The Effects of Psilocybin on Self-Focus and Self-Related Processing in Major Depressive Disorder

ClinicalTrials.gov ID: NCT06247839

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Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This open-label functional Magnetic Resonance Imaging (fMRI) study will assess the effects of a single dose of psilocybin on rumination and the neural correlates of rumination in individuals with major depressive disorder.

Study identification

NCT ID: NCT06247839
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Sharmin Ghaznavi; Other
Enrollment: 20 participants

Conditions and interventions

Conditions

Major Depressive Disorder

Interventions

Psilocybin Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 55 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Sep 10, 2024 (Actual)
Primary completion: Jun 30, 2028 (Estimated)
Completion: Jun 30, 2028 (Estimated)
Last update posted: Aug 13, 2026

2024 – 2028

United States locations

U.S. sites: 1
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
Athinoula A. Martinos Center for Biomedical Imaging	Charlestown	Massachusetts	02129	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06247839, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Aug 13, 2026 · Synced Nov 14, 2026