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Recruiting Phase 2 Interventional

To Evaluate the Safety and Efficacy of MANP in Subjects With Difficult to Control/ Resistant Hypertension

ClinicalTrials.gov ID: NCT06343298

Public ClinicalTrials.gov record NCT06343298. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 23, 2026, 9:39 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, DOSE TITRATION, MULTI-CENTER STUDY TO EVALUATE THE SAFETY AND EFFICACY OF SUBCUTANEOUS MANP WHEN ADMINISTERED ONCE DAILY FOR 42 DAYS IN PARTICIPANTS WITH DIFFICULT TO CONTROL HYPERTENSION/RESISTANT HYPERTENSION

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This is a Phase 2 dose-titration study designed to evaluate the safety and efficacy of MANP subcutaneous injection compared to placebo in reducing baseline daytime systolic blood pressure (SBP), derived from 24-hour ambulatory blood pressure monitoring (ABPM), in subjects with hypertension who are taking 3 or more antihypertensive medications with different mechanisms of action.

Study identification

NCT ID
NCT06343298
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 2
Lead sponsor
E-Star BioTech, LLC
Industry
Enrollment
120 participants

Conditions and interventions

Interventions

Drug · Other

Eligibility (public fields only)

Age range
18 Years to 80 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Nov 17, 2024 (Actual)
Primary completion
Jul 1, 2027 (Estimated)
Completion
Sep 30, 2027 (Estimated)
Last update posted
Sep 23, 2026

2024 – 2027

United States locations

U.S. sites
23
U.S. states
10
U.S. cities
22
Facility City State ZIP Site status
Lynn Institute of the Ozarks Little Rock Arkansas 72204 Recruiting
Orange County Research Center Lake Forest California 92630 Recruiting
Office of Dr. Edward Portnoy MD Westlake Village California 91361 Recruiting
Arrow Clinical Trials Daytona Beach Florida 32117 Recruiting
Royal Research Corp Hollywood Florida 33021 Recruiting
Evolution Clinical Trials Miami Florida 33122 Recruiting
Cowry Health Acworth Georgia 30101 Recruiting
SKY CRNG Union City Georgia 30291 Recruiting
Cedar Crosse Research Center Chicago Illinois 60607 Recruiting
Revival Research Institute, LLC Dearborn Michigan 48126 Recruiting
Aa Mrc Llc Flint Michigan 48504 Recruiting
SKY CRNG Ridgeland Mississippi 39157 Recruiting
Mt.Sinai New York New York 10029 Recruiting
Monroe Biomedical Research Monroe North Carolina 28112 Recruiting
Prime Research Coppell Texas 75019 Active, not recruiting
Dallas Renal Group Dallas Texas 75230 Recruiting
Revival Research Denton Texas 76210 Recruiting
Aavon Clinical research Houston Texas 77074 Recruiting
Pioneer Research Solutions Houston Texas 77099 Recruiting
Prime Clinical Research Mansfield Texas 76063 Recruiting
Clinical Investigations of Texas Plano Texas 75075 Recruiting
Aavon Clinical Trials Richmond Texas 77407 Recruiting
Revival Research Sherman Texas 75092 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06343298, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Sep 23, 2026 · Synced Oct 23, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT06343298 live on ClinicalTrials.gov.

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