Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen

ClinicalTrials.gov ID: NCT06127407

Public ClinicalTrials.gov record NCT06127407. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jul 21, 2026, 12:35 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled Study of Ivosidenib in Participants ≥18 Years of Age With Locally Advanced or Metastatic Conventional Chondrosarcoma With an IDH1 Mutation, Untreated or Previously Treated With 1 Systemic Treatment Regimen

Study identification

NCT ID: NCT06127407
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Servier Bio-Innovation LLC; Industry
Enrollment: 136 participants

Conditions and interventions

Conditions

Locally Advanced or Metastatic Conventional Chondrosarcoma With an IDH1 Mutation, Untreated or Previously Treated With 1 Systemic Treatment Regimen

Interventions

Ivosidenib 500mg Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jul 8, 2024
Primary completion: Jan 31, 2028
Completion: Nov 25, 2030
Last update posted: Feb 5, 2026

2024 – 2030

United States locations

U.S. sites: 22
U.S. states: 19
U.S. cities: 22

Facility	City	State	ZIP	Site status
Usc Norris Comprehensive Cancer Center	Los Angeles	California	90033	Recruiting
Sarcoma Oncology Research Center	Santa Monica	California	90403	Recruiting
University of Colorado Cancer Center	Aurora	Colorado	80045	Recruiting
Yale Cancer Center	New Haven	Connecticut	06511	Recruiting
Mayo Clinic - Jacksonville, Fl	Jacksonville	Florida	32224	Recruiting
University of Miami	Miami	Florida	33136-1002	Recruiting
Emory Winship Cancer Institute	Atlanta	Georgia	30308	Recruiting
Robert H. Lurie Comprehensive Cancer Center of Northwestern University	Chicago	Illinois	60611-5975	Recruiting
University of Iowa Hospitals & Clinics- Holden Comprehensive Cancer Center	Iowa City	Iowa	52242	Recruiting
Johns Hopkins University	Baltimore	Maryland	21287	Recruiting
Dana-Farber Cancer Institute	Boston	Massachusetts	02215	Recruiting
Mayo Clinic - Rochester, Mn	Rochester	Minnesota	55905	Recruiting
The Washington University	St Louis	Missouri	63110	Recruiting
Nebraska Methodist Hospital	Omaha	Nebraska	68118	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
Duke University	Durham	North Carolina	27710	Recruiting
Cleveland Clinic	Cleveland	Ohio	44195	Recruiting
The Ohio State University Comprehensive Cancer Center	Columbus	Ohio	43210	Recruiting
Oregon Health & Science University Knight Cancer Institute	Portland	Oregon	97239	Recruiting
University of Pittsburgh Medical Center-Hillman Cancer Center	Pittsburgh	Pennsylvania	15232	Recruiting
Vanderbilt University Medical Center	Nashville	Tennessee	37232	Recruiting
The Univeristy of Texas Md Anderson Cancer Center	Houston	Texas	77030	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 91 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06127407, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Feb 5, 2026 · Synced Jul 21, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06127407 live on ClinicalTrials.gov.

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