Study to Investigate Efficacy, Safety, and Tolerability of Zibotentan/Dapagliflozin Compared to Dapagliflozin in Participants With Chronic Kidney Disease and High Proteinuria (ZENITH High Proteinuria)
Public ClinicalTrials.gov record NCT06087835. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Randomised, Multicentre, Double-blind Study to Evaluate the Efficacy, Safety, and Tolerability of Zibotentan/Dapagliflozin Compared to Dapagliflozin Alone in Participants With Chronic Kidney Disease and High Proteinuria
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase III, randomised, multicentre, double-blinded study to evaluate efficacy, safety and tolerability of treatment with zibotentan/dapagliflozin and dapagliflozin alone in participants with chronic kidney disease (CKD) and high proteinuria
Study identification
- NCT ID
- NCT06087835
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,835 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 95 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 7, 2023 (Actual)
- Primary completion
- Feb 18, 2027 (Estimated)
- Completion
- Feb 18, 2027 (Estimated)
- Last update posted
- Oct 13, 2026
2023 – 2027
United States locations
- U.S. sites
- 64
- U.S. states
- 22
- U.S. cities
- 58
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Huntsville | Alabama | 35805 | — |
| Research Site | Sun City West | Arizona | 85375 | — |
| Research Site | Bakersfield | California | 93309 | — |
| Research Site | Huntington Park | California | 90255 | — |
| Research Site | Los Alamitos | California | 90720 | — |
| Research Site | Los Angeles | California | 90010 | — |
| Research Site | Northridge | California | 91324 | — |
| Research Site | Oxnard | California | 93036 | — |
| Research Site | San Carlos | California | 94070 | — |
| Research Site | San Dimas | California | 91773 | — |
| Research Site | Tarzana | California | 91356 | — |
| Research Site | Victorville | California | 92392 | — |
| Research Site | Arvada | Colorado | 80002 | — |
| Research Site | Denver | Colorado | 80230 | — |
| Research Site | Boynton Beach | Florida | 33435 | — |
| Research Site | Hialeah | Florida | 33016 | — |
| Research Site | Hollywood | Florida | 33024 | — |
| Research Site | Jacksonville | Florida | 32204 | — |
| Research Site | Jensen Beach | Florida | 34957 | — |
| Research Site | Miami | Florida | 33126 | — |
| Research Site | Miami | Florida | 33165 | — |
| Research Site | Orlando | Florida | 32806 | — |
| Research Site | Fayetteville | Georgia | 30214 | — |
| Research Site | Champaign | Illinois | 61822 | — |
| Research Site | Chicago | Illinois | 60616 | — |
| Research Site | Hinsdale | Illinois | 60521 | — |
| Research Site | Island Lake | Illinois | 60042 | — |
| Research Site | Skokie | Illinois | 60077 | — |
| Research Site | Bowling Green | Kentucky | 42101 | — |
| Research Site | Shreveport | Louisiana | 71101 | — |
| Research Site | Silver Spring | Maryland | 20901 | — |
| Research Site | Flint | Michigan | 48504 | — |
| Research Site | Flint | Michigan | 48532 | — |
| Research Site | Troy | Michigan | 48098 | — |
| Research Site | City of Saint Peters | Missouri | 63376 | — |
| Research Site | Albany | New York | 12205 | — |
| Research Site | Middletown | New York | 10940 | — |
| Research Site | Orchard Park | New York | 14127 | — |
| Research Site | Greenville | North Carolina | 27834 | — |
| Research Site | Jacksonville | North Carolina | 28546 | — |
| Research Site | Kinston | North Carolina | 28504 | — |
| Research Site | New Bern | North Carolina | 28562 | — |
| Research Site | Statesville | North Carolina | 28625 | — |
| Research Site | Wilmington | North Carolina | 28401 | — |
| Research Site | Wilmington | North Carolina | 28412 | — |
| Research Site | Winston-Salem | North Carolina | 27103 | — |
| Research Site | Maumee | Ohio | 43537 | — |
| Research Site | Pottstown | Pennsylvania | 19464 | — |
| Research Site | East Providence | Rhode Island | 02915 | — |
| Research Site | Kingsport | Tennessee | 37660 | — |
| Research Site | Arlington | Texas | 76015 | — |
| Research Site | Austin | Texas | 78726 | — |
| Research Site | Houston | Texas | 77004 | — |
| Research Site | Houston | Texas | 77099 | — |
| Research Site | Pearland | Texas | 77584 | — |
| Research Site | San Antonio | Texas | 78204 | — |
| Research Site | San Antonio | Texas | 78207 | — |
| Research Site | San Antonio | Texas | 78212 | — |
| Research Site | Sugar Land | Texas | 77478 | — |
| Research Site | South Salt Lake | Utah | 84115 | — |
| Research Site | Alexandria | Virginia | 22311 | — |
| Research Site | Newport News | Virginia | 23606 | — |
| Research Site | Mukilteo | Washington | 98275 | — |
| Research Site | Spokane | Washington | 99204 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 232 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06087835, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 13, 2026 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06087835 live on ClinicalTrials.gov.