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Recruiting Phase 3 Interventional

Saruparib (AZD5305) vs Placebo in Men With Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents

ClinicalTrials.gov ID: NCT06120491

Public ClinicalTrials.gov record NCT06120491. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 7, 2026, 9:03 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, 2-cohort, Double-blind, Placebo-controlled, Phase III Study of Saruparib (AZD5305) in Combination With Physician's Choice New Hormonal Agents in Patients With HRRm and Non-HRRm Metastatic Castration-Sensitive Prostate Cancer (EvoPAR-Prostate01)

Study identification

NCT ID
NCT06120491
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
AstraZeneca
Industry
Enrollment
1,800 participants

Conditions and interventions

Interventions

  • Abiraterone Acetate Drug
  • Darolutamide Drug
  • Enzalutamide Drug
  • Placebo Drug
  • Saruparib Drug

Drug

Eligibility (public fields only)

Age range
18 Years to 130 Years
Sex
Male
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Nov 20, 2023
Primary completion
Jan 10, 2028
Completion
Apr 29, 2031
Last update posted
Apr 2, 2026

2023 – 2031

United States locations

U.S. sites
118
U.S. states
36
U.S. cities
101
Facility City State ZIP Site status
Research Site Chandler Arizona 85224 Active, not recruiting
Research Site Gilbert Arizona 85234 Completed
Research Site Phoenix Arizona 85054 Active, not recruiting
Research Site Tucson Arizona 85741 Active, not recruiting
Research Site Little Rock Arkansas 72205 Active, not recruiting
Research Site Springdale Arkansas 72762 Active, not recruiting
Research Site Bakersfield California 93301 Completed
Research Site Fountain Valley California 92708 Active, not recruiting
Research Site Fullerton California 92835 Active, not recruiting
Research Site Los Angeles California 90073 Active, not recruiting
Research Site Los Angeles California 90095 Withdrawn
Research Site Montebello California 90640 Completed
Research Site Pasadena California 91101 Withdrawn
Research Site Pomona California 91767 Withdrawn
Research Site Sacramento California 95816 Withdrawn
Research Site San Diego California 92123 Withdrawn
Research Site San Francisco California 94115 Active, not recruiting
Research Site Santa Barbara California 93105 Active, not recruiting
Research Site Santa Monica California 90404 Active, not recruiting
Research Site Santa Rosa California 95403 Active, not recruiting
Research Site Golden Colorado 80401 Active, not recruiting
Research Site Lakewood Colorado 80228 Active, not recruiting
Research Site New Haven Connecticut 06510 Recruiting
Research Site Norwich Connecticut 06360 Withdrawn
Research Site Newark Delaware 19713 Withdrawn
Research Site Jacksonville Florida 32209 Withdrawn
Research Site Jacksonville Florida 32224 Withdrawn
Research Site Palm Bay Florida 32909 Withdrawn
Research Site St. Petersburg Florida 33705 Withdrawn
Research Site Tampa Florida 33612 Withdrawn
Research Site Atlanta Georgia 30318 Active, not recruiting
Research Site Glenview Illinois 60026 Active, not recruiting
Research Site Lake Barrington Illinois 60010 Active, not recruiting
Research Site Fort Wayne Indiana 46804 Active, not recruiting
Research Site Indianapolis Indiana 46202 Terminated
Research Site Des Moines Iowa 50309 Withdrawn
Research Site Westwood Kansas 66205 Active, not recruiting
Research Site Wichita Kansas 67226 Withdrawn
Research Site Lexington Kentucky 40503 Withdrawn
Research Site Louisville Kentucky 40202 Withdrawn
Research Site Shreveport Louisiana 71103 Active, not recruiting
Research Site Scarborough Maine 04074 Active, not recruiting
Research Site Baltimore Maryland 21201 Active, not recruiting
Research Site Baltimore Maryland 21287 Active, not recruiting
Research Site Bethesda Maryland 20817 Active, not recruiting
Research Site Towson Maryland 21204 Active, not recruiting
Research Site Upper Marlboro Maryland 20774 Active, not recruiting
Research Site Grand Rapids Michigan 49503 Active, not recruiting
Research Site Troy Michigan 48084 Active, not recruiting
Research Site Rochester Minnesota 55905 Active, not recruiting
Research Site Columbia Missouri 65212 Withdrawn
Research Site Billings Montana 59102 Withdrawn
Research Site Bozeman Montana 59715 Active, not recruiting
Research Site Las Vegas Nevada 89102 Terminated
Research Site Las Vegas Nevada 89148 Active, not recruiting
Research Site Belleville New Jersey 07109 Withdrawn
Research Site Brick New Jersey 08724 Withdrawn
Research Site Camden New Jersey 08103 Active, not recruiting
Research Site East Brunswick New Jersey 08816 Withdrawn
Research Site Voorhees Township New Jersey 08043 Withdrawn
Research Site Albuquerque New Mexico 87109 Active, not recruiting
Research Site Albuquerque New Mexico 87110 Withdrawn
Research Site Rio Rancho New Mexico 87124 Withdrawn
Research Site Albany New York 12206 Withdrawn
Research Site East Syracuse New York 13057 Active, not recruiting
Research Site New Hyde Park New York 11042 Active, not recruiting
Research Site New York New York 10028 Withdrawn
Research Site New York New York 10029 Active, not recruiting
Research Site Shirley New York 11967 Withdrawn
Research Site Syracuse New York 13210 Active, not recruiting
Research Site The Bronx New York 10469 Withdrawn
Research Site Durham North Carolina 27710 Recruiting
Research Site Fayetteville North Carolina 28303 Withdrawn
Research Site Cincinnati Ohio 45212 Active, not recruiting
Research Site Cincinnati Ohio 45219 Active, not recruiting
Research Site Cleveland Ohio 44109 Withdrawn
Research Site Cleveland Ohio 44111 Active, not recruiting
Research Site Cleveland Ohio 44124 Active, not recruiting
Research Site Cleveland Ohio 44130 Withdrawn
Research Site Columbus Ohio 43210 Active, not recruiting
Research Site Independence Ohio 44131 Withdrawn
Research Site Wooster Ohio 44691 Withdrawn
Research Site Florence Oregon 97439 Withdrawn
Research Site Portland Oregon 97227 Active, not recruiting
Research Site Portland Oregon 97239 Withdrawn
Research Site Bala-Cynwyd Pennsylvania 19004-1017 Active, not recruiting
Research Site Philadelphia Pennsylvania 19104 Active, not recruiting
Research Site Pittsburgh Pennsylvania 15212 Active, not recruiting
Research Site Pittsburgh Pennsylvania 15213 Withdrawn
Research Site York Pennsylvania 17403 Withdrawn
Research Site Providence Rhode Island 02903 Recruiting
Research Site Myrtle Beach South Carolina 29572 Recruiting
Research Site North Charleston South Carolina 29406 Active, not recruiting
Research Site Sioux Falls South Dakota 57105 Active, not recruiting
Research Site Germantown Tennessee 38138 Active, not recruiting
Research Site Nashville Tennessee 37203 Active, not recruiting
Research Site Dallas Texas 75231 Active, not recruiting
Research Site Dallas Texas 75246 Withdrawn
Research Site Denton Texas 76201 Withdrawn
Research Site Flower Mound Texas 75028 Withdrawn
Research Site Grapevine Texas 76051 Withdrawn
Research Site Houston Texas 77025 Active, not recruiting
Research Site Houston Texas 77027 Withdrawn
Research Site Houston Texas 77030 Withdrawn
Research Site Plano Texas 75093 Withdrawn
Research Site San Antonio Texas 78217 Withdrawn
Research Site San Antonio Texas 78229 Recruiting
Research Site Sugar Land Texas 77479 Active, not recruiting
Research Site Tyler Texas 75702 Active, not recruiting
Research Site Wichita Falls Texas 76310 Active, not recruiting
Research Site Salt Lake City Utah 84106 Active, not recruiting
Research Site Salt Lake City Utah 84132 Recruiting
Research Site St. George Utah 84790 Active, not recruiting
Research Site Fairfax Virginia 22031 Active, not recruiting
Research Site Winchester Virginia 22601 Withdrawn
Research Site Spokane Washington 99202 Active, not recruiting
Research Site Spokane Valley Washington 99216 Withdrawn
Research Site Tacoma Washington 98405 Active, not recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 291 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06120491, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Apr 2, 2026 · Synced May 7, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06120491 live on ClinicalTrials.gov.

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