To Evaluate the Safety and Efficacy of MANP in Subjects With Difficult to Control/ Resistant Hypertension
Public ClinicalTrials.gov record NCT06343298. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, DOSE TITRATION, MULTI-CENTER STUDY TO EVALUATE THE SAFETY AND EFFICACY OF SUBCUTANEOUS MANP WHEN ADMINISTERED ONCE DAILY FOR 42 DAYS IN PARTICIPANTS WITH DIFFICULT TO CONTROL HYPERTENSION/RESISTANT HYPERTENSION
Study identification
- NCT ID
- NCT06343298
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- E-Star BioTech, LLC
- Industry
- Enrollment
- 120 participants
Conditions and interventions
Conditions
Interventions
- MANP Drug
- Placebo Matched control Other
Drug · Other
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 16, 2024
- Primary completion
- Jun 30, 2026
- Completion
- Aug 31, 2026
- Last update posted
- Oct 5, 2025
2024 – 2026
United States locations
- U.S. sites
- 29
- U.S. states
- 10
- U.S. cities
- 28
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Lynn Institute of the Ozarks | Little Rock | Arkansas | 72204 | Recruiting |
| Amicis Research Center - Beverly Hills | Beverly Hills | California | 90211 | Recruiting |
| Amicis Research Center - Granada Hills | Granada Hills | California | 91344 | Recruiting |
| Orange County Research Center | Lake Forest | California | 92630 | Recruiting |
| Amicis Research Center - Palmdale | Palmdale | California | 93551 | Recruiting |
| Amicis Research Site - Valencia | Valencia | California | 91355 | Recruiting |
| Interventional Cardiology Medical Group | West Hills | California | 91308 | Withdrawn |
| Office of Dr. Edward Portnoy MD | Westlake Village | California | 91361 | Recruiting |
| SM Research Center | Biscayne Park | Florida | 33161 | Recruiting |
| Arrow Clinical Trials | Daytona Beach | Florida | 32117 | Recruiting |
| Royal Research Corp | Hollywood | Florida | 33021 | Recruiting |
| Evolution Clinical Trials | Miami | Florida | 33122 | Recruiting |
| Cowry Health | Acworth | Georgia | 30101 | Recruiting |
| Alta Pharmaceutical Research Center | Peachtree Corners | Georgia | 30092 | Recruiting |
| Cedar Crosse Research Center | Chicago | Illinois | 60607 | Recruiting |
| Revival Research Institute, LLC | Dearborn | Michigan | 48126 | Recruiting |
| Aa Mrc Llc | Flint | Michigan | 48504 | Recruiting |
| Monroe Biomedical Research | Monroe | North Carolina | 28112 | Recruiting |
| Superior Clinical Research | Smithfield | North Carolina | 27577 | Recruiting |
| K&R Research LLC | Marion | Ohio | 43302 | Recruiting |
| Tristar Clinical Investigations, P.C. | Philadelphia | Pennsylvania | 19114 | Active, not recruiting |
| Prime Research | Coppell | Texas | 75019 | Active, not recruiting |
| Dallas Renal Group | Dallas | Texas | 75230 | Recruiting |
| East Texas Cardiology | Houston | Texas | 77002 | Recruiting |
| Pioneer Research Solutions | Houston | Texas | 77099 | Recruiting |
| Prime Clinical Research | Mansfield | Texas | 76063 | Recruiting |
| Clinical Investigations of Texas | Plano | Texas | 75075 | Recruiting |
| Aavon Clinical Trials | Richmond | Texas | 77407 | Recruiting |
| Revival Research | Sherman | Texas | 75092 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06343298, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 5, 2025 · Synced Jul 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06343298 live on ClinicalTrials.gov.