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Recruiting Phase 3 Interventional

IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301)

ClinicalTrials.gov ID: NCT06112314

Public ClinicalTrials.gov record NCT06112314. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jul 25, 2026, 9:13 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3 Randomized, Controlled Study of IMC-F106C Plus Nivolumab Versus Nivolumab Regimens in HLA-A*02:01-Positive Participants With Previously Untreated Advanced Melanoma (PRISM-MEL-301

Study identification

NCT ID
NCT06112314
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Immunocore Ltd
Industry
Enrollment
680 participants

Conditions and interventions

Interventions

  • Brenetafusp Drug
  • Nivolumab Drug
  • Nivolumab + Relatlimab Drug

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jun 4, 2024
Primary completion
Oct 15, 2027
Completion
Oct 15, 2027
Last update posted
Feb 24, 2026

2024 – 2027

United States locations

U.S. sites
37
U.S. states
23
U.S. cities
33
Facility City State ZIP Site status
University of Arizona Tucson Arizona 85720 Recruiting
University of California - San Diego La Jolla California 92093-0698 Recruiting
The Angeles Clinic and Research Institute- West Los Angeles Los Angeles California 90025 Recruiting
ESC Norris Comprehensive Cancer Center Los Angeles California 90033 Recruiting
UCLA Hematology/Oncology Los Angeles California 90095 Recruiting
Stanford Cancer Institute - Stanford Cancer Center Palo Alto Palo Alto California 94304 Completed
Saint John's Health Center - John Wayne Cancer Institute (JWCI) Santa Monica California 90404 Recruiting
University of Colorado, Anschutz Medical Campus Aurora Colorado 80045 Recruiting
The Melanoma & Skin Cancer Institute Denver Colorado 80222 Recruiting
UConn Health-Farmington (University of Connecticut Health Center (UCHC)) Farmington Connecticut 06030-2205 Completed
Georgetown University Washington D.C. District of Columbia 20007 Recruiting
Mayo Clinic Florida Jacksonville Florida 32224 Recruiting
University of Miami Health System-Sylvester Comprehensive Cancer Center-Miami Miami Florida 33136 Recruiting
Northwestern University - Robert H. Lurie Comprehensive Cancer Center - NMDTI Chicago Illinois 60611 Recruiting
The University of Kansas Cancer Center (KUCC) - Westwood Westwood Kansas 66205 Recruiting
St. Elizabeth Healthcare - Edgewood Edgewood Kentucky 41017 Recruiting
Massachusetts General Hospital Boston Massachusetts 02114 Recruiting
Dana Farber Cancer Institute Boston Massachusetts 02215 Recruiting
Henry Ford Cancer Center - Michigan Detroit Michigan 04820 Recruiting
Allina Health Cancer Institute - Minneapolis Minneapolis Minnesota 55407 Recruiting
Washington University School of Medicine St Louis Missouri 63110 Completed
John Theurer Cancer Center at Hackensack University Medical Center Hackensack New Jersey 07601 Recruiting
Northwell Health Cancer Institute Lake Success New York 11042 Recruiting
Columbia University Medical Center New York New York 10032 Completed
The Ohio State University Columbus Ohio 43210 Recruiting
Thomas Jefferson University Philadelphia Pennsylvania 19107 Recruiting
UPMC Hillman Cancer Center Pittsburgh Pennsylvania 15232 Recruiting
Prisma Health Cancer Institute Greenville South Carolina 29605 Recruiting
Spartanburg Regional Healthcare System - Spartanburg Medical Center (SMC) Spartanburg South Carolina 29303 Recruiting
The University of Tennessee - Knoxville (UTK) Knoxville Tennessee 37920 Recruiting
Sarah Cannon Research Institute: USA/TN Nashville Tennessee 37203 Recruiting
Tennessee Oncology, PLLC Nashville Tennessee 37203 Recruiting
University of Texas Southwestern Dallas Texas 75235-9179 Recruiting
University of Utah Huntsman Cancer Institute Salt Lake City Utah 84112 Recruiting
UVA Health-UVA Emily Couric Clinical Cancer Center Charlottesville Virginia 22903 Recruiting
Virginia Commonwealth University (VCU) - Massey Cancer Center Richmond Virginia 23298-0070 Recruiting
Swedish Medical Center - Swedish Cancer Institute (SCI) - First Hill Campus Seattle Washington 98104 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 174 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06112314, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Feb 24, 2026 · Synced Jul 25, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06112314 live on ClinicalTrials.gov.

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