A Study to Assess Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Reduced Ejection Fraction (Cycle-1-REF)
Public ClinicalTrials.gov record NCT06215911. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Dose Finding Study to Assess the Safety and Effectiveness of Tovinontrine in Patients With Chronic Heart Failure With Reduced Ejection Fraction
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the safety and effectiveness of tovinontrine compared to placebo to lower NT-proBNP in patients with chronic heart failure with reduced ejection fraction.
Study identification
- NCT ID
- NCT06215911
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 557 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 13, 2024 (Actual)
- Primary completion
- Oct 10, 2025 (Actual)
- Completion
- Oct 10, 2025 (Actual)
- Last update posted
- Sep 1, 2026
2024 – 2025
United States locations
- U.S. sites
- 26
- U.S. states
- 18
- U.S. cities
- 26
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cardurion Investigative Site | Birmingham | Alabama | 35233 | — |
| Cardurion Investigative Site | Little Rock | Arkansas | 72204 | — |
| Cardurion Investigative Site | Beverly Hills | California | 90211 | — |
| Cardurion Investigative Site | Orange | California | 92868 | — |
| Cardurion Investigative Site | Torrance | California | 90502 | — |
| Cardurion Investigative Site | Van Nuys | California | 91405 | — |
| Cardurion Investigative Site | Jacksonville | Florida | 32216 | — |
| Cardurion Investigative Site | Miami | Florida | 33137 | — |
| Cardurion Investigative Site | Hazel Crest | Illinois | 60429 | — |
| Cardurion Investigative Site | Peoria | Illinois | 61636 | — |
| Cardurion Investigative Site | Alexandria | Louisiana | 71301 | — |
| Cardurion Investigative Site | Covington | Louisiana | 70433 | — |
| Cardurion Investigative Site | Baltimore | Maryland | 21201 | — |
| Cardurion Investigative Site | St Louis | Missouri | 63110 | — |
| Cardurion Investigative Site | Omaha | Nebraska | 68198 | — |
| Cardurion Investigative Site | Buffalo | New York | 14215 | — |
| Cardurion Investigative Site | New York | New York | 10025 | — |
| Cardurion Investigative Site | Cleveland | Ohio | 44195 | — |
| Cardurion Investigative Site | Oklahoma City | Oklahoma | 73135 | — |
| Cardurion Investigative Site | Rapid City | South Dakota | 57701 | — |
| Cardurion Investigative Site | Nashville | Tennessee | 37232 | — |
| Cardurion Investigative Site | Dallas | Texas | 75226 | — |
| Cardurion Investigative Site | McKinney | Texas | 75069 | — |
| Cardurion Investigative Site | Burlington | Vermont | 05401 | — |
| Cardurion Investigative Site | Seattle | Washington | 98195 | — |
| Cardurion Investigative Site | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 113 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06215911, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 1, 2026 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06215911 live on ClinicalTrials.gov.