Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction
Public ClinicalTrials.gov record NCT06077240. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Evaluating The Effects Of E-cigarettes Versus Oral Nicotine Pouches and Product Constituents (Menthol Flavor, Nicotine Concentration) On Adult Cigarette Smoking and Addiction
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The study will recruit an anticipated 256 adults who currently smoke cigarettes and report a willingness to try switching to alternative, non-combustible products. Participants will be randomized to receive either e-cigarettes or nicotine pouches for a duration of 4 weeks and to 1 of 4 possible regulatory scenarios within products where flavor availability is either menthol and tobacco/unflavored available or tobacco/unflavored only available, and nicotine concentration is either higher (5% e-cig, 6mg pouch) or lower (2.4% e-cig, 3mg pouch). Participants will return for bi-weekly research visits (in person or remote videocall) to complete measures for study aims. Participants will complete a final follow-up at Week 6 to assess maintenance of cigarette reduction and willingness to continue using products once they are no longer provided. The investigators expect to observe which products and constituents lead to greater smoking reduction.
Study identification
- NCT ID
- NCT06077240
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 256 participants
Conditions and interventions
Conditions
Interventions
- E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors Behavioral
- E-cigarette with 2.4% Nicotine with Tobacco Flavor Only Behavioral
- E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors Behavioral
- E-cigarette with 5% Nicotine with Tobacco Flavor Only Behavioral
- Tobacco Pouches with 3mg Nicotine with Menthol and Tobacco Flavors Behavioral
- Tobacco Pouches with 3mg Nicotine with Tobacco Flavor Only Behavioral
- Tobacco Pouches with 6mg Nicotine with Menthol and Tobacco Flavors Behavioral
- Tobacco Pouches with 6mg Nicotine with Tobacco Flavor Only Behavioral
Behavioral
Eligibility (public fields only)
- Age range
- 21 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 19, 2024
- Primary completion
- Mar 31, 2028
- Completion
- Mar 31, 2028
- Last update posted
- Mar 18, 2026
2024 – 2028
United States locations
- U.S. sites
- 1
- U.S. states
- 1
- U.S. cities
- 1
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Yale University | New Haven | Connecticut | 06520 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06077240, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 18, 2026 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06077240 live on ClinicalTrials.gov.