Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

ClinicalTrials.gov ID: NCT06311214

Public ClinicalTrials.gov record NCT06311214. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 7, 2026, 9:03 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Optimizing Antibody-Drug Conjugate Therapy Through Molecular Analysis for Therapy Choice (ADC MATCH)

Study identification

NCT ID: NCT06311214
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: National Cancer Institute (NCI); NIH
Enrollment: 500 participants

Conditions and interventions

Conditions

Interventions

Biopsy Procedure Procedure
Biospecimen Collection Procedure
Computed Tomography Procedure
Echocardiography Test Procedure
Electronic Health Record Review Other
Enfortumab Vedotin Drug
Immunohistochemistry Staining Method Other
Magnetic Resonance Imaging Procedure
Multigated Acquisition Scan Procedure
Sacituzumab Govitecan Biological
Trastuzumab Deruxtecan Biological

Procedure · Other · Drug + 1 more

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 17, 2025
Primary completion: Mar 30, 2028
Completion: Mar 30, 2028
Last update posted: Apr 12, 2026

2025 – 2028

United States locations

U.S. sites: 27
U.S. states: 15
U.S. cities: 23

Facility	City	State	ZIP	Site status
City of Hope Comprehensive Cancer Center	Duarte	California	91010	Recruiting
UC San Diego Health System - Encinitas	Encinitas	California	92024	Recruiting
City of Hope at Irvine Lennar	Irvine	California	92618	Recruiting
UC San Diego Moores Cancer Center	La Jolla	California	92093	Recruiting
UC San Diego Medical Center - Hillcrest	San Diego	California	92103	Recruiting
Yale University	New Haven	Connecticut	06520	Recruiting
Smilow Cancer Hospital Care Center-Trumbull	Trumbull	Connecticut	06611	Recruiting
UF Health Cancer Institute - Gainesville	Gainesville	Florida	32610	Recruiting
Northwestern University	Chicago	Illinois	60611	Recruiting
University of Kentucky/Markey Cancer Center	Lexington	Kentucky	40536	Recruiting
Ochsner Medical Center Jefferson	New Orleans	Louisiana	70121	Recruiting
Dana-Farber Cancer Institute	Boston	Massachusetts	02215	Recruiting
Siteman Cancer Center at Saint Peters Hospital	City of Saint Peters	Missouri	63376	Recruiting
Siteman Cancer Center at West County Hospital	Creve Coeur	Missouri	63141	Recruiting
Washington University School of Medicine	St Louis	Missouri	63110	Recruiting
Siteman Cancer Center-South County	St Louis	Missouri	63129	Recruiting
Siteman Cancer Center at Christian Hospital	St Louis	Missouri	63136	Recruiting
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center	New York	New York	10032	Recruiting
Ohio State University Comprehensive Cancer Center	Columbus	Ohio	43210	Recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Recruiting
Vanderbilt Breast Center at One Hundred Oaks	Nashville	Tennessee	37204	Recruiting
Vanderbilt University/Ingram Cancer Center	Nashville	Tennessee	37232	Recruiting
M D Anderson Cancer Center	Houston	Texas	77030	Recruiting
University of Virginia Cancer Center	Charlottesville	Virginia	22908	Recruiting
VCU Massey Comprehensive Cancer Center	Richmond	Virginia	23298	Recruiting
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center	Madison	Wisconsin	53718	Recruiting
University of Wisconsin Carbone Cancer Center - University Hospital	Madison	Wisconsin	53792	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06311214, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 12, 2026 · Synced May 7, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06311214 live on ClinicalTrials.gov.

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