Study to Assess the Effects of Oral NMRA-335140 in Participants With Major Depressive Disorder
Public ClinicalTrials.gov record NCT06058039. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This randomized, double-blind, placebo-controlled, multicenter study will evaluate the effects of NMRA-335140 (formerly BTRX-335140) on symptoms of depression in participants with Major Depressive Disorder (MDD). The study design consists of a Screening Period (up to 35 days), and a 6-week Treatment Period (during which participants will receive either NMRA-335140 or placebo). At the completion of the 6-week Treatment Period, participants who complete the study, provide informed consent, and meet the eligibility criteria may enter an open-label extension study (NMRA-335140-501).
Study identification
- NCT ID
- NCT06058039
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 422 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 21, 2023 (Actual)
- Primary completion
- May 4, 2026 (Actual)
- Completion
- Jun 11, 2026 (Actual)
- Last update posted
- Jul 6, 2026
2023 – 2026
United States locations
- U.S. sites
- 34
- U.S. states
- 11
- U.S. cities
- 30
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Neumora Investigator Site | Cerritos | California | 90703 | — |
| Neumora Investigator Site | Irvine | California | 92614 | — |
| Neumora Investigator Site | Long Beach | California | 90807 | — |
| Neumora Investigator Site | San Diego | California | 92103 | — |
| Neumora Investigator Site | San Francisco | California | 94107 | — |
| Neumora Investigator Site | New Haven | Connecticut | 06520 | — |
| Neumora Investigator Site | Brandon | Florida | 33511 | — |
| Neumora Investigator Site | Hialeah | Florida | 33012 | — |
| Neumora Investigator Site | Hialeah | Florida | 33016 | — |
| Neumora Investigator Site | Jacksonville | Florida | 32256 | — |
| Neumora Investigator Site | Miami | Florida | 33143 | — |
| Neumora Investigator Site | Miami | Florida | 33165 | — |
| Neumora Investigator site | Miami | Florida | 33174 | — |
| Neumora Investigator Site | Miami Beach | Florida | 33140 | — |
| Neumora Investigator site | Miami Springs | Florida | 33166 | — |
| Neumora Investigator Site | Palm Bay | Florida | 32905 | — |
| Neumora Investigator Site | Pembroke Pines | Florida | 33024 | — |
| Neumora Investigator Site | Pompano Beach | Florida | 33060 | — |
| Neumora Investigator Site | Saint Augustine | Florida | 32086 | — |
| Neumora Investigator Site | Atlanta | Georgia | 30328 | — |
| Neumora Investigator Site | Decatur | Georgia | 30030 | — |
| Neumora Investigator Site | Savannah | Georgia | 31405 | — |
| Neumora Investigator Site | Springfield | Massachusetts | 01103 | — |
| Neumora Investigator Site | St Louis | Missouri | 63141 | — |
| Neumora Investigator Site | Omaha | Nebraska | 68112 | — |
| Neumora Investigator Site | Berlin | New Jersey | 08009 | — |
| Neumora Investigator Site | New York | New York | 10029 | — |
| Neumora Investigator Site | New York | New York | 10036 | — |
| Neumora Investigator Site | Staten Island | New York | 10310 | — |
| Neumora Investigator Site | Charlotte | North Carolina | 28211 | — |
| Neumora Investigator Site | Austin | Texas | 78759 | — |
| Neumora Investigator Site | DeSoto | Texas | 75115 | — |
| Neumora Investigator Site | Fort Worth | Texas | 76104 | — |
| Neumora Investigator Site | Plano | Texas | 75093 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 37 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06058039, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 6, 2026 · Synced Oct 28, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06058039 live on ClinicalTrials.gov.