Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations
Public ClinicalTrials.gov record NCT06040086. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Multicentre, Randomised, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Tozorakimab in Participants With Symptomatic Chronic Obstructive Pulmonary Disease (COPD) With a History of COPD Exacerbations (MIRANDA)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this Phase III study is to evaluate the efficacy and safety of tozorakimab administered subcutaneously (SC) in adult participants with symptomatic COPD with a history of ≥ 2 moderate or ≥ 1 severe exacerbations of COPD in the 12 months prior to enrolment. Participants should be receiving optimised treatment with inhaled maintenance therapy (ICS/LABA/LAMA triple therapy, or dual therapy if triple is not considered appropriate) throughout at least the last 3 months prior to enrolment.
Study identification
- NCT ID
- NCT06040086
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,454 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 40 Years to 130 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 22, 2023 (Actual)
- Primary completion
- Mar 6, 2026 (Actual)
- Completion
- May 22, 2026 (Actual)
- Last update posted
- Jul 24, 2026
2023 – 2026
United States locations
- U.S. sites
- 57
- U.S. states
- 26
- U.S. cities
- 54
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Birmingham | Alabama | 35205 | — |
| Research Site | Decatur | Alabama | 35603 | — |
| Research Site | Sheffield | Alabama | 35660 | — |
| Research Site | Phoenix | Arizona | 85027 | — |
| Research Site | Tucson | Arizona | 85704 | — |
| Research Site | Yuma | Arizona | 85365 | — |
| Research Site | Los Angeles | California | 90027 | — |
| Research Site | Newport Beach | California | 92663 | — |
| Research Site | San Francisco | California | 94109 | — |
| Research Site | Westminster | California | 92683 | — |
| Research Site | Aurora | Colorado | 80014 | — |
| Research Site | Boulder | Colorado | 80301 | — |
| Research Site | Washington D.C. | District of Columbia | 20037 | — |
| Research Site | Boynton Beach | Florida | 33435 | — |
| Research Site | Cape Coral | Florida | 33990 | — |
| Research Site | Lakeland | Florida | 33805 | — |
| Research Site | Lakeland | Florida | 33813 | — |
| Research Site | Naples | Florida | 34102 | — |
| Research Site | Ocala | Florida | 34470 | — |
| Research Site | Ormond Beach | Florida | 32174 | — |
| Research Site | Atlanta | Georgia | 30344 | — |
| Research Site | Lithonia | Georgia | 30038 | — |
| Research Site | Champaign | Illinois | 61820 | — |
| Research Site | Chicago | Illinois | 60607 | — |
| Research Site | Chicago | Illinois | 60616 | — |
| Research Site | Andover | Kansas | 67002 | — |
| Research Site | Bowling Green | Kentucky | 42101 | — |
| Research Site | Lexington | Kentucky | 40503 | — |
| Research Site | Towson | Maryland | 21286 | — |
| Research Site | Detroit | Michigan | 48202 | — |
| Research Site | Minneapolis | Minnesota | 55425 | — |
| Research Site | Chesterfield | Missouri | 63005 | — |
| Research Site | Chesterfield | Missouri | 63017 | — |
| Research Site | Hannibal | Missouri | 63401 | — |
| Research Site | Papillion | Nebraska | 68046 | — |
| Research Site | Las Vegas | Nevada | 89102 | — |
| Research Site | Toms River | New Jersey | 08755 | — |
| Research Site | The Bronx | New York | 10451 | — |
| Research Site | Charlotte | North Carolina | 28273 | — |
| Research Site | Greenville | North Carolina | 27834 | — |
| Research Site | Huntersville | North Carolina | 28078 | — |
| Research Site | Winston-Salem | North Carolina | 27103 | — |
| Research Site | Dayton | Ohio | 45439 | — |
| Research Site | Lima | Ohio | 45801 | — |
| Research Site | Grants Pass | Oregon | 97527 | — |
| Research Site | Gaffney | South Carolina | 29340 | — |
| Research Site | Union | South Carolina | 29379 | — |
| Research Site | Chattanooga | Tennessee | 37404 | — |
| Research Site | Elizabethton | Tennessee | 37643 | — |
| Research Site | Jackson | Tennessee | 38305 | — |
| Research Site | Dallas | Texas | 75254 | — |
| Research Site | El Paso | Texas | 79902 | — |
| Research Site | Houston | Texas | 77008 | — |
| Research Site | McKinney | Texas | 75069 | — |
| Research Site | San Antonio | Texas | 78258 | — |
| Research Site | Roy | Utah | 84067 | — |
| Research Site | Kenosha | Wisconsin | 53142 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 311 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06040086, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 24, 2026 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06040086 live on ClinicalTrials.gov.