Nafamostat Efficacy in Phase 3 Registrational CRRT Study

ClinicalTrials.gov ID: NCT06150742

Public ClinicalTrials.gov record NCT06150742. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jul 23, 2026, 4:58 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, Placebo-controlled, Double-blind, Multi-center Study of the Safety and Efficacy of Niyad in Patients Undergoing Continuous Renal Replacement Therapy (CRRT) Who Cannot Tolerate Heparin or Are at a Higher Risk for Bleeding

Study identification

NCT ID: NCT06150742
Recruitment status: Recruiting
Study type: Interventional
Phase: Not applicable
Lead sponsor: Talphera, Inc; Industry
Enrollment: 70 participants

Conditions and interventions

Conditions

Acute Kidney Injury

Interventions

Niyad (nafamostat mesylate) Device
Placebo (0.9% NaCl) Device

Device

Eligibility (public fields only)

Age range: 18 Years to 80 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Aug 14, 2024
Primary completion: Nov 30, 2025
Completion: Nov 30, 2025
Last update posted: Oct 14, 2025

2024 – 2025

United States locations

U.S. sites: 10
U.S. states: 9
U.S. cities: 10

Facility	City	State	ZIP	Site status
University of California Los Angeles	Los Angeles	California	90095	Recruiting
AdventHealth	Orlando	Florida	32804	Not yet recruiting
Henry Ford Health	Detroit	Michigan	48202	Recruiting
University of New Mexico	Albuquerque	New Mexico	87131	Recruiting
Northwell Health	Great Neck	New York	11021	Recruiting
Mount Sinai	New York	New York	10029	Recruiting
Cincinnati Children's Hospital Medical Center	Cincinnati	Ohio	45229	Recruiting
University of Pittsburgh Medical Center	Pittsburgh	Pennsylvania	15213	Recruiting
Medical University of South Carolina	Charleston	South Carolina	29425	Recruiting
Baylor University Medical Center	Dallas	Texas	75246	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06150742, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Oct 14, 2025 · Synced Jul 23, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06150742 live on ClinicalTrials.gov.

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