A Study to Learn About the Study Medicine Called PF-07220060 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment
Public ClinicalTrials.gov record NCT06105632. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
AN INTERVENTIONAL, OPEN-LABEL, RANDOMIZED, MULTICENTER PHASE 2 STUDY OF PF-07220060 PLUS FULVESTRANT COMPARED TO INVESTIGATOR'S CHOICE OF THERAPY IN PARTICIPANTS AT LEAST 18 YEARS OF AGE WITH HORMONE RECEPTOR-POSITIVE, HER2-NEGATIVE ADVANCED/METASTATIC BREAST CANCER WHOSE DISEASE PROGRESSED AFTER PRIOR CDK 4/6 INHIBITOR-BASED THERAPY (FOURLIGHT-1)
Study identification
- NCT ID
- NCT06105632
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Pfizer
- Industry
- Enrollment
- 333 participants
Conditions and interventions
Conditions
Interventions
- PF-07220060 CDK4 inhibitor Drug
- Fulvestrant Drug
- Everolimus Drug
- Exemestane Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 8, 2024
- Primary completion
- Jan 11, 2026
- Completion
- Jan 20, 2028
- Last update posted
- Feb 12, 2026
2024 – 2028
United States locations
- U.S. sites
- 17
- U.S. states
- 7
- U.S. cities
- 12
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Hoag Health Center Irvine | Irvine | California | 92618 | — |
| Hoag Hospital Irvine | Irvine | California | 92618 | — |
| Keck Hospital of USC | Los Angeles | California | 90033 | — |
| Los Angeles General Medical Center | Los Angeles | California | 90033 | — |
| USC/Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| Hoag Memorial Hospital Presbyterian | Newport Beach | California | 92663 | — |
| Keck Medical Center of USC Pasadena | Pasadena | California | 91105 | — |
| Danbury Hospital | Danbury | Connecticut | 06810 | — |
| Norwalk Hospital | Norwalk | Connecticut | 06856 | — |
| Georgetown University Medical Center | Washington D.C. | District of Columbia | 20007 | — |
| MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| Intermountain Health St. Vincent Regional Hospital | Billings | Montana | 59101 | — |
| Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana | Billings | Montana | 59102 | — |
| Cancer Care Specialists | Reno | Nevada | 89511 | — |
| Vassar Brothers Medical Center | Poughkeepsie | New York | 12601 | — |
| Memorial Hermann Cancer Center | Houston | Texas | 77030 | — |
| Baylor Scott & White Medical Center - Round Rock | Round Rock | Texas | 78665 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 111 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06105632, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 12, 2026 · Synced Jul 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06105632 live on ClinicalTrials.gov.