AMX0035 and Progressive Supranuclear Palsy
Public ClinicalTrials.gov record NCT06122662. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2b/3 Study of the Safety and Efficacy of AMX0035 in Progressive Supranuclear Palsy (ORION)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
A35-009 (ORION) is a Phase 2b/3 trial to evaluate the efficacy and safety of AMX0035 in participants with Progressive Supranuclear Palsy (PSP), consisting of randomized, double blind placebo controlled phases, followed by an optional open-label extension phase.
Study identification
- NCT ID
- NCT06122662
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 139 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 40 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 21, 2023 (Actual)
- Primary completion
- Sep 30, 2025 (Actual)
- Completion
- Oct 21, 2025 (Actual)
- Last update posted
- Apr 30, 2026
2023 – 2025
United States locations
- U.S. sites
- 35
- U.S. states
- 24
- U.S. cities
- 34
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic | Scottsdale | Arizona | 85259 | — |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| Parkinson's & Movement Disorder Institute | Fountain Valley | California | 92708 | — |
| University of Southern California | Los Angeles | California | 90033 | — |
| Cedars Sinai Medical Center | Los Angeles | California | 90048 | — |
| Stanford Movement Disorder Center | Palo Alto | California | 94304 | — |
| University of California, San Francisco (UCSF) | San Francisco | California | 94158 | — |
| UC Health Anschutz Outpatient Pavilion Anschutz Medical Campus | Aurora | Colorado | 80045 | — |
| Parkinson's Disease and Movement Disorders Center of Boca Raton | Boca Raton | Florida | 33486 | — |
| UF Health Dorothy Mangurian Neuroimaging Suite | Gainesville | Florida | 32608 | — |
| Mayo Clinic Florida | Jacksonville | Florida | 32224 | — |
| Augusta University | Augusta | Georgia | 30912 | — |
| Parkinsons and Movement Disorder Center at the Queens Medical Center | Honolulu | Hawaii | 96813 | — |
| Northwestern University PD and Movement Disorders Center | Chicago | Illinois | 60611 | — |
| University of Kansas Medical Center Research Institute, Inc. | Kansas City | Kansas | 66160 | — |
| University of Kentucky Medical Center | Lexington | Kentucky | 40536-0274 | — |
| Ochsner Medical Center | New Orleans | Louisiana | 70121 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Lahey Hospital and Medical Center | Burlington | Massachusetts | 01805 | — |
| Quest Research Institute | Farmington Hills | Michigan | 48334 | — |
| University of Minnesota, CTSI | Minneapolis | Minnesota | 55414 | — |
| Mayo Clinic - Rochester | Rochester | Missouri | 55905 | — |
| Cleveland Clinic Lou Ruvo Center for Brain Health | Las Vegas | Nevada | 89106 | — |
| University of Cincinnati | Cincinnati | Ohio | 45219 | — |
| The Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| Pennsylvania Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Medical University of South Carolina (MUSC) | Charleston | South Carolina | 29425 | — |
| Veracity Neuroscience, LLC | Memphis | Tennessee | 38157 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| Kerwin Medical Center | Dallas | Texas | 75231 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Central Texas Neurology Consultants | Round Rock | Texas | 78681 | — |
| University of Utah Movement Disorders Center | Salt Lake City | Utah | 84108 | — |
| Virginia Commonwealth University Department of Neurology | Richmond | Virginia | 23298-0059 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 27 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06122662, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 30, 2026 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06122662 live on ClinicalTrials.gov.