Study of Plozasiran (ARO-APOC3) in Adults With Severe Hypertriglyceridemia
Public ClinicalTrials.gov record NCT06347003. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Plozasiran in Adults With Severe Hypertriglyceridemia
Study identification
- NCT ID
- NCT06347003
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Arrowhead Pharmaceuticals
- Industry
- Enrollment
- 446 participants
Conditions and interventions
Conditions
Interventions
- Placebo Drug
- Plozasiran Injection Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 21, 2024
- Primary completion
- May 31, 2026
- Completion
- Aug 31, 2026
- Last update posted
- Oct 26, 2025
2024 – 2026
United States locations
- U.S. sites
- 52
- U.S. states
- 20
- U.S. cities
- 45
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Center 1 | Garden Grove | California | 92844 | — |
| Research Center 2 | Lake Forest | California | 92630 | — |
| Research Center 3 | Montclair | California | 91763 | — |
| Research Center 4 | Panorama City | California | 91402 | — |
| Research Center 5 | Redding | California | 96001 | — |
| Research Center 6 | Colorado Springs | Colorado | 80909 | — |
| Research Center 7 | Hialeah | Florida | 33016 | — |
| Research Center 8 | Lake City | Florida | 32055 | — |
| Research Center 9 | Miami Lakes | Florida | 33014 | — |
| Research Center 10 | Mt. Dora | Florida | 32757 | — |
| Research Center 11 | Orlando | Florida | 32825 | — |
| Research Center 12 | Pensacola | Florida | 32503 | — |
| Research Center 13 | Tamarac | Florida | 33321 | — |
| Research Center 14 | Tampa | Florida | 33614 | — |
| Research Center 15 | Macon | Georgia | 31210 | — |
| Research Center 16 | Savannah | Georgia | 31401 | — |
| Research Center 17 | Park Ridge | Illinois | 60068 | — |
| Research Center 18 | Eunice | Louisiana | 70535 | — |
| Research Center 19 | Baltimore | Maryland | 21229 | — |
| Research Center 20 | Flint | Michigan | 48532 | — |
| Research Center 21 | Minneapolis | Minnesota | 55455 | — |
| Research Center 22 | Olive Branch | Mississippi | 38654 | — |
| Research Center 23 | Jefferson City | Missouri | 65109 | — |
| Research Center 24 | St Louis | Missouri | 63136 | — |
| Research Center 26 | Omaha | Nebraska | 68114 | — |
| Research Center 25 | Omaha | Nebraska | 68144 | — |
| Research Center 27 | Las Vegas | Nevada | 89119 | — |
| Research Center 29 | Long Island City | New York | 11106 | — |
| Research Center 30 | New York | New York | 10016 | — |
| Research Center 31 | Rochester | New York | 14642 | — |
| Research Center 28 | The Bronx | New York | 10455 | — |
| Research Center 32 | Vestal | New York | 13850 | — |
| Research Center 33 | Morehead City | North Carolina | 28557 | — |
| Research Center 34 | Winston-Salem | North Carolina | 27157 | — |
| Research Center 35 | Cincinnati | Ohio | 45219 | — |
| Research Center 36 | Columbus | Ohio | 43210 | — |
| Research Center 37 | Norman | Oklahoma | 73072 | — |
| Research Center 38 | Oklahoma City | Oklahoma | 73111 | — |
| Research Center 39 | Powell | Tennessee | 37849 | — |
| Research Center 40 | El Paso | Texas | 79905 | — |
| Research Center 47 | Houston | Texas | 77029 | — |
| Research Center 45 | Houston | Texas | 77030 | — |
| Research Center 46 | Houston | Texas | 77030 | — |
| Research Center 42 | Houston | Texas | 77061 | — |
| Research Center 44 | Houston | Texas | 77074 | — |
| Research Center 43 | Houston | Texas | 77079 | — |
| Research Center 41 | Houston | Texas | 77095 | — |
| Research Center 48 | Laredo | Texas | 78041 | — |
| Research Center 49 | Missouri City | Texas | 77459 | — |
| Research Center 50 | Plano | Texas | 75093 | — |
| Research Center 51 | San Antonio | Texas | 78230 | — |
| Research Center 52 | Seattle | Washington | 98109 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 144 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06347003, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 26, 2025 · Synced May 18, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06347003 live on ClinicalTrials.gov.