Efficacy and Safety of Lorundrostat in Addition to Sodium-Glucose Cotransporter-2 Inhibitors (SGLT2i) in Subjects With Hypertension and Chronic Kidney Disease (CKD) With Albuminuria
Public ClinicalTrials.gov record NCT06150924. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Crossover, Double Blind, Placebo Controlled, Phase 2 Study to Evaluate the Efficacy and Safety of Lorundrostat in Addition to Sodium-Glucose Cotransporter-2 Inhibitors, in Adults With Hypertension and Chronic Kidney Disease With Albuminuria
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a randomized, double-blind (DB), placebo controlled, crossover study with a two-period, two-sequence (2x2) design evaluating the efficacy and safety of 25 mg QD lorundrostat (an aldosterone synthase inhibitor \[ASI\]) in addition to a SGLT2i for the treatment of hypertension in subjects with CKD and albuminuria while receiving stable treatment with an Angiotensin-converting enzyme inhibitor (ACEi) or an Angiotensin receptor blocker (ARB). Subjects will be at least 18 years old with hypertension, and mild to severe CKD with albuminuria at the Screening Visit.
Study identification
- NCT ID
- NCT06150924
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 60 participants
Conditions and interventions
Conditions
Interventions
- Lorundrostat 25mg+SGLT2i QD, Washout, Placebo+SGLT2i QD Drug
- Placebo QD + SGLT2i QD, Washout, Lorundrostat 25mg+SGLT2i QD Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 14, 2023 (Actual)
- Primary completion
- Feb 27, 2025 (Actual)
- Completion
- Apr 23, 2025 (Actual)
- Last update posted
- Jun 3, 2026
2023 – 2025
United States locations
- U.S. sites
- 44
- U.S. states
- 19
- U.S. cities
- 42
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Kidney Disease & Hypertension Centers (AKDHC) - Thunderbird Office | Glendale | Arizona | 85306 | — |
| Arizona Kidney Disease & Hypertension Centers (AKDHC) - Thomas Office | Phoenix | Arizona | 85016 | — |
| Balboa Nephrology Medical Group, Inc. (BNMG) - California Institute of Renal Research (CIRR) - Chula Vista | Chula Vista | California | 91910 | — |
| Balboa Nephrology Medical Group, Inc. (BNMG) - El Centro | El Centro | California | 92243 | — |
| Amicis Research Center - Granada Hills | Granada Hills | California | 91344 | — |
| Balboa Nephrology Medical Group, Inc. (Bnmg) - La Mesa | La Mesa | California | 91942-3059 | — |
| Academic Medical Research Institute (AMRI) - Los Angeles | Los Angeles | California | 90022 | — |
| Amicis Research Center | Northridge | California | 91324 | — |
| Amicis Research Center - Vacaville | Vacaville | California | 95687-3560 | — |
| Colorado Kidney Care (Denver Nephrology) - Denver Office | Denver | Colorado | 80218-1216 | — |
| Qway Research | Coconut Grove | Florida | 33133 | — |
| Indago Research and Health Center | Hialeah | Florida | 33012 | — |
| Elixia Pines, LLC | Hollywood | Florida | 33024 | — |
| Elixia Central Florida, LLC | Orlando | Florida | 32806 | — |
| Infigo Clinical Research, Llc | Sanford | Florida | 32771 | — |
| Genesis Clinical Research - Tampa | Tampa | Florida | 33614 | — |
| Palm Beach Diabetes and Endocrine Specialists, PA (PBDES) - West Palm Beach Office | West Palm Beach | Florida | 33401 | — |
| American Clinical Trials Llc | Acworth | Georgia | 30101 | — |
| Nephrology of the Golden Isles - Brunswick | Brunswick | Georgia | 31520 | — |
| ClinCept, LLC | Columbus | Georgia | 32896 | — |
| Georgia Nephrology, Llc | Lawrenceville | Georgia | 30046-8761 | — |
| Nephrology Associates of Kentuckiana, PSC (NAK) | Louisville | Kentucky | 40205 | — |
| Lcms Health University Medical Center New Orleans | New Orleans | Louisiana | 70112-3018 | — |
| Northwest Louisiana Nephrology, Llc - Shreveport | Shreveport | Louisiana | 71101 | — |
| Tufts University School of Medicine (Tusm) - Tufts Medical Center (Tmc) (Tufts-New England Medical Center) | Boston | Massachusetts | 02111 | — |
| Elixia MKC, LLC | Pontiac | Michigan | 48341 | — |
| Kansas City Kidney Consultants (Arms, Dodge, Robinson, Wilber & Crouch, Inc.) - Kansas City | Kansas City | Missouri | 64111 | — |
| Seacoast Kidney & Hypertension Specialists - Portsmouth Office | Portsmouth | New Hampshire | 03801 | — |
| Suny Downstate Medical Center - Parkside Dialysis Center | Brooklyn | New York | 11226-1508 | — |
| Nephrology Associates, PC | Fresh Meadows | New York | 11365 | — |
| Nephrology Associates | Fresh Meadows | New York | 11365 | — |
| Triad Internal Medicine | Asheboro | North Carolina | 27205 | — |
| Nephrology Associates, Pllc - Winston-Salem | Winston-Salem | North Carolina | 27103 | — |
| Nephrology Consultants - Oklahoma City | Oklahoma City | Oklahoma | 73116-1516 | — |
| Columbia Nephrology | Columbia | South Carolina | 29203 | — |
| Southeast Renal Research Institute | Chattanooga | Tennessee | 37408 | — |
| Dallas Nephrology Associates (Dna) - Renal Disease Research Institute (Rdri) | Dallas | Texas | 75235 | — |
| Liberty Research Center | Dallas | Texas | 75237 | — |
| R&H Clinical Research | Katy | Texas | 27205 | — |
| E T Nephrology Associates - Lufkin | Lufkin | Texas | 75904 | — |
| Prx Research | Mesquite | Texas | 75149 | — |
| Gamma Medical Research, Inc | Mission | Texas | 78572 | — |
| Chrysalis Clinical Research (CCR) | St. George | Utah | 84790 | — |
| Mendez Center for Clinical Research, LLC | Woodbridge | Virginia | 22191 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06150924, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 3, 2026 · Synced Oct 20, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06150924 live on ClinicalTrials.gov.