ClinicalTrials.gov record
A Study to Test the Effect of Survodutide (BI 456906) on Cardiovascular Safety in People With Overweight or Obesity (SYNCHRONIZE™ - CVOT)
ClinicalTrials.gov ID: NCT06077864
Public ClinicalTrials.gov record NCT06077864. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 6, 2026, 8:10 PM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomised, Double-blind, Parallel-group, Event-driven, Cardiovascular Safety Study With BI 456906 Administered Subcutaneously Compared With Placebo in Participants With Overweight or Obesity With Established Cardiovascular Disease (CVD) or Chronic Kidney Disease, and/or at Least Two Weight-related Complications or Risk Factors for CVD
Study identification
- NCT ID
- NCT06077864
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Boehringer Ingelheim
- Industry
- Enrollment
- 5,530 participants
Conditions and interventions
Conditions
Interventions
- Placebo Combination Product
- survodutide Combination Product
Combination Product
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 19, 2023
- Primary completion
- Apr 30, 2026
- Completion
- Jun 21, 2026
- Last update posted
- Apr 30, 2026
2023 – 2026
United States locations
- U.S. sites
- 153
- U.S. states
- 39
- U.S. cities
- 138
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cardiology P.C. | Birmingham | Alabama | 35211 | — |
| AMR Daphne | Daphne | Alabama | 36526 | — |
| AMR Mobile | Mobile | Alabama | 36608 | — |
| Mobile Heart Specialists, PC | Mobile | Alabama | 36608 | — |
| The Institute for Liver Health II DBA Arizona Clinical Trials | Chandler | Arizona | 85225 | — |
| Clinical Research Institute of Arizona, LLC | Sun City West | Arizona | 85375 | — |
| AMR Phoenix | Tempe | Arizona | 85281 | — |
| Arizona Liver Health-Tucson-67516 | Tucson | Arizona | 85712 | — |
| Yuma Clinical Trials | Yuma | Arizona | 85364 | — |
| Lynn Institute of the Ozarks | Little Rock | Arkansas | 72204 | — |
| Velocity Clinical Research-Huntington Park | Huntington Park | California | 90255 | — |
| Velocity Clinical Research, San Diego | La Mesa | California | 91942 | — |
| Velocity Clinical Research - Los Angeles | Los Angeles | California | 90017 | — |
| Catalina Research Institute, LLC | Montclair | California | 91763 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| NorCal Endocrinology and Internal Medicine | San Ramon | California | 94583 | — |
| Velocity Clinical Research, Santa Ana | Santa Ana | California | 92704 | — |
| NorthBay Clinical Research, LLC | Santa Rosa | California | 95405 | — |
| Velocity Clinical Research-Van Nuys-70286 | Van Nuys | California | 91405 | — |
| Peak Gastroenterology Associates-Colorado Springs-62256 | Colorado Springs | Colorado | 80907 | — |
| Bridgeport Hospital | Bridgeport | Connecticut | 06610 | — |
| CMR of Greater New Haven, LLC | Hamden | Connecticut | 06517 | — |
| Chase Medical Research, LLC | Waterbury | Connecticut | 06708 | — |
| Proactive Clinical Research | Boca Raton | Florida | 33431 | — |
| Excel Medical Clinical Trials | Boca Raton | Florida | 33434 | — |
| Clinical Research of West Florida, Inc. | Clearwater | Florida | 33765 | — |
| Nature Coast Clinical Research-Crystal River-62355 | Crystal River | Florida | 34429 | — |
| Beautiful Minds Clinical Research Center | Cutler Bay | Florida | 33157 | — |
| AMR Fort Myers | Fort Myers | Florida | 33912 | — |
| Covenant Metabolic Specialists, LLC - Fort Myers | Fort Myers | Florida | 33912 | — |
| Velocity Clinical Research-Hallandale Beach-67888 | Hallandale | Florida | 33009 | — |
| Westside Center for Clinical Research | Jacksonville | Florida | 32205 | — |
| Clinical Site Partners LLC | Leesburg | Florida | 34748 | — |
| Flourish Research - Miami | Miami | Florida | 33135 | — |
| Verus Clinical Research Corporation | Miami | Florida | 33135 | — |
| Center for Diabetes, Obesity and Metabolism | Pembroke Pines | Florida | 33024 | — |
| Synexus-Pinellas Park-69294 | Pinellas Park | Florida | 33781 | — |
| East Coast Institute for Research, LLC-Saint Augustine-63032 | Saint Augustine | Florida | 32086 | — |
| Lenus Research & Medical Group | Sweetwater | Florida | 33172 | — |
| Santos Research Center, Corp. | Tampa | Florida | 33615 | — |
| Covenant Metabolic Specialists, LLC - Sarasota | University Park | Florida | 34201 | — |
| Javara-Albany-67356 | Albany | Georgia | 31707 | — |
| Centricity Research Columbus Georgia Multispecialty | Columbus | Georgia | 31904 | — |
| Javara-Fayetteville-67354 | Fayetteville | Georgia | 30214 | — |
| NSC Research Inc | Johns Creek | Georgia | 30024 | — |
| The Jones Center Clinical Research, LLC | Macon | Georgia | 31210 | — |
| Urban Family Practice Associates, PC | Marietta | Georgia | 30067 | — |
| Javara-Savannah-67450 | Savannah | Georgia | 31406 | — |
| Endeavor Health Clinical Operations - Northwest Community Healthcare | Arlington Heights | Illinois | 60005 | — |
| Cedar Crosse Research Center | Chicago | Illinois | 60607 | — |
| Research by Design, LLC | Chicago | Illinois | 60643 | — |
| Medisphere Medical Research Center | Evansville | Indiana | 47714 | — |
| McFarland Clinic PC | Ames | Iowa | 50010 | — |
| Iowa Diabetes and Endocrinology Research Center | West Des Moines | Iowa | 50266 | — |
| AMR El Dorado | El Dorado | Kansas | 67042 | — |
| AMR Newton | Newton | Kansas | 67114 | — |
| AMR Clinical Wichita | Wichita | Kansas | 67226 | — |
| Research Integrity, LLC | Owensboro | Kentucky | 42303 | — |
| Grace Research, LLC-Bossier City-51040 | Bossier City | Louisiana | 71111 | — |
| Heart Clinic of Hammond | Hammond | Louisiana | 70403 | — |
| Tandem Clinical Research | Marrero | Louisiana | 70072 | — |
| AMR New Orleans | New Orleans | Louisiana | 70119 | — |
| Grace Research, LLC-Shreveport-64616 | Shreveport | Louisiana | 71105 | — |
| Javara Inc.-Annapolis-68997 | Annapolis | Maryland | 21401 | — |
| Ascension Saint Agnes Heart Care | Baltimore | Maryland | 21229 | — |
| MD Medical Research | Oxon Hill | Maryland | 20745 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Domino's Farms | Ann Arbor | Michigan | 48105 | — |
| Elite Research Center, LLC | Flint | Michigan | 48532 | — |
| Healthy Heart Cardiology | Grand Rapids | Michigan | 49546 | — |
| Mayo Clinic, Rochester | Rochester | Minnesota | 55905 | — |
| The National Diabetes & Obesity Research Institute | Diamondhead | Mississippi | 39525 | — |
| Prime Health and Wellness | Fayette | Mississippi | 39069 | — |
| Velocity Clinical Research-Gulfport-68930 | Gulfport | Mississippi | 39503 | — |
| Clinical Research Consultants, LLC | Kansas City | Missouri | 64111 | — |
| AMR Kansas City | Kansas City | Missouri | 64114 | — |
| Clinvest Research LLC | Springfield | Missouri | 65807 | — |
| Sundance Clinical Research, LLC | St Louis | Missouri | 63141 | — |
| Mercury Street Medical | Butte | Montana | 59701 | — |
| Skyline Medical Center | Elkhorn | Nebraska | 68022 | — |
| Methodist Physicians Clinic | Fremont | Nebraska | 68025 | — |
| AMR Las Vegas | Las Vegas | Nevada | 89119 | — |
| Advanced Heart Care, LLC | Bridgewater | New Jersey | 08807 | — |
| NJ Heart LLC | Linden | New Jersey | 07036 | — |
| IMA Clinical Research-Warren-69742 | Warren Township | New Jersey | 07059 | — |
| IMA Clinical Research Albuquerque | Albuquerque | New Mexico | 87109 | — |
| Velocity Clinical Research - Binghamton | Binghamton | New York | 13905 | — |
| Synexus Clinical Research US, Inc. | New York | New York | 10017 | — |
| Saratoga Clinical Research, LLC | Saratoga Springs | New York | 12866 | — |
| Accellacare of Cary | Cary | North Carolina | 27518 | — |
| The University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27514 | — |
| Javara-Charlotte-67884 | Charlotte | North Carolina | 28210 | — |
| Accellacare-Mooresville-69123 | Mooresville | North Carolina | 28117 | — |
| Centricity Research (New Bern) | New Bern | North Carolina | 28562 | — |
| Wake Forest University Health Sciences-Winston-Salem-69719 | Winston-Salem | North Carolina | 27104 | — |
| Velocity Clinical Research-Cincinnati-69044 | Cincinnati | Ohio | 45242 | — |
| Synexus Clinical Research-Columbus-69427 | Columbus | Ohio | 43212 | — |
| Centricity Research-Columbus-68879 | Columbus | Ohio | 43213 | — |
| Aventiv Research Inc.-Dublin-62009 | Dublin | Ohio | 43016 | — |
| Clinical Research Institute of Ohio, LLC | Westlake | Ohio | 44145 | — |
| Tekton Research-Edmond-68875 | Edmond | Oklahoma | 73013 | — |
| AMR Norman | Norman | Oklahoma | 73069 | — |
| Lynn Institute of Norman | Norman | Oklahoma | 73072 | — |
| Lynn Health Science Institute | Oklahoma City | Oklahoma | 73112 | — |
| South Oklahoma Heart Research Group | Oklahoma City | Oklahoma | 73135 | — |
| Velocity Clinical Research-Medford-69053 | Medford | Oregon | 97504 | — |
| Heritage Valley Medical Group | Beaver | Pennsylvania | 15009 | — |
| Capital Area Research, LLC | Camp Hill | Pennsylvania | 17011 | — |
| Tristar Clinical Investigations PC | Philadelphia | Pennsylvania | 19114 | — |
| Preferred Primary Care Physicians-Pittsburgh-63932 | Pittsburgh | Pennsylvania | 15236 | — |
| Preferred Primary Care Physicians-Uniontown-69137 | Uniontown | Pennsylvania | 15401 | — |
| Velocity Clinical Research-East Greenwich-68873 | East Greenwich | Rhode Island | 02818 | — |
| Synexus - Anderson | Anderson | South Carolina | 29621 | — |
| Velocity Clinical Research-Anderson-69093 | Anderson | South Carolina | 29621 | — |
| Velocity Clinical Research-Gaffney-69046 | Gaffney | South Carolina | 29340 | — |
| Tribe Clinical Research LLC | Greenville | South Carolina | 29607 | — |
| Velocity Clinical Research-Greenville-69045 | Greenville | South Carolina | 29615 | — |
| Coastal Carolina Research Center | North Charleston | South Carolina | 29405 | — |
| Velocity Clinical Research-Union-68888 | Union | South Carolina | 29379 | — |
| Internal Medicine and Pediatric Associates of Bristol, PC | Bristol | Tennessee | 37620 | — |
| Chattanooga Research & Medicine, PLLC | Chattanooga | Tennessee | 37404 | — |
| Alliance for Multispecialty Research, LLC-Knoxville-69693 | Knoxville | Tennessee | 37909 | — |
| Accellacare of Knoxville-Knoxville-69135 | Knoxville | Tennessee | 37912 | — |
| Accellacare of Knoxville-Knoxville-69714 | Knoxville | Tennessee | 37938 | — |
| Clinical Neuroscience Solutions, Inc-Memphis-65988 | Memphis | Tennessee | 38119 | — |
| Clinical Research Associates, Inc | Nashville | Tennessee | 37203 | — |
| Amarillo Medical Specialists | Amarillo | Texas | 79124 | — |
| Velocity Clinical Research, Austin | Austin | Texas | 78759 | — |
| Headlands Research | Brownsville | Texas | 78526 | — |
| Privia Medical Group Gulf Coast, PLLC | Conroe | Texas | 77384 | — |
| Velocity Clinical Research-Dallas-69170 | Dallas | Texas | 75230 | — |
| Javara Inc. - Fort Worth | Fort Worth | Texas | 76133 | — |
| Houston Research Institute | Houston | Texas | 77079 | — |
| IMA Clinical Research San Antonio | San Antonio | Texas | 78229 | — |
| Tekton Research-San Antonio-68916 | San Antonio | Texas | 78258 | — |
| Javara Inc. and Privia Medical Group Gulf Coast, PLLC | San Marcos | Texas | 78666 | — |
| Javara Inc.-Stephenville-68996 | Stephenville | Texas | 76401 | — |
| DM Clinical Research - Martin Diagnostic Clinic | Tomball | Texas | 77375 | — |
| Velocity Clinical Research, Waco | Waco | Texas | 76710 | — |
| Physicians' Research Options. LLC | Draper | Utah | 84020 | — |
| Alliance for Multispecialty Research, LLC-Layton-69691 | Layton | Utah | 84041 | — |
| Synexus Clinical Research-Salt Lake City-69293 | Salt Lake City | Utah | 84106 | — |
| Chrysalis Clinical Research | St. George | Utah | 84790 | — |
| Velocity Clinical Research-West Jordan-69043 | West Jordan | Utah | 84088 | — |
| Washington Center for Weight Management and Research, Inc. | Arlington | Virginia | 22206 | — |
| Seven Corners Medical Center | Falls Church | Virginia | 22044 | — |
| Eastern Virginia Medical School | Norfolk | Virginia | 23510 | — |
| Selma Medical Associates, Winchester | Winchester | Virginia | 22601 | — |
| Velocity Clinical Research, Seattle | Seattle | Washington | 98105 | — |
| Velocity Clinical Research-Spokane-69716 | Spokane | Washington | 99218 | — |
| Clinical Investigation Specialists, Inc.-Kenosha-69111 | Kenosha | Wisconsin | 53144 | — |
| Allegiance Research Specialists | Wauwatosa | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 387 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06077864, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 30, 2026 · Synced May 6, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06077864 live on ClinicalTrials.gov.