Study of the Research Medicine CIN-103 in Adults With Irritable Bowel Syndrome With Predominant Diarrhea (IBS-D).
Public ClinicalTrials.gov record NCT06153420. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Parallel-Group Study to Evaluate the Efficacy, Safety, and Tolerability of CIN-103 in Adults With Irritable Bowel Syndrome With Predominant Diarrhea (IBS-D)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The goal of this clinical trial is to evaluate if the study drug, CIN-103, can help reduce the symptoms associated with irritable bowel syndrome with predominant diarrhea (IBS-D) in adult patients. The main questions it aims to answer are: * To evaluate the efficacy of CIN-103 on symptoms of IBS-D when given to patients with IBS-D compared to a placebo. * To evaluate the safety and tolerability of CIN-103 when given to patients with IBS-D compared to a placebo Participants will attend the following visits: * Screening Period (1 Visit) * Baseline Period (1 Visit) * Will complete daily diary and other Patient Reported Outcomes (PROs) as described in the protocol to assess eligibility for continued participation. * 12-Week Treatment Period (5 Visits) * Study drug taken twice daily by mouth. * Will complete daily diaries and other PROs as described in the protocol. * Follow- Up Period (1 Visit) Researchers will compare CIN-103 Dose 1, CIN-103 Dose 2, and placebo, to evaluate the clinical response to multiple dose strengths of CIN-103 relative to placebo on abdominal pain and stool consistency along with safety and tolerability.
Study identification
- NCT ID
- NCT06153420
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 421 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 28, 2023 (Actual)
- Primary completion
- Jul 28, 2025 (Actual)
- Completion
- Jul 28, 2025 (Actual)
- Last update posted
- Dec 15, 2025
2023 – 2025
United States locations
- U.S. sites
- 53
- U.S. states
- 24
- U.S. cities
- 48
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Digestive Health Specialists - Dothan | Dothan | Alabama | 36305 | — |
| Clinical Research Associates, LLC | Huntsville | Alabama | 35801 | — |
| Elite Clinical Studies LLC | Phoenix | Arizona | 85018 | — |
| GI Alliance - Sun City | Sun City | Arizona | 85351 | — |
| Applied Research Center of Arkansas | Little Rock | Arkansas | 72212 | — |
| Paragon Rx Clinical, Inc. - Garden Grove | Garden Grove | California | 92840 | — |
| Gastro Care Institute- lancaster | Lancaster | California | 93534 | — |
| Medical Associates Research Group | San Diego | California | 92123 | — |
| American Family Research Group | Cape Coral | Florida | 33909 | — |
| USA and International Research Inc. | Doral | Florida | 33126 | — |
| International Research Associates LLC | Miami | Florida | 33183 | — |
| Innovation Medical Research Center | Palmetto Bay | Florida | 33157 | — |
| Velocity Clinical Research,, Savannah | Savannah | Georgia | 31406 | — |
| Southwest Gastroenterology | Oak Lawn | Illinois | 60453 | — |
| DelRicht Research | Mandeville | Louisiana | 70471 | — |
| Tandem Clinical Research GI LLC | Marrero | Louisiana | 70072 | — |
| Tandem Clinical Research GI LLC | Metairie | Louisiana | 70006 | — |
| DelRicht Research | New Orleans | Louisiana | 70115 | — |
| Delta Research Partners, LLC | West Monroe | Louisiana | 71291 | — |
| DelRicht Research of Bethesda Clinical Trials | Rockville | Maryland | 20852 | — |
| St. Charles Clinical Research | Weldon Spring | Missouri | 63304 | — |
| Quality Clinical Research, Inc | Omaha | Nebraska | 68114 | — |
| Las Vegas Medical Research | Las Vegas | Nevada | 89113 | — |
| Digestive Disease Specialists | Las Vegas | Nevada | 89128 | — |
| Advanced Research Institute - Reno | Reno | Nevada | 89511 | — |
| Allied Digestive Health Clinical Research Organization | Somers Point | New Jersey | 08244 | — |
| Allied Digestive Health-Jersey Shore Gastroenterology - Point Commons | Somers Point | New Jersey | 08244 | — |
| Albuquerque Clinical Trials, Inc | Albuquerque | New Mexico | 87102 | — |
| Westchester Putnam Gastro | Carmel Hamlet | New York | 10512 | — |
| IMA Clinical Research PC and Affiliates- New York, NY | New York | New York | 10128 | — |
| NY Scientific | New York | New York | 11235 | — |
| Atrium Health - Center for Gastroenterology and Hepatology MMP | Charlotte | North Carolina | 28204 | — |
| Peters Medical Research | High Point | North Carolina | 27262 | — |
| IMA Clinical Research | Mount Airy | North Carolina | 27030 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Remington Davis, Inc. | Columbus | Ohio | 43215 | — |
| Great Lakes Gastroenterology Research LLC | Mentor | Ohio | 44060 | — |
| Northshore Gastroenterology Research, LLC | Westlake | Ohio | 44145 | — |
| Options Health Research LLC | Tulsa | Oklahoma | 74104 | — |
| Susquehanna Research Group, LLC | Harrisburg | Pennsylvania | 17110 | — |
| DelRicht Research of Charleston Clinical Trials | Charleston | South Carolina | 29407 | — |
| Palmetto Clinical Research | Summerville | South Carolina | 29485 | — |
| Galen Medical Group - Downtown Gastroenterology Location | Chattanooga | Tennessee | 37404 | — |
| Tri-Cities Gastroenterology | Kingsport | Tennessee | 37663 | — |
| Advanced Gastroenterology | Union City | Tennessee | 38261 | — |
| The University of Texas Health Science Center at Houston | Bellaire | Texas | 77401 | — |
| The Clinical Trials Network LLC | Houston | Texas | 77074 | — |
| Care and Cure Clinic | Houston | Texas | 77090 | — |
| GLRI - McAllen Research | Pharr | Texas | 78577 | — |
| Quality Research Inc | San Antonio | Texas | 78209 | — |
| Gastroenterology Research of San Antonio | San Antonio | Texas | 78229 | — |
| Advanced Research Institute | Ogden | Utah | 84405 | — |
| GI Alliance - Washington Gastroenterology | Tacoma | Washington | 98405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06153420, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 15, 2025 · Synced Oct 24, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06153420 live on ClinicalTrials.gov.