ClinicalTrials.gov record
Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)
ClinicalTrials.gov ID: NCT06126276
Public ClinicalTrials.gov record NCT06126276. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 8, 2026, 4:31 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Trial of Neratinib, A Pan-ERBB Inhibitor, Alone or in Combination With Palbociclib, a CDK4/6 Inhibitor, in Patients With HER2+ Gynecologic Cancers and Other Solid Tumors: A ComboMATCH Treatment Trial
Study identification
- NCT ID
- NCT06126276
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- National Cancer Institute (NCI)
- NIH
- Enrollment
- 70 participants
Conditions and interventions
Conditions
Interventions
- Biopsy Procedure Procedure
- Biospecimen Collection Procedure
- Computed Tomography Procedure
- Echocardiography Test Procedure
- Magnetic Resonance Imaging Procedure
- Multigated Acquisition Scan Procedure
- Neratinib Maleate Drug
- Palbociclib Drug
Procedure · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 6, 2024
- Primary completion
- Feb 19, 2027
- Completion
- Feb 19, 2027
- Last update posted
- May 6, 2026
2024 – 2027
United States locations
- U.S. sites
- 186
- U.S. states
- 32
- U.S. cities
- 152
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | 35233 | Recruiting |
| University of South Alabama Mitchell Cancer Institute | Mobile | Alabama | 36688 | Recruiting |
| Alaska Women's Cancer Care | Anchorage | Alaska | 99508 | Recruiting |
| UC San Diego Health System - Encinitas | Encinitas | California | 92024 | Recruiting |
| UC San Diego Moores Cancer Center | La Jolla | California | 92093 | Recruiting |
| The Angeles Clinic and Research Institute - West Los Angeles Office | Los Angeles | California | 90025 | Recruiting |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | Recruiting |
| UC San Diego Medical Center - Hillcrest | San Diego | California | 92103 | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Aventura | Aventura | Florida | 33180 | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables | Florida | 33146 | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Coral Springs | Coral Springs | Florida | 33065 | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach | Florida | 33442 | Recruiting |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | 33136 | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Kendall | Miami | Florida | 33176 | Recruiting |
| University of Miami Sylvester Comprehensive Cancer Center at Sole Mia | North Miami | Florida | 33181 | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Plantation | Plantation | Florida | 33324 | Recruiting |
| Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | 83706 | Recruiting |
| Saint Luke's Cancer Institute - Boise | Boise | Idaho | 83712 | Recruiting |
| Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho | 83605 | Recruiting |
| Kootenai Health - Coeur d'Alene | Coeur d'Alene | Idaho | 83814 | Recruiting |
| Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho | 83619 | Recruiting |
| Saint Luke's Cancer Institute - Meridian | Meridian | Idaho | 83642 | Recruiting |
| Saint Alphonsus Cancer Care Center-Nampa | Nampa | Idaho | 83687 | Recruiting |
| Saint Luke's Cancer Institute - Nampa | Nampa | Idaho | 83687 | Recruiting |
| Kootenai Clinic Cancer Services - Post Falls | Post Falls | Idaho | 83854 | Recruiting |
| Kootenai Clinic Cancer Services - Sandpoint | Sandpoint | Idaho | 83864 | Recruiting |
| SIH Cancer Institute | Carterville | Illinois | 62918 | Recruiting |
| John H Stroger Jr Hospital of Cook County | Chicago | Illinois | 60612 | Suspended |
| University of Illinois | Chicago | Illinois | 60612 | Recruiting |
| Carle at The Riverfront | Danville | Illinois | 61832 | Recruiting |
| Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois | 62526 | Recruiting |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | Recruiting |
| Carle Physician Group-Effingham | Effingham | Illinois | 62401 | Recruiting |
| Crossroads Cancer Center | Effingham | Illinois | 62401 | Recruiting |
| NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois | 60201 | Recruiting |
| NorthShore University HealthSystem-Glenbrook Hospital | Glenview | Illinois | 60026 | Recruiting |
| NorthShore University HealthSystem-Highland Park Hospital | Highland Park | Illinois | 60035 | Recruiting |
| Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | 61938 | Recruiting |
| Carle BroMenn Medical Center | Normal | Illinois | 61761 | Recruiting |
| Carle Cancer Institute Normal | Normal | Illinois | 61761 | Recruiting |
| Cancer Care Center of O'Fallon | O'Fallon | Illinois | 62269 | Recruiting |
| Mercyhealth Cancer Institute - Rockford | Rockford | Illinois | 61114 | Recruiting |
| Southern Illinois University School of Medicine | Springfield | Illinois | 62702 | Recruiting |
| Springfield Clinic | Springfield | Illinois | 62702 | Recruiting |
| Springfield Memorial Hospital | Springfield | Illinois | 62781 | Recruiting |
| Carle Cancer Center | Urbana | Illinois | 61801 | Recruiting |
| Woodland Cancer Care Center | Michigan City | Indiana | 46360 | Recruiting |
| UI Health Care Mission Cancer and Blood - Ankeny Clinic | Ankeny | Iowa | 50023 | Recruiting |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic | Des Moines | Iowa | 50309 | Recruiting |
| UI Health Care Mission Cancer and Blood - Laurel Clinic | Des Moines | Iowa | 50314 | Recruiting |
| UI Health Care Mission Cancer and Blood - Waukee Clinic | Waukee | Iowa | 50263 | Recruiting |
| Saint Joseph Hospital East | Lexington | Kentucky | 40509 | Recruiting |
| University of Kentucky/Markey Cancer Center | Lexington | Kentucky | 40536 | Recruiting |
| Harold Alfond Center for Cancer Care | Augusta | Maine | 04330 | Recruiting |
| Lafayette Family Cancer Center-EMMC | Brewer | Maine | 04412 | Recruiting |
| MaineHealth Maine Medical Center- Scarborough | Scarborough | Maine | 04074 | Recruiting |
| University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | 21201 | Recruiting |
| Walter Reed National Military Medical Center | Bethesda | Maryland | 20889-5600 | Recruiting |
| National Institutes of Health Clinical Center | Bethesda | Maryland | 20892 | Recruiting |
| UPMC Western Maryland | Cumberland | Maryland | 21502 | Recruiting |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor | Ann Arbor | Michigan | 48106 | Recruiting |
| Trinity Health IHA Medical Group Hematology Oncology - Brighton | Brighton | Michigan | 48114 | Recruiting |
| Trinity Health IHA Medical Group Hematology Oncology - Canton | Canton | Michigan | 48188 | Recruiting |
| Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital | Chelsea | Michigan | 48118 | Recruiting |
| Corewell Health Dearborn Hospital | Dearborn | Michigan | 48124 | Suspended |
| OSF Saint Francis Hospital and Medical Group | Escanaba | Michigan | 49829 | Recruiting |
| Corewell Health Farmington Hills Hospital | Farmington Hills | Michigan | 48336 | Suspended |
| Cancer Hematology Centers - Flint | Flint | Michigan | 48503 | Recruiting |
| Genesee Hematology Oncology PC | Flint | Michigan | 48503 | Suspended |
| Genesys Hurley Cancer Institute | Flint | Michigan | 48503 | Recruiting |
| Hurley Medical Center | Flint | Michigan | 48503 | Recruiting |
| University of Michigan Health - Sparrow Lansing | Lansing | Michigan | 48912 | Recruiting |
| Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan | 48154 | Recruiting |
| Trinity Health Saint Joseph Mercy Oakland Hospital | Pontiac | Michigan | 48341 | Recruiting |
| Corewell Health William Beaumont University Hospital | Royal Oak | Michigan | 48073 | Suspended |
| Corewell Health Beaumont Troy Hospital | Troy | Michigan | 48085 | Suspended |
| Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus | Ypsilanti | Michigan | 48197 | Recruiting |
| Sanford Joe Lueken Cancer Center | Bemidji | Minnesota | 56601 | Recruiting |
| Essentia Health - Deer River Clinic | Deer River | Minnesota | 56636 | Recruiting |
| Essentia Health Cancer Center | Duluth | Minnesota | 55805 | Recruiting |
| Essentia Health Hibbing Clinic | Hibbing | Minnesota | 55746 | Recruiting |
| Saint John's Hospital - Healtheast | Maplewood | Minnesota | 55109 | Recruiting |
| Mayo Clinic in Rochester | Rochester | Minnesota | 55905 | Recruiting |
| Essentia Health Sandstone | Sandstone | Minnesota | 55072 | Recruiting |
| Essentia Health Virginia Clinic | Virginia | Minnesota | 55792 | Recruiting |
| Saint Francis Medical Center | Cape Girardeau | Missouri | 63703 | Recruiting |
| Community Hospital of Anaconda | Anaconda | Montana | 59711 | Recruiting |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | Recruiting |
| Bozeman Health Deaconess Hospital | Bozeman | Montana | 59715 | Recruiting |
| Benefis Sletten Cancer Institute | Great Falls | Montana | 59405 | Recruiting |
| Logan Health Medical Center | Kalispell | Montana | 59901 | Recruiting |
| Community Medical Center | Missoula | Montana | 59804 | Recruiting |
| OptumCare Cancer Care at Charleston | Las Vegas | Nevada | 89102 | Recruiting |
| OptumCare Cancer Care at Fort Apache | Las Vegas | Nevada | 89183 | Recruiting |
| Jersey City Medical Center | Jersey City | New Jersey | 07302 | Recruiting |
| Monmouth Medical Center Southern Campus | Lakewood | New Jersey | 08701 | Recruiting |
| Monmouth Medical Center | Long Branch | New Jersey | 07740 | Recruiting |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08903 | Recruiting |
| Community Medical Center | Toms River | New Jersey | 08755 | Recruiting |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | Recruiting |
| State University of New York Upstate Medical University | Syracuse | New York | 13210 | Recruiting |
| Cone Health MedCenter Asheboro | Asheboro | North Carolina | 27205 | Recruiting |
| Cone Health Cancer Center at Alamance Regional | Burlington | North Carolina | 27215 | Recruiting |
| Southeastern Medical Oncology Center-Clinton | Clinton | North Carolina | 28328 | Recruiting |
| Duke University Medical Center | Durham | North Carolina | 27710 | Recruiting |
| Southeastern Medical Oncology Center-Goldsboro | Goldsboro | North Carolina | 27534 | Recruiting |
| Cone Health Cancer Center | Greensboro | North Carolina | 27403 | Recruiting |
| Cone Health Cancer Center at Drawbridge Parkway | Greensboro | North Carolina | 27410 | Recruiting |
| Southeastern Medical Oncology Center-Jacksonville | Jacksonville | North Carolina | 28546 | Recruiting |
| Duke Women's Cancer Care Raleigh | Raleigh | North Carolina | 27607 | Recruiting |
| Annie Penn Memorial Hospital | Reidsville | North Carolina | 27320 | Recruiting |
| Sanford Bismarck Medical Center | Bismarck | North Dakota | 58501 | Recruiting |
| Sanford Broadway Medical Center | Fargo | North Dakota | 58122 | Recruiting |
| Sanford Roger Maris Cancer Center | Fargo | North Dakota | 58122 | Recruiting |
| OhioHealth O'Bleness Hospital | Athens | Ohio | 45701 | Recruiting |
| Miami Valley Hospital South | Centerville | Ohio | 45459 | Recruiting |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | Recruiting |
| Columbus Oncology and Hematology Associates Inc | Columbus | Ohio | 43214 | Recruiting |
| Riverside Methodist Hospital | Columbus | Ohio | 43214 | Recruiting |
| Grant Medical Center | Columbus | Ohio | 43215 | Recruiting |
| Doctors Hospital | Columbus | Ohio | 43228 | Recruiting |
| Miami Valley Hospital | Dayton | Ohio | 45409 | Recruiting |
| Premier Blood and Cancer Center | Dayton | Ohio | 45409 | Recruiting |
| Dayton Physician LLC - Englewood | Dayton | Ohio | 45415 | Suspended |
| Miami Valley Hospital North | Dayton | Ohio | 45415 | Recruiting |
| Delaware Health Center-Grady Cancer Center | Delaware | Ohio | 43015 | Recruiting |
| Grady Memorial Hospital | Delaware | Ohio | 43015 | Recruiting |
| Columbus Oncology and Hematology Associates | Dublin | Ohio | 43016 | Recruiting |
| Dublin Methodist Hospital | Dublin | Ohio | 43016 | Recruiting |
| Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio | 45005-1066 | Recruiting |
| Miami Valley Cancer Care and Infusion | Greenville | Ohio | 45331 | Recruiting |
| Kettering Medical Center | Kettering | Ohio | 45429 | Suspended |
| OhioHealth Mansfield Hospital | Mansfield | Ohio | 44903 | Recruiting |
| OhioHealth Marion General Hospital | Marion | Ohio | 43302 | Recruiting |
| OhioHealth Pickerington Methodist Hospital | Pickerington | Ohio | 43147 | Recruiting |
| Upper Valley Medical Center | Troy | Ohio | 45373 | Recruiting |
| OhioHealth Westerville Medical Campus/Westerville Cancer Center | Westerville | Ohio | 43082 | Recruiting |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | Recruiting |
| Saint Alphonsus Cancer Care Center-Ontario | Ontario | Oregon | 97914 | Recruiting |
| Providence Portland Medical Center | Portland | Oregon | 97213 | Recruiting |
| Providence Saint Vincent Medical Center | Portland | Oregon | 97225 | Recruiting |
| UPMC Altoona | Altoona | Pennsylvania | 16601 | Recruiting |
| UPMC Hillman Cancer Center Erie | Erie | Pennsylvania | 16505 | Recruiting |
| UPMC Cancer Centers - Arnold Palmer Pavilion | Greensburg | Pennsylvania | 15601 | Recruiting |
| UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion | Mechanicsburg | Pennsylvania | 17050 | Recruiting |
| UPMC Hillman Cancer Center - Monroeville | Monroeville | Pennsylvania | 15146 | Recruiting |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | Recruiting |
| UPMC-Magee Womens Hospital | Pittsburgh | Pennsylvania | 15213 | Recruiting |
| University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh | Pennsylvania | 15232 | Recruiting |
| UPMC-Passavant Hospital | Pittsburgh | Pennsylvania | 15237 | Recruiting |
| Asplundh Cancer Pavilion | Willow Grove | Pennsylvania | 19090 | Recruiting |
| Women and Infants Hospital | Providence | Rhode Island | 02905 | Recruiting |
| Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota | 57104 | Recruiting |
| Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | 57117-5134 | Recruiting |
| Bristol Regional Medical Center | Bristol | Tennessee | 37620 | Recruiting |
| Regional Cancer Center at Johnson City Medical Center | Johnson City | Tennessee | 37604 | Recruiting |
| Ballad Health Cancer Care - Kingsport | Kingsport | Tennessee | 37660 | Recruiting |
| Wellmont Holston Valley Hospital and Medical Center | Kingsport | Tennessee | 37660 | Recruiting |
| Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee | 37232 | Recruiting |
| UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | 75390 | Recruiting |
| M D Anderson Cancer Center | Houston | Texas | 77030 | Recruiting |
| Scott and White Memorial Hospital | Temple | Texas | 76508 | Recruiting |
| Ballad Health Cancer Care - Bristol | Bristol | Virginia | 24201 | Recruiting |
| University of Virginia Cancer Center | Charlottesville | Virginia | 22908 | Recruiting |
| Inova Schar Cancer Institute | Fairfax | Virginia | 22031 | Recruiting |
| Inova Fairfax Hospital | Falls Church | Virginia | 22042 | Recruiting |
| VCU Massey Comprehensive Cancer Center | Richmond | Virginia | 23298 | Recruiting |
| Carilion Roanoke Memorial Hospital | Roanoke | Virginia | 24033 | Recruiting |
| Swedish Cancer Institute-Edmonds | Edmonds | Washington | 98026 | Recruiting |
| Swedish Cancer Institute-Issaquah | Issaquah | Washington | 98029 | Recruiting |
| Swedish Medical Center-First Hill | Seattle | Washington | 98122 | Recruiting |
| West Virginia University Healthcare | Morgantown | West Virginia | 26506 | Recruiting |
| Duluth Clinic Ashland | Ashland | Wisconsin | 54806 | Recruiting |
| Marshfield Medical Center-EC Cancer Center | Eau Claire | Wisconsin | 54701 | Recruiting |
| Saint Vincent Hospital Cancer Center Green Bay | Green Bay | Wisconsin | 54301 | Recruiting |
| Saint Vincent Hospital Cancer Center at Saint Mary's | Green Bay | Wisconsin | 54303 | Recruiting |
| Gundersen Lutheran Medical Center | La Crosse | Wisconsin | 54601 | Recruiting |
| Marshfield Medical Center-Marshfield | Marshfield | Wisconsin | 54449 | Recruiting |
| Marshfield Medical Center - Minocqua | Minocqua | Wisconsin | 54548 | Recruiting |
| Cancer Center of Western Wisconsin | New Richmond | Wisconsin | 54017 | Recruiting |
| Saint Vincent Hospital Cancer Center at Oconto Falls | Oconto Falls | Wisconsin | 54154 | Recruiting |
| Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin | 54868 | Recruiting |
| Saint Vincent Hospital Cancer Center at Sheboygan | Sheboygan | Wisconsin | 53081 | Recruiting |
| Marshfield Medical Center-River Region at Stevens Point | Stevens Point | Wisconsin | 54482 | Recruiting |
| Saint Vincent Hospital Cancer Center at Sturgeon Bay | Sturgeon Bay | Wisconsin | 54235-1495 | Recruiting |
| Marshfield Medical Center - Weston | Weston | Wisconsin | 54476 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06126276, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 6, 2026 · Synced May 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06126276 live on ClinicalTrials.gov.