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Recruiting Phase 3 Interventional

A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy

ClinicalTrials.gov ID: NCT06129864

Public ClinicalTrials.gov record NCT06129864. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 1, 2026, 7:20 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase III, Randomized, Open-Label, Multi-Center, Global Study of Volrustomig (MEDI5752) as Sequential Therapy Versus Observation in Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma, Who Have Not Progressed Following Definitive Concurrent Chemoradiotherapy (eVOLVE-HNSCC)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The main purpose of this study is to assess the efficacy and safety of volrustomig compared to observation in participants with unresected locally advanced head and neck squamous cell carcinoma (LA-HNSCC) who have not progressed after receiving definitive concurrent chemoradiotherapy (cCRT).

Study identification

NCT ID
NCT06129864
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
AstraZeneca
Industry
Enrollment
1,145 participants

Conditions and interventions

Interventions

Drug

Eligibility (public fields only)

Age range
18 Years to 130 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Dec 13, 2023
Primary completion
Apr 16, 2030
Completion
Feb 27, 2031
Last update posted
Aug 5, 2026

2023 – 2031

United States locations

U.S. sites
69
U.S. states
30
U.S. cities
64
Facility City State ZIP Site status
Research Site Birmingham Alabama 35233 Recruiting
Research Site Phoenix Arizona 85028 Recruiting
Research Site Prescott Valley Arizona 86314 Active, not recruiting
Research Site Springdale Arkansas 72762 Withdrawn
Research Site Fountain Valley California 92708 Recruiting
Research Site Los Angeles California 90024 Recruiting
Research Site Orange California 92868 Withdrawn
Research Site San Francisco California 94143 Recruiting
Research Site Santa Rosa California 95403 Recruiting
Research Site Whittier California 90602 Recruiting
Research Site Aurora Colorado 80045 Recruiting
Research Site Colorado Springs Colorado 80909 Recruiting
Research Site Lone Tree Colorado 80124 Recruiting
Research Site Washington D.C. District of Columbia 20037 Recruiting
Research Site Fort Myers Florida 33901 Recruiting
Research Site Gainesville Florida 32610 Withdrawn
Research Site Miami Florida 33125 Withdrawn
Research Site Palm Bay Florida 32909 Recruiting
Research Site West Palm Beach Florida 33401 Recruiting
Research Site Niles Illinois 60714 Recruiting
Research Site Des Moines Iowa 50309 Recruiting
Research Site Kansas City Kansas 66160 Completed
Research Site Louisville Kentucky 40202 Recruiting
Research Site Baton Rouge Louisiana 70817 Recruiting
Research Site Shreveport Louisiana 71101 Withdrawn
Research Site Baltimore Maryland 21231 Recruiting
Research Site Bethesda Maryland 20817 Recruiting
Research Site Hyattsville Maryland 20782 Recruiting
Research Site Towson Maryland 21204 Recruiting
Research Site Upper Marlboro Maryland 20774 Recruiting
Research Site Boston Massachusetts 02215 Recruiting
Research Site Fairhaven Massachusetts 02719 Recruiting
Research Site Ann Arbor Michigan 48105 Recruiting
Research Site Ann Arbor Michigan 48109 Withdrawn
Research Site Minneapolis Minnesota 55417 Recruiting
Research Site Columbia Missouri 65211 Withdrawn
Research Site St Louis Missouri 63110 Withdrawn
Research Site East Brunswick New Jersey 08816 Withdrawn
Research Site Hackensack New Jersey 07601 Recruiting
Research Site New Brunswick New Jersey 08901 Active, not recruiting
Research Site Albuquerque New Mexico 87108 Active, not recruiting
Research Site New York New York 10065 Recruiting
Research Site New York New York 10075 Recruiting
Research Site Stony Brook New York 11794 Recruiting
Research Site Charlotte North Carolina 28204 Recruiting
Research Site Winston-Salem North Carolina 27157 Recruiting
Research Site Cleveland Ohio 44106 Withdrawn
Research Site Portland Oregon 97213 Withdrawn
Research Site Portland Oregon 97239 Completed
Research Site Philadelphia Pennsylvania 19107 Withdrawn
Research Site Pittsburgh Pennsylvania 15261 Recruiting
Research Site York Pennsylvania 17403 Recruiting
Research Site Sioux Falls South Dakota 57104 Recruiting
Research Site Sioux Falls South Dakota 57105 Recruiting
Research Site Nashville Tennessee 37212 Recruiting
Research Site Austin Texas 78745 Recruiting
Research Site Dallas Texas 75251 Recruiting
Research Site Flower Mound Texas 75028 Withdrawn
Research Site Houston Texas 77030 Withdrawn
Research Site Odessa Texas 79761 Recruiting
Research Site Tyler Texas 75702 Withdrawn
Research Site Salt Lake City Utah 84112 Recruiting
Research Site West Jordan Utah 84088 Recruiting
Research Site Fairfax Virginia 22031 Recruiting
Research Site Norfolk Virginia 23502 Recruiting
Research Site Richmond Virginia 23230 Withdrawn
Research Site Spokane Washington 99204 Withdrawn
Research Site Tacoma Washington 98405 Withdrawn
Research Site Tacoma Washington 98415 Active, not recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 235 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06129864, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Aug 5, 2026 · Synced Sep 1, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06129864 live on ClinicalTrials.gov.

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