ClinicalTrials.gov record
A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)
ClinicalTrials.gov ID: NCT06292013
Public ClinicalTrials.gov record NCT06292013. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) Who Have Established Atherosclerotic Cardiovascular Disease or Are at Risk for a First Cardiovascular Event - ACCLAIM-Lp(a)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the efficacy of lepodisiran in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke. The study drug will be administered subcutaneously (SC) (under the skin). Approximately 1700 additional participants will be enrolled in an addendum to explore Lp(a) lowering with an alternative dosing schema.
Study identification
- NCT ID
- NCT06292013
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 17,300 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 5, 2024 (Actual)
- Primary completion
- Mar 2029 (Estimated)
- Completion
- Mar 2029 (Estimated)
- Last update posted
- Oct 8, 2026
2024 – 2029
United States locations
- U.S. sites
- 222
- U.S. states
- 39
- U.S. cities
- 174
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Birmingham Clinical Research | Birmingham | Alabama | 35209 | — |
| Alliance for Multispecialty Research, LLC | Daphne | Alabama | 36526 | — |
| SEC Clinical Research | Dothan | Alabama | 36305 | — |
| Alliance for Multispecialty Research, LLC | Mobile | Alabama | 36608 | — |
| Mobile Heart Specialists | Mobile | Alabama | 36608 | — |
| Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC | Gilbert | Arizona | 85296 | — |
| Mercy Gilbert Medical Center | Gilbert | Arizona | 85297 | — |
| Sun City Clinical Research | Glendale | Arizona | 85304 | — |
| Elite Clinical Studies, LLC | Phoenix | Arizona | 85018 | — |
| Helios Clinical Research - Phoenix | Phoenix | Arizona | 85028 | — |
| Absolute Clinical Research | Phoenix | Arizona | 85051 | — |
| Clinical Research Institute of Arizona (CRI) - Sun City West | Sun City West | Arizona | 85375 | — |
| Pima Heart | Tucson | Arizona | 85741 | — |
| Synexus Clinical Research US, Inc./Orange Grove Family Practice | Tucson | Arizona | 85741 | — |
| Eclipse Clinical Research | Tucson | Arizona | 85745 | — |
| Cardiology and Medicine Clinic | Little Rock | Arkansas | 72204 | — |
| National Heart Institute | Beverly Hills | California | 90211 | — |
| Valley Clinical Trials, Inc. | Covina | California | 91723 | — |
| Neighborhood Healthcare Institute of Health | Escondido | California | 92025 | — |
| HB Clinical Trials - Fountain Valley | Fountain Valley | California | 92708 | — |
| Care Access - Huntington Beach | Huntington Beach | California | 92648 | — |
| 310 Clinical Research | Inglewood | California | 90301 | — |
| UCSD - Altman Clinical and Translational Research Institute (ACTRI) | La Jolla | California | 92037-7410 | — |
| Scripps Whittier Diabetes Institute | La Jolla | California | 92037 | — |
| First Valley Medical Group | Lancaster | California | 93534 | — |
| MemorialCare Health System - Long Beach Medical Center | Long Beach | California | 90806 | — |
| Ark Clinical Research | Long Beach | California | 90815 | — |
| Keck School of Medicine of USC | Los Angeles | California | 90033 | — |
| Cardiovascular Research Foundation of Southern California | Los Angeles | California | 90210 | — |
| Valley Clinical Trials, LLC dba Flourish Research | Northridge | California | 91325 | — |
| Desert Oasis Healthcare Medical Group | Palm Springs | California | 92262 | — |
| Artemis Institute for Clinical Research | San Diego | California | 92123 | — |
| Care Access - Santa Clarita | Santa Clarita | California | 91321 | — |
| Stanford University Medical Center | Stanford | California | 94305 | — |
| Olive View-UCLA Medical Center | Sylmar | California | 91342 | — |
| Care Access - Thousand Oaks | Thousand Oaks | California | 91360 | — |
| Med Partners, Inc. dba Premiere Medical Center of Burbank, Inc. | Toluca Lake | California | 91602 | — |
| Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Torrance | California | 90502 | — |
| UCLA South Bay Endocrinology | Torrance | California | 90505 | — |
| InvivoCure | Van Nuys | California | 91405 | — |
| Synexus Clinical Research US, Inc. | Vista | California | 92083 | — |
| Interventional Cardiology Medical Group | West Hills | California | 91307 | — |
| Millennium Clinical Trials | Westlake Village | California | 91361 | — |
| University of Colorado Anschutz Medical Campus | Aurora | Colorado | 80045 | — |
| Bridgeport Hospital | Bridgeport | Connecticut | 06610 | — |
| CMR of Greater New Haven, LLC | Hamden | Connecticut | 06517 | — |
| Hartford Hospital (HH) | Hartford | Connecticut | 06102 | — |
| Cardiology Associates of Fairfield County, P.C. | Stamford | Connecticut | 06905 | — |
| Chase Medical Research, LLC | Waterbury | Connecticut | 06708 | — |
| MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| Excel Medical Clinical Trials | Boca Raton | Florida | 33434 | — |
| Clearwater Cardiovascular & Interventional Consultants M.D., P.A. | Clearwater | Florida | 33756 | — |
| Clinical Research of West Florida, Inc. (Clearwater) | Clearwater | Florida | 33765 | — |
| Jellinger and Lerman, MD PA dba The Center for Diabetes and Endocrine Care | Fort Lauderdale | Florida | 33312 | — |
| Elite Cardiac Research Center | Hialeah | Florida | 33013 | — |
| Westside Center for Clinical Research | Jacksonville | Florida | 32205 | — |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | — |
| Clearwater Cardiovascular & Interventional Consultants M.D., P.A. | Largo | Florida | 33777 | — |
| K2 Medical Research - Maitland | Maitland | Florida | 32751 | — |
| South Florida Clinical Research Institute | Margate | Florida | 33063 | — |
| Flourish Research - Miami, LLC | Miami | Florida | 33135 | — |
| Inpatient Research Clinic | Miami Lakes | Florida | 33014 | — |
| Advanced Research for Health Improvement, LLC | Naples | Florida | 34102 | — |
| Renstar Medical Research | Ocala | Florida | 34470 | — |
| CTR Oakwater, LLC | Orlando | Florida | 32806 | — |
| Florida Institute For Clinical Research, LLC | Orlando | Florida | 32825 | — |
| Innovative Research Institute - Port Charlotte | Port Charlotte | Florida | 33952 | — |
| Peace River Cardiovascular Center | Port Charlotte | Florida | 33952 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| Clearwater Cardiovascular & Interventional Consultants M.D., P.A. | Safety Harbor | Florida | 34695 | — |
| Care Access - Tamarac | Tamarac | Florida | 33321 | — |
| Clinical Research of West Florida | Tampa | Florida | 33606 | — |
| Care Access - Tampa | Tampa | Florida | 33625 | — |
| Cardiology Partners Clinical Research Institute - Wellington | Wellington | Florida | 33449 | — |
| American Clinical Trials - Acworth | Acworth | Georgia | 30101 | — |
| Atlanta Diabetes Associates | Atlanta | Georgia | 30318 | — |
| Emory University School of Medicine | Atlanta | Georgia | 30322 | — |
| Southeastern Clinical Research Institute | Augusta | Georgia | 30904 | — |
| East Coast Institute for Research - Canton | Canton | Georgia | 30114 | — |
| American Clinical Trials - Douglasville | Douglasville | Georgia | 30134 | — |
| Center for Advanced Research & Education | Gainesville | Georgia | 30501 | — |
| Georgia Clinical Research - Lawrenceville | Lawrenceville | Georgia | 30044 | — |
| The Jones Center Clinical Research | Macon | Georgia | 31210 | — |
| North Georgia Clinical Research | Woodstock | Georgia | 30189 | — |
| High Desert Heart & Vascular | Meridian | Idaho | 83642 | — |
| Chicago Clinical Research Institute | Chicago | Illinois | 60607 | — |
| Great Lakes Clinical Trials - Ravenswood | Chicago | Illinois | 60640 | — |
| Clinical Investigation Specialists | Gurnee | Illinois | 60031 | — |
| Alliance for Multispecialty Research, LLC | Niles | Illinois | 60714 | — |
| Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative | Springfield | Illinois | 62702 | — |
| Accellacare - DuPage | Winfield | Illinois | 60190 | — |
| American Health Network of Indiana, LLC - Avon | Avon | Indiana | 46123 | — |
| Indiana University Health Methodist Hospital | Indianapolis | Indiana | 46202 | — |
| Care Access - South Indianapolis | Indianapolis | Indiana | 46254 | — |
| American Health Network of Indiana, LLC - Whiteland | Whiteland | Indiana | 46184 | — |
| Iowa Diabetes and Endocrinology Research Center | West Des Moines | Iowa | 50266 | — |
| Cotton O'Neil Clinical Research Center | Topeka | Kansas | 66606 | — |
| AMR Clinical | Wichita | Kansas | 67226 | — |
| Qualmedica Research | Bowling Green | Kentucky | 42101 | — |
| Alliance for Multispecialty Research, LLC | Lexington | Kentucky | 40509 | — |
| Grace Research - Bossier | Bossier City | Louisiana | 71111 | — |
| Care Access - Lake Charles | Lake Charles | Louisiana | 70601 | — |
| IMA Clinical Research | Monroe | Louisiana | 71201 | — |
| Alliance for Multispecialty Research, LLC | New Orleans | Louisiana | 70119 | — |
| Louisiana Heart Center - Slidell | Slidell | Louisiana | 70458 | — |
| Sinai Hospital Of Baltimore | Baltimore | Maryland | 21209 | — |
| Care Access - Baltimore | Baltimore | Maryland | 21213 | — |
| Ascension Saint Agnes Heart Care | Baltimore | Maryland | 21229 | — |
| MedStar Good Samaritan Hospital | Baltimore | Maryland | 21239 | — |
| Jadestone Clinical Research | Beltsville | Maryland | 20705 | — |
| Flourish Research - Bowie | Bowie | Maryland | 20715 | — |
| Kur Research - Columbia Medical | Columbia | Maryland | 21045 | — |
| Anderson Medical Research | Ft. Washington | Maryland | 20744 | — |
| MedStar Health Research Institute (MedStar Physician Based Research Network) | Hyattsville | Maryland | 20782 | — |
| Brigham and Women's Hospital Diabetes Program | Boston | Massachusetts | 02115 | — |
| NECCR PrimaCare Research | Fall River | Massachusetts | 02721 | — |
| Care Access - Quincy | Quincy | Massachusetts | 02169 | — |
| Alliance for Multispecialty Research, LLC. | Dearborn | Michigan | 48126 | — |
| Revival Research Institute, LLC | Dearborn | Michigan | 48126 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Arcturus Healthcare , PLC, Troy Internal Medicine Research Division | Troy | Michigan | 48098 | — |
| Michigan Heart & Vascular Institute | Ypsilanti | Michigan | 48197 | — |
| Memorial Hospital at Gulfport | Diamondhead | Mississippi | 39525 | — |
| StudyMetrix Research | City of Saint Peters | Missouri | 63303 | — |
| Clinvest Headlands Llc | Springfield | Missouri | 65807 | — |
| Mercury Street Medical Group, PLLC | Butte | Montana | 59701 | — |
| Las Vegas Endocrinology | Henderson | Nevada | 89074 | — |
| DaVita Clinical Research - Las Vegas | Las Vegas | Nevada | 89107 | — |
| Palm Research Center Tenaya | Las Vegas | Nevada | 89128 | — |
| Vector Clinical Trials | Las Vegas | Nevada | 89128 | — |
| Internal Medicine Associates | Bridgeton | New Jersey | 08302 | — |
| Cardio Metabolic Institute | Somerset | New Jersey | 08873 | — |
| Atlantic Health System Overlook Medical Center | Summit | New Jersey | 07901 | — |
| IMA Clinical Research Warren | Warren Township | New Jersey | 07059 | — |
| IMA Clinical Research | Albuquerque | New Mexico | 87109 | — |
| Albany Medical College, Division of Community Endocrinology | Albany | New York | 12203 | — |
| St. Francis Hospital & Heart Center | New Hyde Park | New York | 11576 | — |
| NYU Langone Health | New York | New York | 10016 | — |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | — |
| IMA Clinical Research Manhattan | New York | New York | 10036 | — |
| Lenox Hill Hospital | New York | New York | 10075 | — |
| Northwell Health Physician Peconic | Riverhead | New York | 11901 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| Saratoga Clinical Research | Saratoga Springs | New York | 12866 | — |
| Stony Brook University | Stony Brook | New York | 11794 | — |
| Care Access - Fayetteville | Fayetteville | North Carolina | 28314 | — |
| Medication Management | Greensboro | North Carolina | 27401 | — |
| Triad Clinical Trials | Greensboro | North Carolina | 27410 | — |
| Physician's East Endocrinology | Greenville | North Carolina | 27834 | — |
| IMA Clinical Research Mount Airy | Mount Airy | North Carolina | 27030 | — |
| Accellacare - Raleigh | Raleigh | North Carolina | 27609 | — |
| Accellacare - Wilmington | Wilmington | North Carolina | 28401 | — |
| Wake Forest Baptist Health | Winston-Salem | North Carolina | 27157 | — |
| Velocity Clinical Research, Cleveland | Beachwood | Ohio | 44122 | — |
| Velocity Clinical Research, Mt. Auburn | Cincinnati | Ohio | 45219 | — |
| Velocity Clinical Research, Springdale | Cincinnati | Ohio | 45246 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Ohio State University | Columbus | Ohio | 43210 | — |
| Centricity Research Columbus Ohio Multispecialty | Columbus | Ohio | 43213 | — |
| Good Samaritan Regional Medical Center | Corvallis | Oregon | 97330 | — |
| Lehigh Valley Health Network | Allentown | Pennsylvania | 18103 | — |
| Heritage Valley Multispecialty Group, Inc | Beaver | Pennsylvania | 15009 | — |
| Capital Area Research, LLC | Camp Hill | Pennsylvania | 17011 | — |
| Abington Medical Specialists | Horsham | Pennsylvania | 19044 | — |
| Lancaster General Hospital | Lancaster | Pennsylvania | 17602 | — |
| Penn Medicine: University of Pennsylvania Health System | Philadelphia | Pennsylvania | 19104 | — |
| Clinical Research of Philadelphia | Philadelphia | Pennsylvania | 19114 | — |
| AHN Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| Keystone Clinical Studies | Plymouth Meeting | Pennsylvania | 19462 | — |
| Preferred Primary Care Physicians | Uniontown | Pennsylvania | 15401 | — |
| Cardiology Consultants of Philadelphia Yardley | Yardley | Pennsylvania | 19067 | — |
| Heart and Vascular Research at WellSpan Health | York | Pennsylvania | 17403 | — |
| Accellacare Trident Cardiology | Charleston | South Carolina | 29456 | — |
| Tribe Clinical Research, LLC | Greenville | South Carolina | 29607 | — |
| Walker Family Care | Little River | South Carolina | 29566 | — |
| Care Access - Mauldin | Mauldin | South Carolina | 29662 | — |
| Accellacare - Mt Pleasant | Mt. Pleasant | South Carolina | 29464 | — |
| Monument Health Rapid City Hospital | Rapid City | South Dakota | 57701 | — |
| Alliance for Multispecialty Research, LLC | Knoxville | Tennessee | 37909 | — |
| Care Access - Memphis 2 | Memphis | Tennessee | 38119 | — |
| PharmaTex Research | Amarillo | Texas | 79106 | — |
| Amarillo Heart Clinical Research Institute Inc. | Amarillo | Texas | 79124 | — |
| IMA Clinical Research Austin | Austin | Texas | 78745 | — |
| Velocity Clinical Research, Austin | Austin | Texas | 78759 | — |
| Headlands Horizons LLC | Brownsville | Texas | 78526 | — |
| South Texas Clinical Research | Corpus Christi | Texas | 78404 | — |
| Private Practice - Dr. James E. Race | Dallas | Texas | 75224 | — |
| Baylor Soltero CV Research Center | Dallas | Texas | 75226 | — |
| Zenos Clinical Research | Dallas | Texas | 75230 | — |
| Cedar Health Research | Dallas | Texas | 75251 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Cardio Voyage | Denison | Texas | 75020 | — |
| South Texas Research Institute | Edinburg | Texas | 78539 | — |
| Texas Health Research & Education Institute - Fort Worth | Fort Worth | Texas | 76104 | — |
| Center for Cardiometabolic Disease Prevention/Baylor College of Medicine | Houston | Texas | 77030 | — |
| Juno Research | Houston | Texas | 77040 | — |
| Biopharma Informatic, LLC | Houston | Texas | 77043 | — |
| PlanIt Research, PLLC | Houston | Texas | 77079 | — |
| Research Physicians Network, LLC | Houston | Texas | 77089 | — |
| Accurate Clinical Research - Humble | Humble | Texas | 77338 | — |
| The Heart Institute of East Texas | Lufkin | Texas | 75904 | — |
| Biopharma Informatic, LLC | McAllen | Texas | 78503 | — |
| Wellness Clinical Research | McKinney | Texas | 75069 | — |
| North Texas Research Associates | McKinney | Texas | 75071 | — |
| Revival Research Institute, LLC | McKinney | Texas | 75071 | — |
| Texas Institute of Cardiology, PA | McKinney | Texas | 75071 | — |
| PRX Research | Mesquite | Texas | 75149 | — |
| Southern Endocrinology Associates | Mesquite | Texas | 75149 | — |
| Clinical Advancement Center | San Antonio | Texas | 78212 | — |
| Clinical Trials of Texas, LLC | San Antonio | Texas | 78229 | — |
| IMA Clinical Research San Antonio | San Antonio | Texas | 78229 | — |
| Endeavor Clinical Trials | San Antonio | Texas | 78240 | — |
| Consano Clinical Research, LLC | Shavano Park | Texas | 78231 | — |
| DaVita Clinical Research - North Houston | Shenandoah | Texas | 77384 | — |
| Sherman Clinical Research | Sherman | Texas | 75090 | — |
| Alpine Research Organization | Clinton | Utah | 84015 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| Virginia Heart | Falls Church | Virginia | 22042 | — |
| Alliance for Multispecialty Research, LLC | Norfolk | Virginia | 23502 | — |
| Eastside Research Associates | Redmond | Washington | 98052 | — |
| IMA Clinical Research West Virginia | Morgantown | West Virginia | 26505 | — |
| Clinical Investigation Specialists | Kenosha | Wisconsin | 53144 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 706 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06292013, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 8, 2026 · Synced Oct 24, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06292013 live on ClinicalTrials.gov.