Study of Tilpisertib Fosmecarbil in Participants With Moderately to Severely Active Ulcerative Colitis
Public ClinicalTrials.gov record NCT06029972. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Double-Blinded, Randomized, Placebo-Controlled, Dose-Ranging Study Evaluating the Efficacy and Safety of GS-5290 in Participants With Moderately to Severely Active Ulcerative Colitis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The goal of this study is to learn if tilpisertib fosmecarbil (formerly known as GS-5290) is effective and safe in treating participants with moderate to severe ulcerative colitis. The study will compare participants in different treatment groups treated with tilpisertib fosmecarbil with participants treated with placebo. The primary objective of this study is to demonstrate the efficacy of tilpisertib fosmecarbil, compared to placebo control, in achieving Clinical Response at Week 12.
Study identification
- NCT ID
- NCT06029972
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 176 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 5, 2023 (Actual)
- Primary completion
- Jan 2027 (Estimated)
- Completion
- Feb 2028 (Estimated)
- Last update posted
- Sep 11, 2026
2023 – 2028
United States locations
- U.S. sites
- 35
- U.S. states
- 12
- U.S. cities
- 32
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| GI Alliance | Sun City | Arizona | 85351 | — |
| GastroSb Weight Loss Clinic | Chula Vista | California | 91910 | — |
| Southern California Research Centers | Coronado | California | 92118 | — |
| VVCRD Research | Garden Grove | California | 92845 | — |
| UC San Diego Health System | La Jolla | California | 92037 | — |
| Gastro Care Institute | Lancaster | California | 93534 | — |
| Om Research LLC | Lancaster | California | 93534 | — |
| University of California, Davis | Sacramento | California | 95817 | — |
| University of California San Francisco | San Francisco | California | 94115 | — |
| Luna Research | Coral Gables | Florida | 33134 | — |
| University of Florida | Gainesville | Florida | 32610 | — |
| The Medici Medical Research | Hollywood | Florida | 33021 | — |
| Clinical Research of Osceola | Kissimmee | Florida | 34741 | — |
| Florida Research Institute | Largo | Florida | 33771 | — |
| GI PROS Research | Naples | Florida | 34102 | — |
| Clinical One Research | Orlando | Florida | 32807 | — |
| Digestive and Liver Center of Florida, LLC | Orlando | Florida | 32825 | — |
| Advanced Medical Research Center | Port Orange | Florida | 32127 | — |
| Corewell Health | Grand Rapids | Michigan | 49546 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Gastroenterology Associates of North Mississippi | Oxford | Mississippi | 38655 | — |
| Digestive Health Specialists | Tupelo | Mississippi | 38801 | — |
| St. Charles Clinical Research | St Louis | Missouri | 63141 | — |
| NYU Langone Long Island Clinical Research Associates | Great Neck | New York | 11021 | — |
| Gastroenterology & Hepatology Specialists Inc | Canton | Ohio | 44718 | — |
| The Ohio State University Wexner Medical Centre | Columbus | Ohio | 43210 | — |
| Skyline Gastroenterology of West Tennessee | Jackson | Tennessee | 38301 | — |
| Gastroenterology Research of Hill Country | Boerne | Texas | 78006 | — |
| GI Alliance | Lubbock | Texas | 79410 | — |
| Clinical Associates in Research Therapeutics of America | San Antonio | Texas | 78212 | — |
| Gastroenterology Research of San Antonio | San Antonio | Texas | 78229 | — |
| Tyler Research Institute, LLC | Tyler | Texas | 75701 | — |
| Gastroenterology Associates of Tidewater | Chesapeake | Virginia | 23320 | — |
| Emeritas Group Research | Lansdowne Town Center | Virginia | 20176 | — |
| Gastroenterology Consultants of Southwest Virginia | Roanoke | Virginia | 24014 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 67 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06029972, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 11, 2026 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06029972 live on ClinicalTrials.gov.