A Study to Test the Effect of Survodutide (BI 456906) on Cardiovascular Safety in People With Overweight or Obesity (SYNCHRONIZE™ - CVOT)
Public ClinicalTrials.gov record NCT06077864. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomised, Double-blind, Parallel-group, Event-driven, Cardiovascular Safety Study With BI 456906 Administered Subcutaneously Compared With Placebo in Participants With Overweight or Obesity With Established Cardiovascular Disease (CVD) or Chronic Kidney Disease, and/or at Least Two Weight-related Complications or Risk Factors for CVD
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is open to adults who are at least 18 years old and have a body mass index (BMI) of 27 kg/m2 or more. People can take part if they have cardiovascular or chronic kidney disease. People who have at least 2 health problems related to their weight or risks of cardiovascular disease can participate. Participants must have previously tried to lose weight by changing their diet. The purpose of this study is to find out whether people with overweight or obesity who take a medicine called survodutide (BI 456906) are less or more likely to develop serious cardiovascular problems. It also aims to find out whether health parameters like blood pressure improve. Overweight and obesity are linked to cardiovascular disease. Survodutide is a medicine that is developed to help people with obesity or overweight to lose weight. Participants are divided into 3 groups of almost equal size. 2 groups get different doses of survodutide and 1 group gets placebo. Placebo looks like survodutide but does not contain any medicine. Every participant has a 2 in 3 chance of getting survodutide. Participants inject survodutide or placebo under the skin once a week. All participants also receive counselling on diet and physical activity. Participants are in the study for up to 2 years and 3 months. During this time, it is planned that participants visit the study site up to 21 times and attend remote visits by video calls. During these visits, the doctors check participants' cardiovascular and overall health. The results are compared between survodutide and placebo groups. The study staff also takes note of any unwanted effects.
Study identification
- NCT ID
- NCT06077864
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 5,531 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 20, 2023 (Actual)
- Primary completion
- Jun 1, 2026 (Actual)
- Completion
- Jun 30, 2026 (Actual)
- Last update posted
- Sep 30, 2026
2023 – 2026
United States locations
- U.S. sites
- 153
- U.S. states
- 39
- U.S. cities
- 138
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cardiology P.C. | Birmingham | Alabama | 35211 | — |
| AMR Daphne | Daphne | Alabama | 36526 | — |
| AMR Mobile | Mobile | Alabama | 36608 | — |
| Mobile Heart Specialists, PC | Mobile | Alabama | 36608 | — |
| The Institute for Liver Health II DBA Arizona Clinical Trials | Chandler | Arizona | 85225 | — |
| Clinical Research Institute of Arizona, LLC | Sun City West | Arizona | 85375 | — |
| AMR Phoenix | Tempe | Arizona | 85281 | — |
| Arizona Liver Health-Tucson-67516 | Tucson | Arizona | 85712 | — |
| Yuma Clinical Trials | Yuma | Arizona | 85364 | — |
| Lynn Institute of the Ozarks | Little Rock | Arkansas | 72204 | — |
| Velocity Clinical Research-Huntington Park | Huntington Park | California | 90255 | — |
| Velocity Clinical Research, San Diego | La Mesa | California | 91942 | — |
| Velocity Clinical Research - Los Angeles | Los Angeles | California | 90017 | — |
| Catalina Research Institute, LLC | Montclair | California | 91763 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| NorCal Endocrinology and Internal Medicine | San Ramon | California | 94583 | — |
| Velocity Clinical Research, Santa Ana | Santa Ana | California | 92704 | — |
| NorthBay Clinical Research, LLC | Santa Rosa | California | 95405 | — |
| Velocity Clinical Research-Van Nuys-70286 | Van Nuys | California | 91405 | — |
| Peak Gastroenterology Associates-Colorado Springs-62256 | Colorado Springs | Colorado | 80907 | — |
| Bridgeport Hospital | Bridgeport | Connecticut | 06610 | — |
| CMR of Greater New Haven, LLC | Hamden | Connecticut | 06517 | — |
| Chase Medical Research, LLC | Waterbury | Connecticut | 06708 | — |
| Proactive Clinical Research | Boca Raton | Florida | 33431 | — |
| Excel Medical Clinical Trials | Boca Raton | Florida | 33434 | — |
| Clinical Research of West Florida, Inc. | Clearwater | Florida | 33765 | — |
| Nature Coast Clinical Research-Crystal River-62355 | Crystal River | Florida | 34429 | — |
| Beautiful Minds Clinical Research Center | Cutler Bay | Florida | 33157 | — |
| AMR Fort Myers | Fort Myers | Florida | 33912 | — |
| Covenant Metabolic Specialists, LLC - Fort Myers | Fort Myers | Florida | 33912 | — |
| Velocity Clinical Research-Hallandale Beach-67888 | Hallandale | Florida | 33009 | — |
| Westside Center for Clinical Research | Jacksonville | Florida | 32205 | — |
| Clinical Site Partners LLC | Leesburg | Florida | 34748 | — |
| Flourish Research - Miami | Miami | Florida | 33135 | — |
| Verus Clinical Research Corporation | Miami | Florida | 33135 | — |
| Center for Diabetes, Obesity and Metabolism | Pembroke Pines | Florida | 33024 | — |
| Synexus-Pinellas Park-69294 | Pinellas Park | Florida | 33781 | — |
| East Coast Institute for Research, LLC-Saint Augustine-63032 | Saint Augustine | Florida | 32086 | — |
| Lenus Research & Medical Group | Sweetwater | Florida | 33172 | — |
| Santos Research Center, Corp. | Tampa | Florida | 33615 | — |
| Covenant Metabolic Specialists, LLC - Sarasota | University Park | Florida | 34201 | — |
| Javara-Albany-67356 | Albany | Georgia | 31707 | — |
| Centricity Research Columbus Georgia Multispecialty | Columbus | Georgia | 31904 | — |
| Javara-Fayetteville-67354 | Fayetteville | Georgia | 30214 | — |
| NSC Research Inc | Johns Creek | Georgia | 30024 | — |
| The Jones Center Clinical Research, LLC | Macon | Georgia | 31210 | — |
| Urban Family Practice Associates, PC | Marietta | Georgia | 30067 | — |
| Javara-Savannah-67450 | Savannah | Georgia | 31406 | — |
| Endeavor Health Clinical Operations - Northwest Community Healthcare | Arlington Heights | Illinois | 60005 | — |
| Cedar Crosse Research Center | Chicago | Illinois | 60607 | — |
| Research by Design, LLC | Chicago | Illinois | 60643 | — |
| Medisphere Medical Research Center | Evansville | Indiana | 47714 | — |
| McFarland Clinic PC | Ames | Iowa | 50010 | — |
| Iowa Diabetes and Endocrinology Research Center | West Des Moines | Iowa | 50266 | — |
| AMR El Dorado | El Dorado | Kansas | 67042 | — |
| AMR Newton | Newton | Kansas | 67114 | — |
| AMR Clinical Wichita | Wichita | Kansas | 67226 | — |
| Research Integrity, LLC | Owensboro | Kentucky | 42303 | — |
| Grace Research, LLC-Bossier City-51040 | Bossier City | Louisiana | 71111 | — |
| Heart Clinic of Hammond | Hammond | Louisiana | 70403 | — |
| Tandem Clinical Research | Marrero | Louisiana | 70072 | — |
| AMR New Orleans | New Orleans | Louisiana | 70119 | — |
| Grace Research, LLC-Shreveport-64616 | Shreveport | Louisiana | 71105 | — |
| Javara Inc.-Annapolis-68997 | Annapolis | Maryland | 21401 | — |
| Ascension Saint Agnes Heart Care | Baltimore | Maryland | 21229 | — |
| MD Medical Research | Oxon Hill | Maryland | 20745 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Domino's Farms | Ann Arbor | Michigan | 48105 | — |
| Elite Research Center, LLC | Flint | Michigan | 48532 | — |
| Healthy Heart Cardiology | Grand Rapids | Michigan | 49546 | — |
| Mayo Clinic, Rochester | Rochester | Minnesota | 55905 | — |
| The National Diabetes & Obesity Research Institute | Diamondhead | Mississippi | 39525 | — |
| Prime Health and Wellness | Fayette | Mississippi | 39069 | — |
| Velocity Clinical Research-Gulfport-68930 | Gulfport | Mississippi | 39503 | — |
| Johnson County ClinTrials | Kansas City | Missouri | 64112 | — |
| AMR Kansas City | Kansas City | Missouri | 64114 | — |
| Clinvest Research LLC | Springfield | Missouri | 65807 | — |
| Sundance Clinical Research, LLC | St Louis | Missouri | 63141 | — |
| Mercury Street Medical | Butte | Montana | 59701 | — |
| Skyline Medical Center | Elkhorn | Nebraska | 68022 | — |
| Methodist Physicians Clinic | Fremont | Nebraska | 68025 | — |
| AMR Las Vegas | Las Vegas | Nevada | 89119 | — |
| Advanced Heart Care, LLC | Bridgewater | New Jersey | 08807 | — |
| NJ Heart LLC | Linden | New Jersey | 07036 | — |
| IMA Clinical Research-Warren-69742 | Warren Township | New Jersey | 07059 | — |
| IMA Clinical Research Albuquerque | Albuquerque | New Mexico | 87109 | — |
| Velocity Clinical Research - Binghamton | Binghamton | New York | 13905 | — |
| Synexus Clinical Research US, Inc. | New York | New York | 10017 | — |
| Saratoga Clinical Research, LLC | Saratoga Springs | New York | 12866 | — |
| Accellacare of Cary | Cary | North Carolina | 27518 | — |
| The University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27514 | — |
| Javara-Charlotte-67884 | Charlotte | North Carolina | 28210 | — |
| Accellacare-Mooresville-69123 | Mooresville | North Carolina | 28117 | — |
| Centricity Research (New Bern) | New Bern | North Carolina | 28562 | — |
| Wake Forest University Health Sciences-Winston-Salem-69719 | Winston-Salem | North Carolina | 27104 | — |
| Velocity Clinical Research-Cincinnati-69044 | Cincinnati | Ohio | 45242 | — |
| Synexus Clinical Research-Columbus-69427 | Columbus | Ohio | 43212 | — |
| Centricity Research-Columbus-68879 | Columbus | Ohio | 43213 | — |
| Aventiv Research Inc.-Dublin-62009 | Dublin | Ohio | 43016 | — |
| Clinical Research Institute of Ohio, LLC | Westlake | Ohio | 44145 | — |
| Tekton Research-Edmond-68875 | Edmond | Oklahoma | 73013 | — |
| AMR Norman | Norman | Oklahoma | 73069 | — |
| Lynn Institute of Norman | Norman | Oklahoma | 73072 | — |
| Lynn Health Science Institute | Oklahoma City | Oklahoma | 73112 | — |
| South Oklahoma Heart Research Group | Oklahoma City | Oklahoma | 73135 | — |
| Velocity Clinical Research-Medford-69053 | Medford | Oregon | 97504 | — |
| Heritage Valley Medical Group | Beaver | Pennsylvania | 15009 | — |
| Capital Area Research, LLC | Camp Hill | Pennsylvania | 17011 | — |
| Tristar Clinical Investigations PC | Philadelphia | Pennsylvania | 19114 | — |
| Preferred Primary Care Physicians-Pittsburgh-63932 | Pittsburgh | Pennsylvania | 15236 | — |
| Preferred Primary Care Physicians-Uniontown-69137 | Uniontown | Pennsylvania | 15401 | — |
| Velocity Clinical Research-East Greenwich-68873 | East Greenwich | Rhode Island | 02818 | — |
| Synexus - Anderson | Anderson | South Carolina | 29621 | — |
| Velocity Clinical Research-Anderson-69093 | Anderson | South Carolina | 29621 | — |
| Velocity Clinical Research-Gaffney-69046 | Gaffney | South Carolina | 29340 | — |
| Tribe Clinical Research LLC - Greenville | Greenville | South Carolina | 29607 | — |
| Velocity Clinical Research-Greenville-69045 | Greenville | South Carolina | 29615 | — |
| Coastal Carolina Research Center | North Charleston | South Carolina | 29405 | — |
| Velocity Clinical Research-Union-68888 | Union | South Carolina | 29379 | — |
| Internal Medicine and Pediatric Associates of Bristol, PC | Bristol | Tennessee | 37620 | — |
| Chattanooga Research & Medicine, PLLC | Chattanooga | Tennessee | 37404 | — |
| Alliance for Multispecialty Research, LLC-Knoxville-69693 | Knoxville | Tennessee | 37909 | — |
| Accellacare of Knoxville-Knoxville-69135 | Knoxville | Tennessee | 37912 | — |
| Accellacare of Knoxville-Knoxville-69714 | Knoxville | Tennessee | 37938 | — |
| Clinical Neuroscience Solutions, Inc-Memphis-65988 | Memphis | Tennessee | 38119 | — |
| Clinical Research Associates, Inc | Nashville | Tennessee | 37203 | — |
| Amarillo Medical Specialists | Amarillo | Texas | 79124 | — |
| Velocity Clinical Research, Austin | Austin | Texas | 78759 | — |
| Headlands Research - Brownsville | Brownsville | Texas | 78526 | — |
| Privia Medical Group Gulf Coast, PLLC | Conroe | Texas | 77384 | — |
| Velocity Clinical Research-Dallas-69170 | Dallas | Texas | 75230 | — |
| Javara Inc. - Fort Worth | Fort Worth | Texas | 76133 | — |
| Houston Research Institute | Houston | Texas | 77079 | — |
| IMA Clinical Research San Antonio | San Antonio | Texas | 78229 | — |
| Tekton Research-San Antonio-68916 | San Antonio | Texas | 78258 | — |
| Javara Inc. and Privia Medical Group Gulf Coast, PLLC | San Marcos | Texas | 78666 | — |
| Javara Inc.-Stephenville-68996 | Stephenville | Texas | 76401 | — |
| DM Clinical Research - Martin Diagnostic Clinic | Tomball | Texas | 77375 | — |
| Velocity Clinical Research, Waco | Waco | Texas | 76710 | — |
| Physicians' Research Options. LLC | Draper | Utah | 84020 | — |
| Alliance for Multispecialty Research, LLC-Layton-69691 | Layton | Utah | 84041 | — |
| Synexus Clinical Research-Salt Lake City-69293 | Salt Lake City | Utah | 84106 | — |
| Chrysalis Clinical Research | St. George | Utah | 84790 | — |
| Velocity Clinical Research-West Jordan-69043 | West Jordan | Utah | 84088 | — |
| Washington Center for Weight Management and Research, Inc. | Arlington | Virginia | 22206 | — |
| Seven Corners Medical Center | Falls Church | Virginia | 22044 | — |
| Eastern Virginia Medical School | Norfolk | Virginia | 23510 | — |
| Selma Medical Associates, Winchester | Winchester | Virginia | 22601 | — |
| Velocity Clinical Research, Seattle | Seattle | Washington | 98105 | — |
| Velocity Clinical Research-Spokane-69716 | Spokane | Washington | 99218 | — |
| Clinical Investigation Specialists, Inc.-Kenosha-69111 | Kenosha | Wisconsin | 53144 | — |
| Allegiance Research Specialists | Wauwatosa | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 387 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06077864, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 30, 2026 · Synced Oct 24, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06077864 live on ClinicalTrials.gov.