Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial Cancer (MK-2870-005)
Public ClinicalTrials.gov record NCT06132958. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Active-controlled, Open-label, Multicenter Study to Compare the Efficacy and Safety of MK-2870 Monotherapy Versus Treatment of Physician's Choice in Participants With Endometrial Cancer Who Have Received Prior Platinum-based Chemotherapy and Immunotherapy (MK-2870-005/ENGOT-en23/GOG-3095)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Researchers are looking for new ways to treat people with endometrial cancer (EC) who have previously received treatment with platinum based therapy (a type of chemotherapy) and immunotherapy. Immunotherapy is a treatment that helps the immune system fight cancer. This clinical study will compare sacituzumab tirumotecan to chemotherapy. The goal of the study is to learn if people who receive sacituzumab tirumotecan live longer overall and without the cancer getting worse compared to people who receive chemotherapy.
Study identification
- NCT ID
- NCT06132958
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 710 participants
Conditions and interventions
Conditions
Interventions
- Sacituzumab tirumotecan Biological
- Doxorubicin Drug
- Paclitaxel Drug
- Nab-paclitaxel Drug
- Rescue medications Drug
Biological · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 6, 2023 (Actual)
- Primary completion
- Jan 10, 2028 (Estimated)
- Completion
- Jan 10, 2028 (Estimated)
- Last update posted
- Aug 28, 2026
2023 – 2028
United States locations
- U.S. sites
- 43
- U.S. states
- 25
- U.S. cities
- 42
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| USA Mitchell Cancer Institute ( Site 4142) | Mobile | Alabama | 36604 | — |
| Alaska Womens Cancer Care ( Site 4122) | Anchorage | Alaska | 99508 | — |
| HonorHealth (HH) ( Site 8000) | Phoenix | Arizona | 85016 | — |
| Arizona Oncology Associates - HOPE ( Site 8002) | Tucson | Arizona | 85711 | — |
| UCLA Hematology/Oncology - Westwood (Building 100)-Department of OBGYN, Division of Gynecologic Onc ( Site 4131) | Los Angeles | California | 90095 | — |
| California Pacific Medical Center - Van Ness Campus ( Site 4129) | San Francisco | California | 94109 | — |
| Yale-New Haven Hospital-Smilow Cancer Hospital at Yale-New Haven ( Site 4114) | New Haven | Connecticut | 06511 | — |
| MedStar Washington Hospital Center ( Site 4108) | Washington D.C. | District of Columbia | 20010 | — |
| Mount Sinai Cancer Center ( Site 4117) | Miami Beach | Florida | 33140 | — |
| AdventHealth Orlando-AdventHealth Medical Group Gynecological Oncology ( Site 4113) | Orlando | Florida | 32804 | — |
| Florida Cancer Specialists - East ( Site 7000) | West Palm Beach | Florida | 33401 | — |
| Northside Hospital ( Site 4112) | Atlanta | Georgia | 30342 | — |
| Augusta University ( Site 4116) | Augusta | Georgia | 30912 | — |
| Centricity Research Columbus Cancer Center ( Site 4154) | Columbus | Georgia | 31904 | — |
| NorthShore University HealthSystem - Evanston Hospital ( Site 4110) | Evanston | Illinois | 60201 | — |
| Parkview Research Center at Parkview Regional Medical Center ( Site 4132) | Fort Wayne | Indiana | 46845 | — |
| Saint Elizabeth Medical Center Edgewood-Cancer Care Center ( Site 4150) | Edgewood | Kentucky | 41017 | — |
| University Medical Center New Orleans ( Site 4133) | New Orleans | Louisiana | 70112 | — |
| TRIALS 365 ( Site 4105) | Shreveport | Louisiana | 71103 | — |
| University of Massachusetts Memorial Medical Center ( Site 4103) | Worcester | Massachusetts | 01605 | — |
| Washington University School of Medicine-Obstetrics & Gynecology ( Site 4146) | St Louis | Missouri | 63110 | — |
| The Center of Hope ( Site 4109) | Reno | Nevada | 89511 | — |
| John Theurer Cancer Center at Hackensack University Medical Center ( Site 4118) | Hackensack | New Jersey | 07601 | — |
| Atlantic Health System Morristown Medical Center ( Site 4135) | Morristown | New Jersey | 07960 | — |
| Holy Name Medical Center ( Site 4115) | Teaneck | New Jersey | 07666 | — |
| New York - Presbyterian Brooklyn Methodist Hospital ( Site 4134) | Brooklyn | New York | 11215 | — |
| Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 4156) | Mineola | New York | 11501 | — |
| Laura and Isaac Perlmutter Cancer Center ( Site 4106) | New York | New York | 10016 | — |
| Icahn School of Medicine at Mount Sinai-Department of Obstetrics, Gynecology, and Reproductive Scie ( Site 4128) | New York | New York | 10029 | — |
| Good Samaritan Hospital Medical Center ( Site 4139) | West Islip | New York | 11795 | — |
| Duke Cancer Institute ( Site 4120) | Durham | North Carolina | 27710 | — |
| Sanford Health Roger Maris Cancer Center ( Site 4158) | Fargo | North Dakota | 58102 | — |
| University of Cincinnati Medical Center ( Site 4136) | Cincinnati | Ohio | 45219 | — |
| The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C (Site 4125) | Columbus | Ohio | 43210 | — |
| Sidney Kimmel Cancer Center - Jefferson Health ( Site 4157) | Philadelphia | Pennsylvania | 19107 | — |
| AHN West Penn Hospital-Gynecologic Oncology ( Site 4111) | Pittsburgh | Pennsylvania | 15244 | — |
| Asplundh Cancer Pavilion ( Site 4107) | Willow Grove | Pennsylvania | 19090 | — |
| Women & Infants Hospital ( Site 4138) | Providence | Rhode Island | 02905 | — |
| Sanford Cancer Center-Gynecologic Oncology ( Site 4121) | Sioux Falls | South Dakota | 57104 | — |
| The West Clinic, PLLC dba West Cancer Center ( Site 4102) | Germantown | Tennessee | 38138 | — |
| Houston Methodist Hospital-Obstetrics and Gynecology ( Site 4130) | Houston | Texas | 77030 | — |
| Texas Oncology - San Antonio ( Site 8005) | San Antonio | Texas | 78240 | — |
| Texas Oncology - Gulf Coast ( Site 8006) | The Woodlands | Texas | 77380 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 199 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06132958, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 28, 2026 · Synced Oct 28, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06132958 live on ClinicalTrials.gov.