Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer

ClinicalTrials.gov ID: NCT06205485

Public ClinicalTrials.gov record NCT06205485. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 6, 2026, 8:54 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3 Randomized Trial Of Neoadjuvant Chemotherapy, Excision And Observation Versus Chemoradiotherapy For Early Rectal Cancer

Study identification

NCT ID: NCT06205485
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Canadian Cancer Trials Group; Network
Enrollment: 250 participants

Conditions and interventions

Conditions

Rectal Cancer

Interventions

Capecitabine Drug
Fluoruracil Drug
Leucovorin Drug
Oxaliplatin Drug
Radiation Radiation

Drug · Radiation

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 25, 2024
Primary completion: Jan 29, 2030
Completion: Jun 29, 2030
Last update posted: Apr 13, 2026

2024 – 2030

United States locations

U.S. sites: 99
U.S. states: 28
U.S. cities: 84

Facility	City	State	ZIP	Site status
Cancer Center at Saint Joseph's	Phoenix	Arizona	85004	Recruiting
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care	Irvine	California	92612	Recruiting
Los Angeles General Medical Center	Los Angeles	California	90033	Recruiting
USC / Norris Comprehensive Cancer Center	Los Angeles	California	90033	Recruiting
UC Irvine Health/Chao Family Comprehensive Cancer Center	Orange	California	92868	Recruiting
Beebe South Coastal Health Campus	Millville	Delaware	19967	Recruiting
Helen F Graham Cancer Center	Newark	Delaware	19713	Recruiting
Medical Oncology Hematology Consultants PA	Newark	Delaware	19713	Recruiting
Beebe Health Campus	Rehoboth Beach	Delaware	19971	Recruiting
Orlando Health Cancer Institute	Orlando	Florida	32806	Recruiting
Emory University Hospital Midtown	Atlanta	Georgia	30308	Recruiting
Emory University Hospital/Winship Cancer Institute	Atlanta	Georgia	30322	Recruiting
Emory Saint Joseph's Hospital	Atlanta	Georgia	30342	Recruiting
Rush-Copley Medical Center	Aurora	Illinois	60504	Recruiting
Northwestern University	Chicago	Illinois	60611	Recruiting
Carle at The Riverfront	Danville	Illinois	61832	Recruiting
Northwestern Medicine Cancer Center Kishwaukee	DeKalb	Illinois	60115	Recruiting
Carle Physician Group-Effingham	Effingham	Illinois	62401	Recruiting
Northwestern Medicine Cancer Center Delnor	Geneva	Illinois	60134	Recruiting
Carle Physician Group-Mattoon/Charleston	Mattoon	Illinois	61938	Recruiting
Carle Cancer Center	Urbana	Illinois	61801	Recruiting
Northwestern Medicine Cancer Center Warrenville	Warrenville	Illinois	60555	Recruiting
Northwest Cancer Center - Main Campus	Crown Point	Indiana	46307	Recruiting
Northwest Oncology LLC	Dyer	Indiana	46311	Recruiting
Northwest Cancer Center - Hobart	Hobart	Indiana	46342	Recruiting
Saint Mary Medical Center	Hobart	Indiana	46342	Recruiting
The Community Hospital	Munster	Indiana	46321	Recruiting
Northwest Cancer Center - Valparaiso	Valparaiso	Indiana	46383	Recruiting
University Medical Center New Orleans	New Orleans	Louisiana	70112	Recruiting
Beverly Hospital	Beverly	Massachusetts	01915	Recruiting
Lahey Hospital and Medical Center	Burlington	Massachusetts	01805	Recruiting
Addison Gilbert Hospital	Gloucester	Massachusetts	01930	Recruiting
Henry Ford Cancer Institute-Downriver	Brownstown	Michigan	48183	Recruiting
Henry Ford Macomb Hospital-Clinton Township	Clinton Township	Michigan	48038	Recruiting
Henry Ford Medical Center-Fairlane	Dearborn	Michigan	48126	Recruiting
Henry Ford Hospital	Detroit	Michigan	48202	Recruiting
Corewell Health Grand Rapids Hospitals - Butterworth Hospital	Grand Rapids	Michigan	49503	Recruiting
Allegiance Health	Jackson	Michigan	49201	Recruiting
West Michigan Cancer Center	Kalamazoo	Michigan	49007	Recruiting
Henry Ford Medical Center-Columbus	Novi	Michigan	48377	Recruiting
Henry Ford West Bloomfield Hospital	West Bloomfield	Michigan	48322	Recruiting
Henry Ford Wyandotte Hospital	Wyandotte	Michigan	48192	Recruiting
Sanford Joe Lueken Cancer Center	Bemidji	Minnesota	56601	Recruiting
Mercy Hospital Saint Louis	St Louis	Missouri	63141	Recruiting
Renown Regional Medical Center	Reno	Nevada	89502	Recruiting
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center	Lebanon	New Hampshire	03756	Recruiting
Memorial Sloan Kettering Basking Ridge	Basking Ridge	New Jersey	07920	Recruiting
Memorial Sloan Kettering Monmouth	Middletown	New Jersey	07748	Recruiting
Memorial Sloan Kettering Bergen	Montvale	New Jersey	07645	Recruiting
University of New Mexico Cancer Center	Albuquerque	New Mexico	87106	Recruiting
Roswell Park Cancer Institute	Buffalo	New York	14263	Recruiting
Memorial Sloan Kettering Commack	Commack	New York	11725	Recruiting
Memorial Sloan Kettering Westchester	Harrison	New York	10604	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
University of Rochester	Rochester	New York	14642	Recruiting
Memorial Sloan Kettering Nassau	Uniondale	New York	11553	Recruiting
Wilmot Cancer Institute at Webster	Webster	New York	14580	Recruiting
East Carolina University	Greenville	North Carolina	27834	Recruiting
Sanford Bismarck Medical Center	Bismarck	North Dakota	58501	Recruiting
Sanford Broadway Medical Center	Fargo	North Dakota	58122	Recruiting
Sanford Roger Maris Cancer Center	Fargo	North Dakota	58122	Recruiting
Miami Valley Hospital South	Centerville	Ohio	45459	Recruiting
University of Cincinnati Cancer Center-UC Medical Center	Cincinnati	Ohio	45219	Recruiting
Miami Valley Hospital	Dayton	Ohio	45409	Suspended
Premier Blood and Cancer Center	Dayton	Ohio	45409	Recruiting
Miami Valley Hospital North	Dayton	Ohio	45415	Recruiting
Atrium Medical Center-Middletown Regional Hospital	Franklin	Ohio	45005-1066	Recruiting
Miami Valley Cancer Care and Infusion	Greenville	Ohio	45331	Recruiting
Upper Valley Medical Center	Troy	Ohio	45373	Recruiting
University of Cincinnati Cancer Center-West Chester	West Chester	Ohio	45069	Recruiting
Clackamas Radiation Oncology Center	Clackamas	Oregon	97015	Recruiting
Legacy Mount Hood Medical Center	Gresham	Oregon	97030	Recruiting
Providence Newberg Medical Center	Newberg	Oregon	97132	Recruiting
Providence Willamette Falls Medical Center	Oregon City	Oregon	97045	Recruiting
Legacy Good Samaritan Hospital and Medical Center	Portland	Oregon	97210	Recruiting
Providence Portland Medical Center	Portland	Oregon	97213	Recruiting
Providence Saint Vincent Medical Center	Portland	Oregon	97225	Recruiting
Oregon Health and Science University	Portland	Oregon	97239	Recruiting
Legacy Meridian Park Hospital	Tualatin	Oregon	97062	Recruiting
Christiana Care Health System-Concord Health Center	Chadds Ford	Pennsylvania	19317	Recruiting
Sanford Cancer Center Oncology Clinic	Sioux Falls	South Dakota	57104	Recruiting
Sanford USD Medical Center - Sioux Falls	Sioux Falls	South Dakota	57117-5134	Recruiting
The West Clinic - Wolf River	Germantown	Tennessee	38138	Recruiting
Vanderbilt University/Ingram Cancer Center	Nashville	Tennessee	37232	Recruiting
M D Anderson Cancer Center	Houston	Texas	77030	Recruiting
Dartmouth Cancer Center - North	Saint Johnsbury	Vermont	05819	Recruiting
FHCC Overlake	Bellevue	Washington	98004	Recruiting
FHCC at EvergreenHealth	Kirkland	Washington	98034	Recruiting
Virginia Mason Medical Center	Seattle	Washington	98101	Recruiting
Fred Hutchinson Cancer Center	Seattle	Washington	98109	Recruiting
FHCC at Northwest Hospital	Seattle	Washington	98133	Recruiting
Legacy Cancer Institute Medical Oncology and Day Treatment	Vancouver	Washington	98684	Recruiting
Legacy Salmon Creek Hospital	Vancouver	Washington	98686	Recruiting
Marshfield Medical Center-EC Cancer Center	Eau Claire	Wisconsin	54701	Recruiting
Marshfield Medical Center-Marshfield	Marshfield	Wisconsin	54449	Recruiting
Marshfield Medical Center - Minocqua	Minocqua	Wisconsin	54548	Recruiting
Marshfield Medical Center-Rice Lake	Rice Lake	Wisconsin	54868	Recruiting
Marshfield Medical Center-River Region at Stevens Point	Stevens Point	Wisconsin	54482	Recruiting
Marshfield Medical Center - Weston	Weston	Wisconsin	54476	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 6 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06205485, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 13, 2026 · Synced May 6, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06205485 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →