Safety, Tolerability, and Immunogenicity Study of a 31-Valent Pneumococcal Conjugate Vaccine (VAX-31) in Adults
Public ClinicalTrials.gov record NCT06151288. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1/2, Randomized, Observer-Blind, Dose-Finding, Active-Controlled, Parallel-Group, Clinical Study to Evaluate the Safety, Tolerability, and Immunogenicity of a 31-Valent Pneumococcal Conjugate Vaccine (VAX-31) in Healthy Adults Aged 50 Years and Older
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The objective of the study is to evaluate the safety, tolerability and immunogenicity of a single injection of VAX-31 at 3 dose levels compared to Prevnar 20™ (PCV20) in adults 50 to 64 years of age in Stage 1. Stage 2 will evaluate the safety, tolerability, and immunogenicity of a single injection of VAX-31 at 3 dose levels compared to PCV20 in adults aged 50 years and older.
Study identification
- NCT ID
- NCT06151288
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 1,015 participants
Conditions and interventions
Conditions
Interventions
- 31 valent pneumococcal conjugate vaccine Biological
- 20 valent pneumococcal conjugate vaccine Biological
Biological
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 8, 2023 (Actual)
- Primary completion
- Jul 17, 2024 (Actual)
- Completion
- Jul 17, 2024 (Actual)
- Last update posted
- Jul 28, 2025
2023 – 2024
United States locations
- U.S. sites
- 25
- U.S. states
- 19
- U.S. cities
- 25
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| AMR Mobile | Mobile | Alabama | 36608 | — |
| AMR Phoenix | Phoenix | Arizona | 85282 | — |
| Research Centers of America | Hollywood | Florida | 33024 | — |
| Health Awareness | Jupiter | Florida | 33458 | — |
| Optimal Research | Melbourne | Florida | 32934 | — |
| Precision Clinical Research | Sunrise | Florida | 33351 | — |
| Velocity Clinical Research, Savannah | Savannah | Georgia | 31406 | — |
| Healthcare Research Network II, LLC | Flossmoor | Illinois | 60422 | — |
| Johnson County Clin-Trials | Lenexa | Kansas | 66219 | — |
| DM Clinical Research - Detroit | Detroit | Michigan | 48076 | — |
| Velocity Clinical Research Omaha | Omaha | Nebraska | 68134 | — |
| WR-CRCN | Las Vegas | Nevada | 89106 | — |
| Cenexel AMRI | Toms River | New Jersey | 08755 | — |
| Rochester Clinical Research | Rochester | New York | 14609 | — |
| CTI Clinical Research Center | Cincinnati | Ohio | 45212 | — |
| Velocity Clinical Research, Cleveland | Cleveland | Ohio | 44122 | — |
| DM Clinical Research - Philadelphia | Philadelphia | Pennsylvania | 19107 | — |
| Velocity Clinical Research | Warwick | Rhode Island | 02886 | — |
| Coastal Carolina Research | North Charleston | South Carolina | 29405 | — |
| AMR Knoxville | Knoxville | Tennessee | 37909 | — |
| Benchmark Research | Fort Worth | Texas | 76135 | — |
| Benchmark Research | San Angelo | Texas | 76904 | — |
| CenExel JBR Clinical Research | Salt Lake City | Utah | 84107 | — |
| Charlottesville Medical Research | Charlottesville | Virginia | 22911 | — |
| Health Research of Hampton Roads | Newport News | Virginia | 23606 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06151288, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 28, 2025 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06151288 live on ClinicalTrials.gov.