National Liver Cancer Screening Trial
Public ClinicalTrials.gov record NCT06084234. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The National Liver Cancer Screening Trial is an adaptive randomized phase IV Trial comparing ultrasound-based versus biomarker-based screening in 5500 patients with cirrhosis from any etiology or patients with chronic hepatitis B infection. Eligible patients will be randomized in a 1:1 fashion to Arm A using semi-annual ultrasound and AFP-based screening or Arm B using semi-annual screening using GALAD alone. Randomization will be stratified by sex, enrolling site, Child Pugh class (A vs. B), and HCC etiology (viral vs. non-viral). Patients will be recruited from 15 sites (mix of tertiary care and large community health systems) over a 3-year period, and the primary endpoint of the phase IV trial, reduction in late-stage HCC, will be assessed after 5.5 years.
Study identification
- NCT ID
- NCT06084234
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 5,500 participants
Conditions and interventions
Interventions
- GALAD Diagnostic Test
- Liver Ultrasound with or without AFP Diagnostic Test
Diagnostic Test
Eligibility (public fields only)
- Age range
- 18 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 25, 2023
- Primary completion
- Dec 30, 2029
- Completion
- Dec 30, 2034
- Last update posted
- Aug 11, 2026
2023 – 2034
United States locations
- U.S. sites
- 19
- U.S. states
- 12
- U.S. cities
- 17
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Southern California | Los Angeles | California | 90089 | Recruiting |
| Stanford University | Redwood City | California | 94063 | Recruiting |
| Kaiser Permanente | Roseville | California | 95661 | Recruiting |
| University of California, San Francisco | San Francisco | California | 94117 | Recruiting |
| Northwestern University | Chicago | Illinois | 60611 | Recruiting |
| Indiana University | Indianapolis | Indiana | 46202 | Recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Recruiting |
| University of Michigan | Ann Arbor | Michigan | 48109 | Recruiting |
| Henry Ford Health System | Detroit | Michigan | 48202 | Recruiting |
| Hennepin Healthcare | Minneapolis | Minnesota | 55415 | Recruiting |
| University of Minnesota | Minneapolis | Minnesota | 55455 | Recruiting |
| The Feinstein Institutes, Northwell Health, Inc. | Manhasset | New York | 11030 | Recruiting |
| University of North Carolina | Chapel Hill | North Carolina | 27599 | Recruiting |
| Case Western Reserve University | Cleveland | Ohio | 44106 | Recruiting |
| The Cleveland Clinic | Cleveland | Ohio | 44195 | Not yet recruiting |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | Recruiting |
| UT Southwestern Medical Center and Parkland Hospital | Dallas | Texas | 75390 | Recruiting |
| Baylor College of Medicine | Houston | Texas | 77021 | Recruiting |
| Virginia Commonwealth University | Richmond | Virginia | 23219 | Not yet recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06084234, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 11, 2026 · Synced Sep 4, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06084234 live on ClinicalTrials.gov.