A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma
Public ClinicalTrials.gov record NCT06064877. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double Blind, Placebo - Controlled, Phase 3 Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV -Negative Head and Neck Squamous Cell Carcinoma. (FIERCE-HN)
Study identification
- NCT ID
- NCT06064877
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- AVEO Pharmaceuticals, Inc.
- Industry
- Enrollment
- 410 participants
Conditions and interventions
Conditions
Interventions
- Ficlatuzumab Biological
- Cetuximab Biological
- Placebo Other
Biological · Other
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 10, 2024
- Primary completion
- Jul 31, 2027
- Completion
- Oct 31, 2027
- Last update posted
- Apr 8, 2026
2024 – 2027
United States locations
- U.S. sites
- 28
- U.S. states
- 20
- U.S. cities
- 26
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85212 | Recruiting |
| The University of Arizona Cancer Center | Tucson | Arizona | 85719 | Recruiting |
| University of California Los Angeles | Los Angeles | California | 90024 | Recruiting |
| Yale School of Medicine - Smilow Cancer Hospital | New Haven | Connecticut | 06511 | Recruiting |
| The George Washington University | Washington D.C. | District of Columbia | 20052-0042 | Recruiting |
| AdventHealth Medical Group Oncology & Hematology at Orlando | Orlando | Florida | 32804 | Recruiting |
| Moffitt Cancer Center | Tampa | Florida | 33612 | Recruiting |
| Emory University | Atlanta | Georgia | 30308 | Recruiting |
| University of Illinois Cancer Center | Chicago | Illinois | 60612 | Recruiting |
| University of Kansas Cancer Center | Westwood | Kansas | 66205 | Recruiting |
| Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | 70809 | Recruiting |
| MaineHealth Institute for Research | South Portland | Maine | 04106 | Recruiting |
| University of Maryland | Baltimore | Maryland | 21201 | Recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Recruiting |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215 | Recruiting |
| Siteman Cancer Center - Washington University | St Louis | Missouri | 63110 | Recruiting |
| Northwell Health Cancer Institute | Lake Success | New York | 10042 | Recruiting |
| Manhattan Eye, Ear & Throat Hospital | New York | New York | 10065 | Recruiting |
| Montefiore Medical Center | The Bronx | New York | 10461 | Withdrawn |
| University of Cincinnati - UC Health Barrett Cancer Center | Cincinnati | Ohio | 45219 | Withdrawn |
| Ohio State University, James Cancer Hospital and Solove Research Institute | Columbus | Ohio | 43210 | Recruiting |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | Recruiting |
| University of Pittsburgh Medical Center - Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | Recruiting |
| Medical University of South Carolina (MUSC) | Charleston | South Carolina | 29425 | Recruiting |
| MD Anderson Cancer Center | Houston | Texas | 77030 | Recruiting |
| Oncology Consultants | Houston | Texas | 77030 | Recruiting |
| VCU Massey Cancer Center | Richmond | Virginia | 23298 | Recruiting |
| Medical College of Wisconsin - Froedtert Hospital Cancer Center | Milwaukee | Wisconsin | 53202 | Terminated |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 84 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06064877, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 8, 2026 · Synced Jul 21, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06064877 live on ClinicalTrials.gov.