ClinicalTrials.gov record
Zilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications (KARDIA-3)
ClinicalTrials.gov ID: NCT06272487
Public ClinicalTrials.gov record NCT06272487. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Zilebesiran Used as Add-on Therapy in Adult Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications
Study identification
- NCT ID
- NCT06272487
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Alnylam Pharmaceuticals
- Industry
- Enrollment
- 375 participants
Conditions and interventions
Conditions
Interventions
- Placebo Drug
- Zilebesiran Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 28, 2024
- Primary completion
- Jun 18, 2025
- Completion
- Nov 30, 2025
- Last update posted
- Mar 1, 2026
2024 – 2025
United States locations
- U.S. sites
- 139
- U.S. states
- 38
- U.S. cities
- 118
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Clinical Trial Site | Alexander City | Alabama | 35010 | — |
| Clinical Trial Site | Daphne | Alabama | 36526 | — |
| Clinical Trial Site | Foley | Alabama | 36535 | — |
| Clinical Trial Site | Huntsville | Alabama | 35801 | — |
| Clinical Trial Site | Huntsville | Alabama | 35805 | — |
| Clinical Trial Site | Montgomery | Alabama | 36117 | — |
| Clinical Trial Site | Gilbert | Arizona | 85297 | — |
| Clinical Trial Site | Phoenix | Arizona | 85028 | — |
| Clinical Trial Site | Sun City | Arizona | 85351 | — |
| Clinical Trial Site | Tempe | Arizona | 85281 | — |
| Clinical Trial Site | Tucson | Arizona | 85741 | — |
| Clinical Trial Site | Beverly Hills | California | 90211 | — |
| Clinical Trial Site | Covina | California | 91723 | — |
| Clinical Trial Site | Encinitas | California | 92024 | — |
| Clinical Trial Site | Garden Grove | California | 92844 | — |
| Clinical Trial Site | Huntington Beach | California | 92647 | — |
| Clinical Trial Site | Los Angeles | California | 90022 | — |
| Clinical Trial Site | Los Angeles | California | 90057 | — |
| Clinical Trial Site | Northridge | California | 91324 | — |
| Clinical Trial Site | Northridge | California | 91325 | — |
| Clinical Trial Site | Pasadena | California | 91105 | — |
| Clinical Trial Site | San Diego | California | 92108 | — |
| Clinical Trial Site | San Diego | California | 92111 | — |
| Clinical Trial Site | San Dimas | California | 91773 | — |
| Clinical Trial Site | Simi Valley | California | 93065 | — |
| Clinical Trial Site | Vacaville | California | 95687 | — |
| Clinical Trial Site | Van Nuys | California | 91405 | — |
| Clinical Trial Site | West Hills | California | 91307 | — |
| Clinical Trial Site | Colorado Springs | Colorado | 80918 | — |
| Clinical Trial Site | Denver | Colorado | 80210 | — |
| Clinical Trial Site | Denver | Colorado | 80230 | — |
| Clinical Trial Site | Hartford | Connecticut | 06112 | — |
| Clinical Trial Site | Middlebury | Connecticut | 06762 | — |
| Clinical Trial Site | Waterbury | Connecticut | 06708 | — |
| Clinical Trial Site | Washington D.C. | District of Columbia | 20009 | — |
| Clinical Trial Site | Clearwater | Florida | 33756 | — |
| Clinical Trial Site | Coral Gables | Florida | 33134 | — |
| Clinical Trial Site | Daytona Beach | Florida | 32117 | — |
| Clinical Trial Site | Fort Myers | Florida | 33912 | — |
| Clinical Trial Site | Hollywood | Florida | 33021 | — |
| Clinical Trial Site | Jacksonville | Florida | 32204 | — |
| Clinical Trial Site | Jacksonville | Florida | 32209 | — |
| Clinical Trial Site | Jacksonville | Florida | 32256 | — |
| Clinical Trial Site | Jensen Beach | Florida | 34957 | — |
| Clinical Trial Site | Lake City | Florida | 32055 | — |
| Clinical Trial Site | Miami | Florida | 33126 | — |
| Clinical Trial Site | Miami | Florida | 33135 | — |
| Clinical Trial Site | Miami | Florida | 33137 | — |
| Clinical Trial Site | Miami | Florida | 33144 | — |
| Clinical Trial Site | Miami | Florida | 33155 | — |
| Clinical Trial Site | Miami | Florida | 33176 | — |
| Clinical Trial Site | Miramar | Florida | 33027 | — |
| Clinical Trial Site | Orlando | Florida | 32801 | — |
| Clinical Trial Site | The Villages | Florida | 32162 | — |
| Clinical Trial Site | Winter Haven | Florida | 33880 | — |
| Clinical Trial Site | Acworth | Georgia | 30101 | — |
| Clinical Trial Site | Atlanta | Georgia | 30322 | — |
| Clinical Trial Site | Columbus | Georgia | 31904 | — |
| Clinical Trial Site | Douglasville | Georgia | 30134 | — |
| Clinical Trial Site | Gainesville | Georgia | 30501 | — |
| Clinical Trial Site | Savannah | Georgia | 31406 | — |
| Clinical Trial Site | Thomasville | Georgia | 31792 | — |
| Clinical Trial Site | Boise | Idaho | 83706 | — |
| Clinical Trial Site | Chicago | Illinois | 60602 | — |
| Clinical Trial Site | Elkhart | Indiana | 46514 | — |
| Clinical Trial Site | Evansville | Indiana | 47714 | — |
| Clinical Trial Site | Richmond | Indiana | 47374 | — |
| Clinical Trial Site | El Dorado | Kansas | 67042 | — |
| Clinical Trial Site | Newton | Kansas | 67114 | — |
| Clinical Trial Site | Wichita | Kansas | 67207 | — |
| Clinical Trial Site | Owensboro | Kentucky | 42303 | — |
| Clinical Trial Site | Monroe | Louisiana | 71201 | — |
| Clinical Trial Site | New Orleans | Louisiana | 70119 | — |
| Clinical Trial Site | Boston | Massachusetts | 02114 | — |
| Clinical Trial Site | West Springfield | Massachusetts | 01089 | — |
| Clinical Trial Site | Flint | Michigan | 48504 | — |
| Clinical Trial Site | Shelby | Michigan | 48315 | — |
| Clinical Trial Site | Ypsilanti | Michigan | 48197 | — |
| Clinical Trial Site | Minneapolis | Minnesota | 55404 | — |
| Clinical Trial Site | Richfield | Minnesota | 55423 | — |
| Clinical Trial Site | Columbus | Mississippi | 39705 | — |
| Clinical Trial Site | Tupelo | Mississippi | 38801 | — |
| Clinical Trial Site | Creve Coeur | Missouri | 63141 | — |
| Clinical Trial Site | Kalispell | Montana | 59901 | — |
| Clinical Trial Site | Lincoln | Nebraska | 68510 | — |
| Clinical Trial Site | Omaha | Nebraska | 68114 | — |
| Clinical Trial Site | Las Vegas | Nevada | 89121 | — |
| Clinical Trial Site | Portsmouth | New Hampshire | 03801 | — |
| Clinical Trial Site | Berlin | New Jersey | 08009 | — |
| Clinical Trial Site | Albuquerque | New Mexico | 87109 | — |
| Clinical Trial Site | New York | New York | 10017 | — |
| Clinical Trial Site | Charlotte | North Carolina | 28287 | — |
| Clinical Trial Site | Durham | North Carolina | 27704 | — |
| Clinical Trial Site | Durham | North Carolina | 27713 | — |
| Clinical Trial Site | Greensboro | North Carolina | 27401 | — |
| Clinical Trial Site | Greenville | North Carolina | 27834 | — |
| Clinical Trial Site | Monroe | North Carolina | 28112 | — |
| Clinical Trial Site | Raleigh | North Carolina | 27609 | — |
| Clinical Trial Site | Wilmington | North Carolina | 28403 | — |
| Clinical Trial Site | Winston-Salem | North Carolina | 27103 | — |
| Clinical Trial Site | Cleveland | Ohio | 44106 | — |
| Clinical Trial Site | Marion | Ohio | 43302 | — |
| Clinical Trial Site | Norman | Oklahoma | 73072 | — |
| Clinical Trial Site | Oklahoma City | Oklahoma | 73102 | — |
| Clinical Trial Site | Bethlehem | Pennsylvania | 18017 | — |
| Clinical Trial Site | Langhorne | Pennsylvania | 19047 | — |
| Clinical Trial Site | Newport | Pennsylvania | 17074 | — |
| Clinical Trial Site | Philadelphia | Pennsylvania | 19114 | — |
| Clinical Trial Site | East Providence | Rhode Island | 02914 | — |
| Clinical Trial Site | Myrtle Beach | South Carolina | 29572 | — |
| Clinical Trial Site | Rapid City | South Dakota | 57701 | — |
| Clinical Trial Site | Chattanooga | Tennessee | 37404 | — |
| Clinical Trial Site | Germantown | Tennessee | 38138 | — |
| Clinical Trial Site | Knoxville | Tennessee | 37909 | — |
| Clinical Trial Site | Knoxville | Tennessee | 37923 | — |
| Clinical Trial Site | Memphis | Tennessee | 38119 | — |
| Clinical Trial Site | Austin | Texas | 78744 | — |
| Clinical Trial Site | Coppell | Texas | 75019 | — |
| Clinical Trial Site | Dallas | Texas | 75230 | — |
| Clinical Trial Site | Dallas | Texas | 75234 | — |
| Clinical Trial Site | El Paso | Texas | 79925 | — |
| Clinical Trial Site | El Paso | Texas | 79935 | — |
| Clinical Trial Site | Houston | Texas | 77002 | — |
| Clinical Trial Site | Houston | Texas | 77024 | — |
| Clinical Trial Site | Houston | Texas | 77054 | — |
| Clinical Trial Site | Houston | Texas | 77081 | — |
| Clinical Trial Site | Houston | Texas | 77099 | — |
| Clinical Trial Site | Magnolia | Texas | 77355 | — |
| Clinical Trial Site | San Antonio | Texas | 78229 | — |
| Clinical Trial Site | San Antonio | Texas | 78240 | — |
| Clinical Trial Site | Shenandoah | Texas | 77384 | — |
| Clinical Trial Site | Sherman | Texas | 75092 | — |
| Clinical Trial Site | Stephenville | Texas | 76401 | — |
| Clinical Trial Site | Tomball | Texas | 77375 | — |
| Clinical Trial Site | Burlington | Vermont | 05401 | — |
| Clinical Trial Site | Burke | Virginia | 22015 | — |
| Clinical Trial Site | Manassas | Virginia | 20109 | — |
| Clinical Trial Site | Norfolk | Virginia | 23504 | — |
| Clinical Trial Site | West Allis | Wisconsin | 53227 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 56 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06272487, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 1, 2026 · Synced May 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06272487 live on ClinicalTrials.gov.