A Study to Test Whether Survodutide (BI 456906) Helps People Living With Overweight or Obesity Who Also Have Diabetes to Lose Weight
Public ClinicalTrials.gov record NCT06066528. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomised, Double-blind, Parallel-group, 76-week, Efficacy and Safety Study of BI 456906 Administered Subcutaneously Compared With Placebo in Participants With Overweight or Obesity and Type 2 Diabetes Mellitus
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is open to adults who are at least 18 years old and have a body mass index of 27 kg/m² or more. People can take part if they have type 2 diabetes and if they are currently being treated only with diet and exercise or with specific diabetes medications. Only people who have previously not managed to lose weight by changing their diet can participate. The purpose of this study is to find out whether a medicine called survodutide (BI 456906) helps people living with overweight or obesity who also have diabetes to lose weight. Participants are divided into 3 groups by chance, like drawing names from a hat. 2 groups get different doses of survodutide and 1 group gets placebo. Placebo looks like survodutide but does not contain any medicine. Every participant has a 2 in 3 chance of getting survodutide. Participants inject survodutide or placebo under their skin once a week for about one and a half years. In addition to the study medicine, all participants receive counselling to make changes to their diet and to exercise regularly. Participants are in the study for about 1 year and 7 months. During this time, it is planned that participants visit the study site up to 14 times and receive 6 phone calls by the site staff. The doctors check participants' health and take note of any unwanted effects. The study staff also regularly measure participants' body weight. The results are compared between the groups to see whether the treatment works.
Study identification
- NCT ID
- NCT06066528
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 755 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 26, 2023
- Primary completion
- Dec 11, 2025
- Completion
- Mar 31, 2026
- Last update posted
- Aug 5, 2026
2023 – 2026
United States locations
- U.S. sites
- 34
- U.S. states
- 20
- U.S. cities
- 34
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pinnacle Research Group, LLC | Anniston | Alabama | 36207 | — |
| EmVenio Research-Atlanta-69582 | Phoenix | Arizona | 85032 | — |
| Encompass Clinical Research, Spring Valley | Spring Valley | California | 91978 | — |
| Diablo Clinical Research | Walnut Creek | California | 94598 | — |
| Alliance for Multispecialty Research, LLC - Doral | Doral | Florida | 33172 | — |
| University of Florida | Gainesville | Florida | 32610 | — |
| East Coast Institute for Research, LLC - Jacksonville | Jacksonville | Florida | 32216 | — |
| New Horizon Research Center-Miami-69732 | Miami | Florida | 33165 | — |
| West Orange Endocrinology | Ocoee | Florida | 34761 | — |
| Emory University | Atlanta | Georgia | 30303 | — |
| East-West Medical Research | Honolulu | Hawaii | 96814 | — |
| Solaris Clinical Research | Meridian | Idaho | 83646 | — |
| Evanston Premier Healthcare Research LLC | Skokie | Illinois | 60077 | — |
| Velocity Clinical Research-Valparaiso-68883 | Valparaiso | Indiana | 46383 | — |
| Velocity Clinical Research-Sioux City-69728 | Sioux City | Iowa | 51106 | — |
| AMR Lexington | Lexington | Kentucky | 40509 | — |
| L-MARC Research Center | Louisville | Kentucky | 40213 | — |
| StudyMetrix Research, LLC | City of Saint Peters | Missouri | 63303 | — |
| Walgreens Clinical Trials-Atlantic City-69647 | Atlantic City | New Jersey | 08401 | — |
| Walgreens - Perth Amboy - Site 4544 | Perth Amboy | New Jersey | 08861 | — |
| Premier Research, Inc. | Trenton | New Jersey | 08611 | — |
| Velocity Clinical Research - Binghamton | Binghamton | New York | 13905 | — |
| Southgate Medical Group/ Southgate Medical Park | West Seneca | New York | 14224 | — |
| Physicians East, PA | Greenville | North Carolina | 27834 | — |
| Lucas Research, Inc. | Morehead City | North Carolina | 28557 | — |
| Accellacare-Wilmington-67123 | Wilmington | North Carolina | 28401 | — |
| EmVenio Research-Oklahoma City-70053 | Oklahoma City | Oklahoma | 73139 | — |
| Trial Management Associates | Myrtle Beach | South Carolina | 29572 | — |
| Texas Diabetes and Endocrinology | Austin | Texas | 78731 | — |
| Juno Research, LLC | Houston | Texas | 77040 | — |
| Diabetes & Glandular Disease Clinic, P.A. | San Antonio | Texas | 78229 | — |
| Consano Clinical Research | Shavano Park | Texas | 78231 | — |
| Manassas Clinical Research Center | Manassas | Virginia | 20110 | — |
| Rainier Clinical Research Center | Renton | Washington | 98057 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 109 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06066528, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 5, 2026 · Synced Sep 1, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06066528 live on ClinicalTrials.gov.