A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer
Public ClinicalTrials.gov record NCT06072781. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Open-Label Study of Combination Therapy With Avutometinib Plus Defactinib Versus Investigator's Choice of Treatment in Patients With Recurrent Low-Grade Serous Ovarian Cancer (LGSOC) (RAMP 301)
Study identification
- NCT ID
- NCT06072781
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Verastem, Inc.
- Industry
- Enrollment
- 270 participants
Conditions and interventions
Conditions
Interventions
- Anastrozole Drug
- Defactinib Drug
- Letrozole Drug
- Paclitaxel Drug
- Pegylated liposomal doxorubicin Drug
- avutometinib Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 17, 2024
- Primary completion
- Oct 14, 2028
- Completion
- Feb 8, 2031
- Last update posted
- Apr 1, 2026
2024 – 2031
United States locations
- U.S. sites
- 38
- U.S. states
- 21
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| HonorHealth | Phoenix | Arizona | 85016 | Recruiting |
| University of Arkansas | Little Rock | Arkansas | 72205 | Recruiting |
| UCLA Health | Los Angeles | California | 90095 | Recruiting |
| UC Davis | Sacramento | California | 95817 | Recruiting |
| University of California, San Francisco | San Francisco | California | 94143 | Recruiting |
| Yale University | New Haven | Connecticut | 06520 | Recruiting |
| Florida Cancer Specialists - South | Fort Myers | Florida | 33901 | Recruiting |
| Mount Sinai | Miami Beach | Florida | 33140 | Recruiting |
| AdventHealth | Orlando | Florida | 32804 | Recruiting |
| Moffitt Cancer Center | Tampa | Florida | 33612 | Recruiting |
| Florida Cancer Specialists Research East | West Palm Beach | Florida | 33401 | Recruiting |
| Winship Cancer Institute at Emory University | Atlanta | Georgia | 30322 | Recruiting |
| NorthShore University HealthSystem | Evanston | Illinois | 60201 | Recruiting |
| Louisiana State University | New Orleans | Louisiana | 70112 | Recruiting |
| Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore | Maryland | 21287 | Recruiting |
| Karmanos Cancer Center | Detroit | Michigan | 48201 | Recruiting |
| Minnesota Oncology Hematology | Minneapolis | Minnesota | 55404 | Recruiting |
| Washington University School of Medicine | St Louis | Missouri | 63110 | Recruiting |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | Recruiting |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | Recruiting |
| Atrium Health | Charlotte | North Carolina | 28203 | Recruiting |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | Recruiting |
| Ohio State | Hilliard | Ohio | 43026 | Recruiting |
| University of Oklahoma Medical Center | Oklahoma City | Oklahoma | 73104 | Recruiting |
| Willamette Valley Cancer Institute | Eugene | Oregon | 97401 | Recruiting |
| Northwest Cancer Specialists | Portland | Oregon | 97227 | Recruiting |
| Asplundh Cancer Pavilion | Jefferson Health | Philadelphia | Pennsylvania | 19090 | Recruiting |
| Allegheny Health Network | Pittsburgh | Pennsylvania | 15224 | Recruiting |
| Texas Oncology Central | Austin | Texas | 78731 | Recruiting |
| Texas Oncology-Fort Worth Cancer Center | Fort Worth | Texas | 76104 | Recruiting |
| Houston Methodist | Houston | Texas | 77030 | Recruiting |
| MD Anderson Cancer Center | Houston | Texas | 77030 | Recruiting |
| Texas Oncology | San Antonio | Texas | 78229 | Recruiting |
| Texas Oncology | The Woodlands | Texas | 77380 | Recruiting |
| Texas Oncology | Tyler | Texas | 75702 | Recruiting |
| Intermountain Medical Center | Murray | Utah | 84107 | Recruiting |
| University of Virginia Health System | Charlottesville | Virginia | 22908 | Recruiting |
| Virginia Cancer Specialists, PC | Gainesville | Virginia | 20155 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 68 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06072781, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 1, 2026 · Synced May 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06072781 live on ClinicalTrials.gov.