rochester	Minnesota	55905	Recruiting
Gastroenterology Associates of North Mississippi	Oxford	Mississippi	38655	Recruiting
Digestive Health Specialists	Tupelo	Mississippi	38801	Recruiting
St. Charles Clinical Research	St Louis	Missouri	63141	Recruiting
Ellipsis Research Group	Brooklyn	New York	11215	Active, not recruiting
NYU Langone Long Island Clinical Research Associates	Great Neck	New York	11021	Recruiting
Gastroenterology & Hepatology Specialists Inc	Canton	Ohio	44718	Recruiting
Ohio Gastroenterology & Liver Institute	Cincinnati	Ohio	45249	Withdrawn
The Ohio State University Wexner Medical Centre	Columbus	Ohio	43210	Recruiting
Dayton Gastroenterology, LLC	Dayton	Ohio	45145	Recruiting
Great Lakes Gastroenterology Research, LLC	Mentor	Ohio	44060	Recruiting
Hightower Clinical	Oklahoma City	Oklahoma	73134	Withdrawn
Skyline Gastroenterology of West Tennessee	Jackson	Tennessee	38301	Not yet recruiting
Gastroenterology Research of Hill Country	Boerne	Texas	78006	Recruiting
Gastroenterology Research of America	El Paso	Texas	79936	Withdrawn
DHAT Research Institute	Garland	Texas	75044	Withdrawn
Southwest Clinical Trials	Houston	Texas	77074	Withdrawn
GI Alliance	Lubbock	Texas	79410	Recruiting
GI Associates and Endoscopy Center - GI Alliance	Mansfield	Texas	76063	Recruiting
Clinical Associates in Research Therapeutics of America	San Antonio	Texas	78212	Recruiting
Gastroenterology Research of San Antonio	San Antonio	Texas	78229	Recruiting
Tyler Research Institute, LLC	Tyler	Texas	75701	Recruiting
Gastroenterology Associates of Tidewater	Chesapeake	Virginia	23320	Recruiting
Emeritas Group Research	Lansdowne Town Center	Virginia	20176	Recruiting
Gastroenterology Consultants of Southwest Virginia	Roanoke	Virginia	24014	Recruiting
Swedish Medical Center	Seattle	Washington	98122	Withdrawn

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 76 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06029972, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Feb 10, 2026 · Synced Jun 25, 2026

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The complete protocol, eligibility criteria, and contact information for NCT06029972 live on ClinicalTrials.gov.

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