A Proof of Concept and Dose-finding Study of XXB750 in Patients With Heart Failure
Public ClinicalTrials.gov record NCT06142383. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multi-center, Randomized, Placebo- and Active-controlled, Parallel-group, 24-week Proof of Concept and Dose-finding Study to Evaluate Efficacy, Safety, and Tolerability of XXB750 in Patients With Heart Failure
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This was a multicenter, randomized, placebo- and active-controlled, parallel-group, 24-week trial to investigate the efficacy, safety, and tolerability of XXB750 in participants with HFrEF/HFmrEF.
Study identification
- NCT ID
- NCT06142383
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 136 participants
Conditions and interventions
Conditions
Interventions
- Placebo Biological
- XXB750 Low dose Biological
- XXB750 Medium Dose Biological
- XXB750 High Dose Biological
- Sacubitril/valsartan Drug
Biological · Drug
Eligibility (public fields only)
- Age range
- 18 Years to 100 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 12, 2023 (Actual)
- Primary completion
- Nov 1, 2024 (Actual)
- Completion
- Nov 1, 2024 (Actual)
- Last update posted
- Jan 27, 2026
2023 – 2024
United States locations
- U.S. sites
- 14
- U.S. states
- 10
- U.S. cities
- 14
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| SEC Clinical Research | Dothan | Alabama | 36305 | — |
| Heart Center Research Llc | Huntsville | Alabama | 35801 | — |
| Nature Coast Clinical Research LLC | Inverness | Florida | 34452 | — |
| Inpatient Research Clinical LLC | Miami Lakes | Florida | 33014 | — |
| Cardiology Partners Clinical Research Institute | Wellington | Florida | 33449 | — |
| American Clinical Trials | Acworth | Georgia | 30101 | — |
| The Research Group | Lexington | Kentucky | 40503 | — |
| Heart Clinic of Hammond | Hammond | Louisiana | 70403 | — |
| Anderson Medical Research | Ft. Washington | Maryland | 20744 | — |
| Revival Research Institute | Troy | Michigan | 48084 | — |
| Aultman Hospital | Canton | Ohio | 44710 | — |
| NexGen Research | Lima | Ohio | 45801 | — |
| Tennessee Center For Clinical Trials | Tullahoma | Tennessee | 37388 | — |
| Dominion Medical Associates | Richmond | Virginia | 23219 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 48 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06142383, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 27, 2026 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06142383 live on ClinicalTrials.gov.