MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)
Public ClinicalTrials.gov record NCT06128629. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
MAGNITUDE: A Phase 3, Multinational, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)
Study identification
- NCT ID
- NCT06128629
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Intellia Therapeutics
- Industry
- Enrollment
- 1,200 participants
Conditions and interventions
Interventions
- NTLA-2001 Biological
- Placebo Drug
Biological · Drug
Eligibility (public fields only)
- Age range
- 18 Years to 90 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 12, 2023
- Primary completion
- Nov 30, 2027
- Completion
- Mar 31, 2028
- Last update posted
- Mar 26, 2026
2023 – 2028
United States locations
- U.S. sites
- 38
- U.S. states
- 23
- U.S. cities
- 32
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Arizona | Tucson | Arizona | 85724 | Recruiting |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | Recruiting |
| Western Greater Los Angeles VA Medical Center | Los Angeles | California | 90073 | Recruiting |
| Stanford University | Palo Alto | California | 94305 | Recruiting |
| University of California, San Diego (UCSD) - Medical Center | San Diego | California | 92103 | Recruiting |
| University of Colorado Denver | Denver | Colorado | 80045 | Recruiting |
| Yale University School of Medicine | New Haven | Connecticut | 06510 | Recruiting |
| MedStar Washington Hospital Center - MedStar Heart and Vascular Institute | Washington D.C. | District of Columbia | 20010 | Recruiting |
| Mayo Clinic - Jacksonville | Jacksonville | Florida | 32224 | Recruiting |
| Cleveland Clinic of Florida | Weston | Florida | 33331 | Recruiting |
| Emory University School of Medicine | Atlanta | Georgia | 30322 | Recruiting |
| Northwestern University | Chicago | Illinois | 60611 | Recruiting |
| Indiana University Health | Indianapolis | Indiana | 46202 | Recruiting |
| University of Kentucky Gill Heart Institute | Lexington | Kentucky | 40536 | Recruiting |
| Johns Hopkins University | Baltimore | Maryland | 21287 | Recruiting |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | Recruiting |
| Boston University School of Medicine | Boston | Massachusetts | 02118 | Recruiting |
| University of Michigan | Ann Arbor | Michigan | 48109 | Recruiting |
| Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | 48201 | Withdrawn |
| Mayo Clinic | Rochester | Minnesota | 55905 | Recruiting |
| St. Luke's Hospital | Kansas City | Missouri | 64111 | Recruiting |
| New York University (NYU) School of Medicine - Langone Medical Center | New York | New York | 10016 | Recruiting |
| Columbia University Medical Center | New York | New York | 10032 | Recruiting |
| Duke University Medical Center | Durham | North Carolina | 27710 | Recruiting |
| Cleveland Clinic | Cleveland | Ohio | 44195 | Recruiting |
| Ohio Health Research Institute | Columbus | Ohio | 43214 | Recruiting |
| Oregon Health and Science University (OHSU) | Portland | Oregon | 97239 | Recruiting |
| Penn Presbyterian Medical Center | Philadelphia | Pennsylvania | 19104 | Recruiting |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | Recruiting |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | 15219 | Recruiting |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | Recruiting |
| Baylor Scott & White Research Institute | Dallas | Texas | 75201 | Recruiting |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | Recruiting |
| Baylor College of Medicine | Houston | Texas | 77030 | Recruiting |
| Houston Methodist Hospital | Houston | Texas | 77030 | Recruiting |
| Baylor Scott and White - The Heart Hospital Baylor Plano | Plano | Texas | 75093 | Recruiting |
| INOVA Fairfax Hospital | Falls Church | Virginia | 22042 | Recruiting |
| Virginia Commonwealth University - Department of Internal Medicine | Richmond | Virginia | 23298 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 94 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06128629, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 26, 2026 · Synced Jul 22, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06128629 live on ClinicalTrials.gov.