Saruparib (AZD5305) vs Placebo in Men With Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents
Public ClinicalTrials.gov record NCT06120491. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, 2-cohort, Double-blind, Placebo-controlled, Phase III Study of Saruparib (AZD5305) in Combination With Physician's Choice New Hormonal Agents in Patients With HRRm and Non-HRRm Metastatic Castration-Sensitive Prostate Cancer (EvoPAR-Prostate01)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The intention of the study is to demonstrate superiority of Saruparib (AZD5305) + physician's choice NHA relative to placebo + physician's choice NHA by assessment of radiographic progression-free survival (rPFS) in participants with mCSPC.
Study identification
- NCT ID
- NCT06120491
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,898 participants
Conditions and interventions
Interventions
- Saruparib Drug
- Placebo Drug
- Abiraterone Acetate Drug
- Darolutamide Drug
- Enzalutamide Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 130 Years
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 21, 2023 (Actual)
- Primary completion
- Sep 30, 2027 (Estimated)
- Completion
- Apr 30, 2031 (Estimated)
- Last update posted
- Jul 29, 2026
2023 – 2031
United States locations
- U.S. sites
- 71
- U.S. states
- 31
- U.S. cities
- 66
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Chandler | Arizona | 85224 | — |
| Research Site | Gilbert | Arizona | 85234 | — |
| Research Site | Phoenix | Arizona | 85054 | — |
| Research Site | Tucson | Arizona | 85715 | — |
| Research Site | Little Rock | Arkansas | 72205 | — |
| Research Site | Springdale | Arkansas | 72762 | — |
| Research Site | Bakersfield | California | 93301 | — |
| Research Site | Fountain Valley | California | 92708 | — |
| Research Site | Fullerton | California | 92835 | — |
| Research Site | Los Angeles | California | 90073 | — |
| Research Site | Montebello | California | 90640 | — |
| Research Site | San Francisco | California | 94115 | — |
| Research Site | Santa Barbara | California | 93105 | — |
| Research Site | Santa Monica | California | 90404 | — |
| Research Site | Santa Rosa | California | 95403 | — |
| Research Site | Golden | Colorado | 80401 | — |
| Research Site | Lakewood | Colorado | 80228 | — |
| Research Site | New Haven | Connecticut | 06510 | — |
| Research Site | Atlanta | Georgia | 30318 | — |
| Research Site | Glenview | Illinois | 60026 | — |
| Research Site | Lake Barrington | Illinois | 60010 | — |
| Research Site | Fort Wayne | Indiana | 46804 | — |
| Research Site | Indianapolis | Indiana | 46202 | — |
| Research Site | Westwood | Kansas | 66205 | — |
| Research Site | Shreveport | Louisiana | 71103 | — |
| Research Site | Scarborough | Maine | 04074 | — |
| Research Site | Baltimore | Maryland | 21201 | — |
| Research Site | Baltimore | Maryland | 21287 | — |
| Research Site | Bethesda | Maryland | 20817 | — |
| Research Site | Towson | Maryland | 21204 | — |
| Research Site | Upper Marlboro | Maryland | 20774 | — |
| Research Site | Grand Rapids | Michigan | 49503 | — |
| Research Site | Troy | Michigan | 48084 | — |
| Research Site | Rochester | Minnesota | 55905 | — |
| Research Site | Bozeman | Montana | 59715 | — |
| Research Site | Las Vegas | Nevada | 89102 | — |
| Research Site | Las Vegas | Nevada | 89148 | — |
| Research Site | Camden | New Jersey | 08103 | — |
| Research Site | Albuquerque | New Mexico | 87109 | — |
| Research Site | East Syracuse | New York | 13057 | — |
| Research Site | New Hyde Park | New York | 11042 | — |
| Research Site | New York | New York | 10029 | — |
| Research Site | Syracuse | New York | 13210 | — |
| Research Site | Durham | North Carolina | 27710 | — |
| Research Site | Cincinnati | Ohio | 45212 | — |
| Research Site | Cincinnati | Ohio | 45219 | — |
| Research Site | Cleveland | Ohio | 44111 | — |
| Research Site | Cleveland | Ohio | 44124 | — |
| Research Site | Columbus | Ohio | 43210 | — |
| Research Site | Portland | Oregon | 97227 | — |
| Research Site | Bala-Cynwyd | Pennsylvania | 19004-1017 | — |
| Research Site | Philadelphia | Pennsylvania | 19104 | — |
| Research Site | Pittsburgh | Pennsylvania | 15212 | — |
| Research Site | Providence | Rhode Island | 02903 | — |
| Research Site | Myrtle Beach | South Carolina | 29572 | — |
| Research Site | North Charleston | South Carolina | 29406 | — |
| Research Site | Sioux Falls | South Dakota | 57105 | — |
| Research Site | Germantown | Tennessee | 38138 | — |
| Research Site | Nashville | Tennessee | 37203 | — |
| Research Site | Dallas | Texas | 75231 | — |
| Research Site | Houston | Texas | 77025 | — |
| Research Site | San Antonio | Texas | 78229 | — |
| Research Site | Sugar Land | Texas | 77479 | — |
| Research Site | Tyler | Texas | 75702 | — |
| Research Site | Wichita Falls | Texas | 76310 | — |
| Research Site | Salt Lake City | Utah | 84106 | — |
| Research Site | Salt Lake City | Utah | 84132 | — |
| Research Site | St. George | Utah | 84790 | — |
| Research Site | Fairfax | Virginia | 22031 | — |
| Research Site | Spokane | Washington | 99202 | — |
| Research Site | Tacoma | Washington | 98405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 251 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06120491, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 29, 2026 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06120491 live on ClinicalTrials.gov.