ClinicalTrials.gov record
Efficacy and Safety Studies of Frexalimab (SAR441344) in Adults With Relapsing Forms of Multiple Sclerosis
ClinicalTrials.gov ID: NCT06141473
Public ClinicalTrials.gov record NCT06141473. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Master Protocol of Two Independent, Randomized, Double-blind, Phase 3 Studies Comparing Efficacy and Safety of Frexalimab (SAR441344) to Teriflunomide in Adult Participants With Relapsing Forms of Multiple Sclerosis
Study identification
- NCT ID
- NCT06141473
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Sanofi
- Industry
- Enrollment
- 1,655 participants
Conditions and interventions
Conditions
Interventions
- Activated charcoal Drug
- Cholestyramine Drug
- Frexalimab Drug
- MRI contrast-enhancing agents Drug
- Placebo infusion Drug
- Placebo tablet Drug
- Teriflunomide Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 55 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 12, 2023
- Primary completion
- May 5, 2027
- Completion
- May 5, 2027
- Last update posted
- May 13, 2026
2023 – 2027
United States locations
- U.S. sites
- 99
- U.S. states
- 35
- U.S. cities
- 87
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham- Site Number : 8401135 | Birmingham | Alabama | 35233 | — |
| North Central Neurology Associates- Site Number : 8401100 | Cullman | Alabama | 35058 | — |
| Alabama Neurology Associates- Site Number : 8400115 | Homewood | Alabama | 35209 | — |
| St. Joseph's Hospital and Medical Center- Site Number : 8401139 | Phoenix | Arizona | 85013 | — |
| Perseverance Research Center- Site Number : 8401138 | Scottsdale | Arizona | 85253 | — |
| Clinical Endpoints- Site Number : 8400050 | Scottsdale | Arizona | 85258 | — |
| The Neurology Center of Southern California - Carlsbad- Site Number : 8400023 | Carlsbad | California | 92011 | — |
| University of California Irvine - School of Medicine- Site Number : 8401143 | Irvine | California | 92697 | — |
| Multiple Sclerosis Center of California - Laguna Hills- Site Number : 8401122 | Laguna Hills | California | 92653 | — |
| Chemidox Clinical Trials- Site Number : 8401157 | Lancaster | California | 93534 | — |
| Hoag Memorial Hospital Presbyterian- Site Number : 8401031 | Newport Beach | California | 92663 | — |
| Private Practice - Dr. Regina Berkovich- Site Number : 8400005 | West Hollywood | California | 90048 | — |
| University of Colorado - Anschutz Medical Campus- Site Number : 8401001 | Aurora | Colorado | 80045 | — |
| Advanced Neurology of Colorado- Site Number : 8401148 | Fort Collins | Colorado | 80528 | — |
| Hartford Healthcare Medical Group- Site Number : 8401069 | Norwich | Connecticut | 06360 | — |
| New England Institute for Clinical Research- Site Number : 8400114 | Stamford | Connecticut | 06905 | — |
| MedStar Georgetown University Hospital- Site Number : 8400044 | Washington D.C. | District of Columbia | 20007 | — |
| Neurology of Central Florida- Site Number : 8401147 | Altamonte Springs | Florida | 32714 | — |
| Neurology Offices of South Florida - Boca Raton- Site Number : 8401169 | Boca Raton | Florida | 33428 | — |
| First Choice Neurology - Espinosa Neuroscience Institute- Site Number : 8401071 | Boca Raton | Florida | 33486 | — |
| Nova Clinical Research - Bradenton- Site Number : 8400189 | Bradenton | Florida | 34209 | — |
| Mayo Clinic in Florida- Site Number : 8401093 | Jacksonville | Florida | 32224 | — |
| Neurology Associates - Maitland- Site Number : 8400010 | Maitland | Florida | 32751 | — |
| University of Miami Hospital- Site Number : 8401177 | Miami | Florida | 33136 | — |
| Design Neuroscience Center- Site Number : 8401191 | Miami Lakes | Florida | 33016 | — |
| Orlando Health Neuroscience Institute - Downtown Pavilion- Site Number : 8400060 | Orlando | Florida | 32806 | — |
| Axiom Clinical Research of Florida- Site Number : 8400049 | Tampa | Florida | 33609 | — |
| University of South Florida- Site Number : 8400013 | Tampa | Florida | 33612 | — |
| Palm Beach Neurology- Site Number : 8401105 | West Palm Beach | Florida | 33407 | — |
| Velocity Clinical Research - Savannah Neurology- Site Number : 8400061 | Savannah | Georgia | 31406 | — |
| Joi Life Wellness Group LLC- Site Number : 8401192 | Smyrna | Georgia | 30080 | — |
| NorthShore Medical Group - Evanston ( Endeavor Health)- Site Number : 8401111 | Evanston | Illinois | 60201 | — |
| Consultants in Neurology- Site Number : 8401020 | Northbrook | Illinois | 60062 | — |
| Springfield Clinic 1st - 900 Building- Site Number : 8400043 | Springfield | Illinois | 62702 | — |
| IU Health Physicians - Fort Wayne - Hope Drive- Site Number : 8400058 | Fort Wayne | Indiana | 46815 | — |
| Neuroscience Institute Center- Site Number : 8400053 | Merrillville | Indiana | 46410 | — |
| University of Iowa- Site Number : 8400029 | Iowa City | Iowa | 52242 | — |
| University of Kansas Medical Center- Site Number : 8400084 | Kansas City | Kansas | 66160 | — |
| Kc Research Center- Site Number : 8400032 | Roeland Park | Kansas | 66205 | — |
| Baptist Health Lexington- Site Number : 8401149 | Lexington | Kentucky | 40503 | — |
| Norton Neurology Services- Site Number : 8401103 | Louisville | Kentucky | 40207 | — |
| NeuroMedical Clinic of Central Louisiana- Site Number : 8401159 | Alexandria | Louisiana | 71301 | — |
| The NeuroMedical Center- Site Number : 8401182 | Baton Rouge | Louisiana | 70810 | — |
| Ochsner Medical Center - Jefferson Highway- Site Number : 8400027 | New Orleans | Louisiana | 70121 | — |
| International Neurorehabilitation Institute- Site Number : 8400089 | Lutherville | Maryland | 21093 | — |
| Boston Clinical Trials- Site Number : 8401178 | Boston | Massachusetts | 02131 | — |
| Beth Israel Deaconess Medical Center - Boston- Site Number : 8401041 | Boston | Massachusetts | 02215 | — |
| Neurology Center of New England- Site Number : 8401164 | Foxborough | Massachusetts | 02035 | — |
| Henry Ford Hospital- Site Number : 8401091 | Detroit | Michigan | 48202 | — |
| Michigan Institute for Neurological Disorders- Site Number : 8400004 | Farmington Hills | Michigan | 48334 | — |
| Memorial Healthcare Institute for Neuroscience- Site Number : 8400123 | Owosso | Michigan | 48867 | — |
| Rochester Medical Group- Site Number : 8401172 | Rochester Hills | Michigan | 48307 | — |
| M Health Fairview University of Minnesota Medical Center - East Bank- Site Number : 8400056 | Minneapolis | Minnesota | 55455 | — |
| Minnesota Center for Multiple Sclerosis- Site Number : 8400073 | Plymouth | Minnesota | 55446 | — |
| Sharlin Health and Neurology- Site Number : 8400016 | Ozark | Missouri | 65721 | — |
| Washington University- Site Number : 8400076 | St Louis | Missouri | 63110 | — |
| The MS Center for Innovations in Care- Site Number : 8401141 | St Louis | Missouri | 63131 | — |
| Cleveland Clinic Lou Ruvo Center for Brain Health Las Vegas- Site Number : 8400045 | Las Vegas | Nevada | 89106 | — |
| Renown Regional Medical Center- Site Number : 8400066 | Reno | Nevada | 89502 | — |
| Rutgers University- Site Number : 8401067 | New Brunswick | New Jersey | 08903 | — |
| The University of New Mexico- Site Number : 8401090 | Albuquerque | New Mexico | 87106 | — |
| South Shore Neurologic Associates - Patchogue- Site Number : 8400063 | Patchogue | New York | 11772 | — |
| Montefiore Medical Center - Einstein Campus- Site Number : 8401145 | The Bronx | New York | 10461 | — |
| The Neurological Institute- Site Number : 8401166 | Charlotte | North Carolina | 28204 | — |
| Piedmont HealthCare - Lake Norman Neurology- Site Number : 8400002 | Charlotte | North Carolina | 28210 | — |
| Raleigh Neurology Associates- Site Number : 8400014 | Raleigh | North Carolina | 27607 | — |
| Atrium Health - Wake Forest Baptist - Shepherd- Site Number : 8400040 | Winston-Salem | North Carolina | 27103 | — |
| Sanford Brain And Spine Center- Site Number : 8401085 | Fargo | North Dakota | 58103 | — |
| Dayton Center for Neurological Disorders- Site Number : 8400079 | Centerville | Ohio | 45459 | — |
| University of Cincinnati Medical Center- Site Number : 8401117 | Cincinnati | Ohio | 45219 | — |
| The Ohio State University- Site Number : 8401009 | Columbus | Ohio | 43210 | — |
| OhioHealth Riverside Methodist Hospital- Site Number : 8401092 | Columbus | Ohio | 43214 | — |
| The Boster Center for Multiple Sclerosis- Site Number : 8400006 | Columbus | Ohio | 43235 | — |
| UC Health - Elizabeth Place- Site Number : 8401008 | Dayton | Ohio | 45408 | — |
| Oklahoma Medical Research Foundation- Site Number : 8400039 | Oklahoma City | Oklahoma | 73104 | — |
| Providence St. Vincent's Medical Center- Site Number : 8400052 | Portland | Oregon | 97225 | — |
| Oregon Neurology Associates- Site Number : 8400188 | Springfield | Oregon | 97477 | — |
| Abington Neurological Associates- Site Number : 8401065 | Abington | Pennsylvania | 19001 | — |
| Penn State Health Milton South Hershey Medical Center- Site Number : 8401176 | Hershey | Pennsylvania | 17033 | — |
| Thomas Jefferson University Hospital- Site Number : 8400035 | Philadelphia | Pennsylvania | 19107 | — |
| Allegheny General Hospital- Site Number : 8401173 | Pittsburgh | Pennsylvania | 15212 | — |
| UPMC Magee-Womens Hospital- Site Number : 8401133 | Pittsburgh | Pennsylvania | 15213 | — |
| Premier Neurology- Site Number : 8401047 | Greer | South Carolina | 29650 | — |
| Hope Neurology- Site Number : 8400019 | Knoxville | Tennessee | 37922 | — |
| Neurology Consultants of Dallas - Lyndon B Johnson Freeway- Site Number : 8400152 | Dallas | Texas | 75243 | — |
| ANESC Research- Site Number : 8400187 | El Paso | Texas | 79912 | — |
| Baylor College of Medicine Medical Center- Site Number : 8401170 | Houston | Texas | 77030 | — |
| North Texas Institute of Neurology & Headache - Plano- Site Number : 8401083 | Plano | Texas | 75024 | — |
| UT Health - San Antonio- Site Number : 8401167 | San Antonio | Texas | 78229 | — |
| Neurology Center of San Antonio- Site Number : 8400099 | San Antonio | Texas | 78258 | — |
| Texas Institute for Neurological Disorders - Sherman- Site Number : 8400018 | Sherman | Texas | 75092 | — |
| Inova Schar Cancer Institute - Fairfax - Innovation Park Drive- Site Number : 8401109 | Fairfax | Virginia | 22031 | — |
| Multiple Sclerosis Center of Greater Washington (MSCGW)- Site Number : 8401128 | Vienna | Virginia | 22182 | — |
| Sentara Family Medicine Physicians - Virginia Beach - Glenn Mitchell Drive- Site Number : 8401168 | Virginia Beach | Virginia | 23456 | — |
| Swedish Medical Center - Seattle- Site Number : 8400078 | Seattle | Washington | 98104 | — |
| University of Washington Medical Center - Northwest- Site Number : 8401146 | Seattle | Washington | 98133 | — |
| MultiCare Tacoma General Hospital- Site Number : 8401140 | Tacoma | Washington | 98405 | — |
| Wheaton Franciscan Healthcare - St Francis- Site Number : 8400034 | Milwaukee | Wisconsin | 53215 | — |
| Medical College of Wisconsin - Milwaukee Campus- Site Number : 8400038 | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 283 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06141473, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 13, 2026 · Synced May 17, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06141473 live on ClinicalTrials.gov.