ClinicalTrials.gov record
Efficacy and Safety Studies of Frexalimab (SAR441344) in Adults With Relapsing Forms of Multiple Sclerosis
ClinicalTrials.gov ID: NCT06141473
Public ClinicalTrials.gov record NCT06141473. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 4, 2026, 12:16 PM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Master Protocol of Two Independent, Randomized, Double-blind, Phase 3 Studies Comparing Efficacy and Safety of Frexalimab (SAR441344) to Teriflunomide in Adult Participants With Relapsing Forms of Multiple Sclerosis
Study identification
- NCT ID
- NCT06141473
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Sanofi
- Industry
- Enrollment
- 1,600 participants
Conditions and interventions
Conditions
Interventions
- Activated charcoal Drug
- Cholestyramine Drug
- Frexalimab Drug
- MRI contrast-enhancing agents Drug
- Placebo infusion Drug
- Placebo tablet Drug
- Teriflunomide Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 55 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 12, 2023
- Primary completion
- May 5, 2027
- Completion
- May 5, 2027
- Last update posted
- Apr 12, 2026
2023 – 2027
United States locations
- U.S. sites
- 99
- U.S. states
- 35
- U.S. cities
- 87
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham- Site Number : 8401135 | Birmingham | Alabama | 35233 | Recruiting |
| North Central Neurology Associates- Site Number : 8401100 | Cullman | Alabama | 35058 | Recruiting |
| Alabama Neurology Associates- Site Number : 8400115 | Homewood | Alabama | 35209 | Recruiting |
| St. Joseph's Hospital and Medical Center- Site Number : 8401139 | Phoenix | Arizona | 85013 | Recruiting |
| Perseverance Research Center- Site Number : 8401138 | Scottsdale | Arizona | 85253 | Recruiting |
| Clinical Endpoints- Site Number : 8400050 | Scottsdale | Arizona | 85258 | Recruiting |
| The Neurology Center of Southern California - Carlsbad- Site Number : 8400023 | Carlsbad | California | 92011 | Recruiting |
| University of California Irvine - School of Medicine- Site Number : 8401143 | Irvine | California | 92697 | Recruiting |
| Multiple Sclerosis Center of California - Laguna Hills- Site Number : 8401122 | Laguna Hills | California | 92653 | Recruiting |
| Chemidox Clinical Trials- Site Number : 8401157 | Lancaster | California | 93534 | Recruiting |
| Hoag Memorial Hospital Presbyterian- Site Number : 8401031 | Newport Beach | California | 92663 | Recruiting |
| Private Practice - Dr. Regina Berkovich- Site Number : 8400005 | West Hollywood | California | 90048 | Recruiting |
| University of Colorado - Anschutz Medical Campus- Site Number : 8401001 | Aurora | Colorado | 80045 | Completed |
| Advanced Neurology of Colorado- Site Number : 8401148 | Fort Collins | Colorado | 80528 | Active, not recruiting |
| Hartford Healthcare Medical Group- Site Number : 8401069 | Norwich | Connecticut | 06360 | Recruiting |
| New England Institute for Clinical Research- Site Number : 8400114 | Stamford | Connecticut | 06905 | Recruiting |
| MedStar Georgetown University Hospital- Site Number : 8400044 | Washington D.C. | District of Columbia | 20007 | Recruiting |
| Neurology of Central Florida- Site Number : 8401147 | Altamonte Springs | Florida | 32714 | Recruiting |
| Neurology Offices of South Florida - Boca Raton- Site Number : 8401169 | Boca Raton | Florida | 33428 | Recruiting |
| First Choice Neurology - Espinosa Neuroscience Institute- Site Number : 8401071 | Boca Raton | Florida | 33486 | Recruiting |
| Nova Clinical Research - Bradenton- Site Number : 8400189 | Bradenton | Florida | 34209 | Recruiting |
| Mayo Clinic in Florida- Site Number : 8401093 | Jacksonville | Florida | 32224 | Recruiting |
| Neurology Associates - Maitland- Site Number : 8400010 | Maitland | Florida | 32751 | Recruiting |
| University of Miami Hospital- Site Number : 8401177 | Miami | Florida | 33136 | Recruiting |
| Design Neuroscience Center- Site Number : 8401191 | Miami Lakes | Florida | 33016 | Recruiting |
| Orlando Health Neuroscience Institute - Downtown Pavilion- Site Number : 8400060 | Orlando | Florida | 32806 | Recruiting |
| Axiom Clinical Research of Florida- Site Number : 8400049 | Tampa | Florida | 33609 | Recruiting |
| University of South Florida- Site Number : 8400013 | Tampa | Florida | 33612 | Recruiting |
| Palm Beach Neurology- Site Number : 8401105 | West Palm Beach | Florida | 33407 | Recruiting |
| Velocity Clinical Research - Savannah Neurology- Site Number : 8400061 | Savannah | Georgia | 31406 | Recruiting |
| Joi Life Wellness Group LLC- Site Number : 8401192 | Smyrna | Georgia | 30080 | Recruiting |
| NorthShore Medical Group - Evanston ( Endeavor Health)- Site Number : 8401111 | Evanston | Illinois | 60201 | Recruiting |
| Consultants in Neurology- Site Number : 8401020 | Northbrook | Illinois | 60062 | Recruiting |
| Springfield Clinic 1st - 900 Building- Site Number : 8400043 | Springfield | Illinois | 62702 | Recruiting |
| IU Health Physicians - Fort Wayne - Hope Drive- Site Number : 8400058 | Fort Wayne | Indiana | 46815 | Recruiting |
| Neuroscience Institute Center- Site Number : 8400053 | Merrillville | Indiana | 46410 | Recruiting |
| University of Iowa- Site Number : 8400029 | Iowa City | Iowa | 52242 | Recruiting |
| University of Kansas Medical Center- Site Number : 8400084 | Kansas City | Kansas | 66160 | Recruiting |
| KC Research Center- Site Number : 8400032 | Roeland Park | Kansas | 66205 | Recruiting |
| Baptist Health Lexington- Site Number : 8401149 | Lexington | Kentucky | 40503 | Recruiting |
| Norton Neurology Services- Site Number : 8401103 | Louisville | Kentucky | 40207 | Recruiting |
| NeuroMedical Clinic of Central Louisiana- Site Number : 8401159 | Alexandria | Louisiana | 71301 | Recruiting |
| The NeuroMedical Center- Site Number : 8401182 | Baton Rouge | Louisiana | 70810 | Recruiting |
| Ochsner Medical Center - Jefferson Highway- Site Number : 8400027 | New Orleans | Louisiana | 70121 | Recruiting |
| International Neurorehabilitation Institute- Site Number : 8400089 | Lutherville | Maryland | 21093 | Recruiting |
| Boston Clinical Trials- Site Number : 8401178 | Boston | Massachusetts | 02131 | Recruiting |
| Beth Israel Deaconess Medical Center - Boston- Site Number : 8401041 | Boston | Massachusetts | 02215 | Recruiting |
| Neurology Center of New England- Site Number : 8401164 | Foxborough | Massachusetts | 02035 | Recruiting |
| Henry Ford Hospital- Site Number : 8401091 | Detroit | Michigan | 48202 | Recruiting |
| Michigan Institute for Neurological Disorders- Site Number : 8400004 | Farmington Hills | Michigan | 48334 | Recruiting |
| Memorial Healthcare Institute for Neuroscience- Site Number : 8400123 | Owosso | Michigan | 48867 | Active, not recruiting |
| Rochester Medical Group- Site Number : 8401172 | Rochester Hills | Michigan | 48307 | Active, not recruiting |
| M Health Fairview University of Minnesota Medical Center - East Bank- Site Number : 8400056 | Minneapolis | Minnesota | 55455 | Recruiting |
| Minnesota Center for Multiple Sclerosis- Site Number : 8400073 | Plymouth | Minnesota | 55446 | Recruiting |
| Sharlin Health and Neurology- Site Number : 8400016 | Ozark | Missouri | 65721 | Recruiting |
| Washington University- Site Number : 8400076 | St Louis | Missouri | 63110 | Recruiting |
| The MS Center for Innovations in Care- Site Number : 8401141 | St Louis | Missouri | 63131 | Recruiting |
| Cleveland Clinic Lou Ruvo Center for Brain Health Las Vegas- Site Number : 8400045 | Las Vegas | Nevada | 89106 | Recruiting |
| Renown Regional Medical Center- Site Number : 8400066 | Reno | Nevada | 89502 | Recruiting |
| Rutgers University- Site Number : 8401067 | New Brunswick | New Jersey | 08903 | Recruiting |
| The University of New Mexico- Site Number : 8401090 | Albuquerque | New Mexico | 87106 | Active, not recruiting |
| South Shore Neurologic Associates - Patchogue- Site Number : 8400063 | Patchogue | New York | 11772 | Recruiting |
| Montefiore Medical Center - Einstein Campus- Site Number : 8401145 | The Bronx | New York | 10461 | Recruiting |
| The Neurological Institute- Site Number : 8401166 | Charlotte | North Carolina | 28204 | Recruiting |
| Piedmont HealthCare - Lake Norman Neurology- Site Number : 8400002 | Charlotte | North Carolina | 28210 | Recruiting |
| Raleigh Neurology Associates- Site Number : 8400014 | Raleigh | North Carolina | 27607 | Recruiting |
| Atrium Health - Wake Forest Baptist - Shepherd- Site Number : 8400040 | Winston-Salem | North Carolina | 27103 | Recruiting |
| Sanford Brain and Spine Center- Site Number : 8401085 | Fargo | North Dakota | 58103 | Active, not recruiting |
| Dayton Center for Neurological Disorders- Site Number : 8400079 | Centerville | Ohio | 45459 | Recruiting |
| University of Cincinnati Medical Center- Site Number : 8401117 | Cincinnati | Ohio | 45219 | Recruiting |
| The Ohio State University- Site Number : 8401009 | Columbus | Ohio | 43210 | Recruiting |
| OhioHealth Riverside Methodist Hospital- Site Number : 8401092 | Columbus | Ohio | 43214 | Recruiting |
| The Boster Center for Multiple Sclerosis- Site Number : 8400006 | Columbus | Ohio | 43235 | Recruiting |
| UC Health - Elizabeth Place- Site Number : 8401008 | Dayton | Ohio | 45408 | Recruiting |
| Oklahoma Medical Research Foundation- Site Number : 8400039 | Oklahoma City | Oklahoma | 73104 | Recruiting |
| Providence St. Vincent's Medical Center- Site Number : 8400052 | Portland | Oregon | 97225 | Recruiting |
| Oregon Neurology Associates- Site Number : 8400188 | Springfield | Oregon | 97477 | Recruiting |
| Abington Neurological Associates- Site Number : 8401065 | Abington | Pennsylvania | 19001 | Recruiting |
| Penn State Health Milton South Hershey Medical Center- Site Number : 8401176 | Hershey | Pennsylvania | 17033 | Recruiting |
| Thomas Jefferson University Hospital- Site Number : 8400035 | Philadelphia | Pennsylvania | 19107 | Recruiting |
| Allegheny General Hospital- Site Number : 8401173 | Pittsburgh | Pennsylvania | 15212 | Recruiting |
| UPMC Magee-Womens Hospital- Site Number : 8401133 | Pittsburgh | Pennsylvania | 15213 | Recruiting |
| Premier Neurology- Site Number : 8401047 | Greer | South Carolina | 29650 | Recruiting |
| Hope Neurology- Site Number : 8400019 | Knoxville | Tennessee | 37922 | Recruiting |
| Neurology Consultants of Dallas - Lyndon B Johnson Freeway- Site Number : 8400152 | Dallas | Texas | 75243 | Recruiting |
| ANESC Research- Site Number : 8400187 | El Paso | Texas | 79912 | Recruiting |
| Baylor College of Medicine Medical Center- Site Number : 8401170 | Houston | Texas | 77030 | Recruiting |
| North Texas Institute of Neurology & Headache - Plano- Site Number : 8401083 | Plano | Texas | 75024 | Recruiting |
| UT Health - San Antonio- Site Number : 8401167 | San Antonio | Texas | 78229 | Recruiting |
| Neurology Center of San Antonio- Site Number : 8400099 | San Antonio | Texas | 78258 | Recruiting |
| Texas Institute for Neurological Disorders - Sherman- Site Number : 8400018 | Sherman | Texas | 75092 | Recruiting |
| Inova Schar Cancer Institute - Fairfax - Innovation Park Drive- Site Number : 8401109 | Fairfax | Virginia | 22031 | Recruiting |
| Multiple Sclerosis Center of Greater Washington (MSCGW)- Site Number : 8401128 | Vienna | Virginia | 22182 | Recruiting |
| Sentara Family Medicine Physicians - Virginia Beach - Glenn Mitchell Drive- Site Number : 8401168 | Virginia Beach | Virginia | 23456 | Recruiting |
| Swedish Medical Center - Seattle- Site Number : 8400078 | Seattle | Washington | 98104 | Recruiting |
| University of Washington Medical Center - Northwest- Site Number : 8401146 | Seattle | Washington | 98133 | Recruiting |
| MultiCare Tacoma General Hospital- Site Number : 8401140 | Tacoma | Washington | 98405 | Completed |
| Wheaton Franciscan Healthcare - St Francis- Site Number : 8400034 | Milwaukee | Wisconsin | 53215 | Recruiting |
| Medical College of Wisconsin - Milwaukee Campus- Site Number : 8400038 | Milwaukee | Wisconsin | 53226 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 285 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06141473, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 12, 2026 · Synced May 4, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06141473 live on ClinicalTrials.gov.