A Phase 1/2 Study of VX-670 in Adult Participants With Myotonic Dystrophy 1 (DM1)

ClinicalTrials.gov ID: NCT06185764

Public ClinicalTrials.gov record NCT06185764. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jul 21, 2026, 6:06 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 1/2, Randomized, Double-blind, Placebo-controlled Single- and Multiple-dose Escalation Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of VX-670 in Adult Subjects With Myotonic Dystrophy Type 1

Study identification

NCT ID: NCT06185764
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: Vertex Pharmaceuticals Incorporated; Industry
Enrollment: 52 participants

Conditions and interventions

Conditions

Myotonic Dystrophy Type 1 (DM1)

Interventions

VX-670 Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 64 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Feb 19, 2024
Primary completion: Feb 1, 2027
Completion: Feb 1, 2027
Last update posted: Jun 7, 2026

2024 – 2027

United States locations

U.S. sites: 8
U.S. states: 8
U.S. cities: 8

Facility	City	State	ZIP	Site status
Stanford Neuromuscular Research	San Carlos	California	94070	Recruiting
University of Florida Clinical Research Center	Gainesville	Florida	32608	Recruiting
University of Kansas Medical Center	Fairway	Kansas	66205	Recruiting
Boston Children's Hospital	Boston	Massachusetts	02115	Recruiting
Washington University School of Medicine / St. Louis Children's Hospital	St Louis	Missouri	63110	Recruiting
Wake Forest Baptist Health	Winston-Salem	North Carolina	27104	Recruiting
University of Pennsylvania	Philadelphia	Pennsylvania	19104	Recruiting
Virginia Commonwealth University (Sanger Hall)	Richmond	Virginia	23298	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 18 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06185764, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jun 7, 2026 · Synced Jul 21, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06185764 live on ClinicalTrials.gov.

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