A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

ClinicalTrials.gov ID: NCT06119581

Public ClinicalTrials.gov record NCT06119581. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Apr 29, 2026, 8:49 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

SUNRAY-01, A Global Pivotal Study in Participants With KRAS G12C-Mutant, Locally Advanced or Metastatic Non-Small Cell Lung Cancer Comparing First-Line Treatment of LY3537982 and Pembrolizumab vs Placebo and Pembrolizumab in Those With PD-L1 Expression ≥50% or LY3537982 and Pembrolizumab, Pemetrexed, Platinum vs Placebo and Pembrolizumab, Pemetrexed, Platinum Regardless of PD-L1 Expression

Study identification

NCT ID: NCT06119581
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Eli Lilly and Company; Industry
Enrollment: 1,264 participants

Conditions and interventions

Conditions

Interventions

Carboplatin Drug
Cisplatin Drug
LY3537982 Drug
Pembrolizumab Drug
Pemetrexed Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 20, 2023
Primary completion: Oct 31, 2027
Completion: Dec 31, 2030
Last update posted: Apr 19, 2026

2023 – 2031

United States locations

U.S. sites: 90
U.S. states: 37
U.S. cities: 78

Facility	City	State	ZIP	Site status
Clearview Cancer Institute	Huntsville	Alabama	35805	Recruiting
Banner MD Anderson Cancer Center	Gilbert	Arizona	85234	Recruiting
Banner University Medical Center Phoenix	Phoenix	Arizona	85006	Recruiting
The University of Arizona Cancer Center - North Campus	Tucson	Arizona	85719	Recruiting
Highlands Oncology Group	Springdale	Arkansas	72762	Recruiting
Cedars-Sinai Medical Center	Los Angeles	California	90048	Recruiting
Mercy Cancer Center	Merced	California	95340	Recruiting
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center	Torrance	California	90502	Completed
BASS Cancer Center	Walnut Creek	California	94598	Recruiting
USO - Rocky Mountain Cancer Centers	Lone Tree	Colorado	80124	Recruiting
Yale University School of Medicine	New Haven	Connecticut	06510	Recruiting
Sibley Memorial Hospital	Washington D.C.	District of Columbia	20016	Recruiting
Millennium Oncology Research Clinic	Hollywood	Florida	33024	Recruiting
University of Florida - Jacksonville	Jacksonville	Florida	32209	Recruiting
Miami Cancer Institute at Baptist Health, Inc.	Miami	Florida	33176	Recruiting
Ocala Oncology Center PL DBA Florida Cancer Affiliates - Ocala	Ocala	Florida	34474	Recruiting
Comprehensive Hematology Oncology	St. Petersburg	Florida	33709	Recruiting
University Cancer & Blood Center, LLC	Athens	Georgia	30607	Recruiting
Emory University School of Medicine- Grady Campus	Atlanta	Georgia	30303	Recruiting
Winship Cancer Institute, Emory University	Atlanta	Georgia	30322	Recruiting
University of Illinois at Chicago	Chicago	Illinois	60612	Recruiting
University of Chicago Hospital	Chicago	Illinois	60637	Recruiting
Springfield Clinic Main Campus	Springfield	Illinois	62702	Recruiting
Parkview Research Center at Parkview Regional Medical Center	Fort Wayne	Indiana	46845	Recruiting
Indiana University Melvin and Bren Simon Cancer Center	Indianapolis	Indiana	46202	Recruiting
Franciscan Health	Indianapolis	Indiana	46237	Recruiting
Community Cancer Center North	Indianapolis	Indiana	46250	Recruiting
The University of Kansas Cancer Center - Westwood	Westwood	Kansas	66205	Recruiting
CHI Saint Joseph Cancer Center - East	Lexington	Kentucky	40509	Recruiting
University of Kentucky Chandler Medical Center	Lexington	Kentucky	40536	Recruiting
Mary Bird Perkins Cancer Center	Baton Rouge	Louisiana	70809	Recruiting
Johns Hopkins Bayview Medical Center	Baltimore	Maryland	21224	Recruiting
USO - Maryland Oncology Hematology	Columbia	Maryland	21044	Recruiting
Boston Medical Center	Boston	Massachusetts	02118	Recruiting
Lahey Hospital & Medical Center	Burlington	Massachusetts	01805	Recruiting
University of Michigan	Ann Arbor	Michigan	48109	Recruiting
Karmanos Cancer Institute	Detroit	Michigan	48201	Recruiting
The Cancer & Hematology Centers	Grand Rapids	Michigan	49503	Recruiting
Allina Health Cancer Institute - Abbott Northwestern Hospital	Minneapolis	Minnesota	55407	Recruiting
HealthPartners Cancer Research Center	Saint Paul	Minnesota	55101	Recruiting
North Mississippi Hematology and Oncology Associates	Tupelo	Mississippi	38801	Recruiting
Oncology Hematology Associates	Springfield	Missouri	65807	Recruiting
Comprehensive Cancer Centers of Nevada	Las Vegas	Nevada	89169	Recruiting
Dartmouth-Hitchcock Medical Center	Lebanon	New Hampshire	03756	Recruiting
The Valley Hospital, Inc.	Paramus	New Jersey	07652	Recruiting
University of New Mexico Comprehensive Cancer Center	Albuquerque	New Mexico	87131	Recruiting
Maimonides Cancer Center	Brooklyn	New York	11220	Recruiting
Northwell Health/ RJ Zuckerberg Cancer Center	Lake Success	New York	11042	Recruiting
Perlmutter Cancer Center at NYU Langone Hospital - Long Island	Mineola	New York	11501	Recruiting
Laura and Isaac Perlmutter Cancer Center	New York	New York	10016	Recruiting
Manhattan Eye, Ear and Throat Hospital	New York	New York	10065	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
University of North Carolina Medical Center	Chapel Hill	North Carolina	27599	Recruiting
Duke Cancer Institute	Durham	North Carolina	27710	Recruiting
UNC REX Cancer Center	Raleigh	North Carolina	27607	Recruiting
USO - Oncology Hematology Care	Cincinnati	Ohio	45242	Recruiting
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer -T	Columbus	Ohio	43210	Recruiting
USO - Oncology Associates of Oregon	Eugene	Oregon	97401	Recruiting
Asante Rogue Regional Medical Center	Medford	Oregon	97504	Recruiting
Providence Portland Medical Center	Portland	Oregon	97213	Recruiting
Providence St. Vincent Medical Center	Portland	Oregon	97225	Recruiting
Kaiser Permanente Interstate Medical Office Central	Portland	Oregon	97227	Recruiting
USO - Alliance Cancer Specialists, PC	Horsham	Pennsylvania	19044	Recruiting
Thomas Jefferson University, Sidney Kimmel Cancer Center - Clinical Trials Office	Philadelphia	Pennsylvania	19107	Recruiting
UPMC Hillman Cancer Center	Pittsburgh	Pennsylvania	15232	Recruiting
Lifespan Cancer Institute	Providence	Rhode Island	02903	Recruiting
Medical University of South Carolina	Charleston	South Carolina	29425	Recruiting
Prisma Health Cancer Institute	Greenville	South Carolina	29605	Recruiting
Lexington Medical Center	West Columbia	South Carolina	29169	Recruiting
Tennessee Oncology Chattanooga	Chattanooga	Tennessee	37404	Recruiting
University of Tennessee Medical Center	Knoxville	Tennessee	37920	Recruiting
Baptist Memorial Hospital-Memphis	Memphis	Tennessee	38120	Recruiting
Tennessee Oncology	Nashville	Tennessee	37203	Recruiting
USO - US Oncology Research Network	Nashville	Tennessee	37203	Recruiting
USO - Texas Oncology	Austin	Texas	78745	Recruiting
William Beaumont Army Medical Center	Fort Bliss	Texas	79918	Recruiting
Brooke Army Medical Center	Fort Sam Houston	Texas	78234	Recruiting
Houston Methodist Hospital	Houston	Texas	77030	Recruiting
University of Texas MD Anderson Cancer Center	Houston	Texas	77030	Recruiting
USO - Texas Oncology	Webster	Texas	77598	Recruiting
The University of Vermont Medical Center Inc.	Burlington	Vermont	05401	Recruiting
University of Virginia Health System	Charlottesville	Virginia	22903	Recruiting
USO - Virginia Cancer Specialists	Fairfax	Virginia	22031	Recruiting
VCU Health Adult Outpatient Pavillion	Richmond	Virginia	23219	Recruiting
Swedish Cancer Institute - Edmonds	Edmonds	Washington	98026	Recruiting
Kadlec Clinic Hematology and Oncology	Kennewick	Washington	99336	Recruiting
Swedish Medical Center	Seattle	Washington	98104	Recruiting
VA Puget Sound Health Care System	Seattle	Washington	98108	Recruiting
USO - Northwest Cancer Specialists	Vancouver	Washington	98684	Recruiting
SSM Health Dean Medical Group - South Madison Campus Health Research/Circuit Clinical	Madison	Wisconsin	53715	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 331 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06119581, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 19, 2026 · Synced Apr 29, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06119581 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →