Phase 3 Study of Plozasiran in Adults With Hypertriglyceridemia
Public ClinicalTrials.gov record NCT06347133. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Plozasiran in Adults With Hypertriglyceridemia
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This Phase 3 study will evaluate the safety and efficacy of plozasiran injection (ARO-APOC3) in adult participants with hypertriglyceridemia (HTG). After providing informed consent eligible participants will be randomized to receive 4 doses (once every 3 months) of plozasiran or placebo and be evaluated for efficacy and safety.
Study identification
- NCT ID
- NCT06347133
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,456 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 21, 2024 (Actual)
- Primary completion
- Jun 1, 2026 (Actual)
- Completion
- Sep 8, 2026 (Actual)
- Last update posted
- Sep 25, 2026
2024 – 2026
United States locations
- U.S. sites
- 97
- U.S. states
- 29
- U.S. cities
- 83
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site 1 | Birmingham | Alabama | 35205 | — |
| Research Site 2 | Mobile | Alabama | 36604 | — |
| Research Site 3 | Beverly Hills | California | 90211 | — |
| Research Site 4 | Canoga Park | California | 91303 | — |
| Research Site 5 | Garden Grove | California | 92844 | — |
| Research Site 6 | Huntington Beach | California | 92648 | — |
| Research Site 7 | Lake Forest | California | 92630 | — |
| Research Site 8 | Lincoln | California | 95648 | — |
| Research Site 9 | Long Beach | California | 90822 | — |
| Research Site 10 | Montclair | California | 91763 | — |
| Research Site 11 | Oxnard | California | 93030 | — |
| Research Site 12 | Redding | California | 96001 | — |
| Research Site 13 | Van Nuys | California | 91402 | — |
| Research Site 14 | Colorado Springs | Colorado | 80909 | — |
| Research Site 15 | Clearwater | Florida | 33756 | — |
| Research Site 16 | Hialeah | Florida | 33016 | — |
| Research Site 17 | Lake City | Florida | 32055 | — |
| Research Site 18 | Miami Lakes | Florida | 33014 | — |
| Research Site 19 | Mt. Dora | Florida | 32757 | — |
| Research Site 20 | North Miami Beach | Florida | 33162 | — |
| Research Site 21 | Orlando | Florida | 32825 | — |
| Research Site 22 | Pensacola | Florida | 32503 | — |
| Research Site 23 | Sarasota | Florida | 34239 | — |
| Research Site 24 | Tamarac | Florida | 33321 | — |
| Research Site 25 | Lawrenceville | Georgia | 30044 | — |
| Research Site 26 | Macon | Georgia | 31210 | — |
| Research Site 27 | Savannah | Georgia | 31406 | — |
| Research Site 28 | Sugar Hill | Georgia | 30518 | — |
| Research Site 29 | Park Ridge | Illinois | 60068 | — |
| Research Site 30 | Elkhart | Indiana | 46514 | — |
| Research Site 31 | Indianapolis | Indiana | 46290 | — |
| Research Site 32 | South Bend | Indiana | 46617 | — |
| Research Site 33 | Overland Park | Kansas | 66211 | — |
| Research Site 34 | Topeka | Kansas | 66606 | — |
| Research Site 35 | Louisville | Kentucky | 40202 | — |
| Research Site 36 | Zachary | Louisiana | 70791 | — |
| Research Site 37 | Annapolis | Maryland | 21401 | — |
| Research Site 38 | Baltimore | Maryland | 21229 | — |
| Research Site 39 | Flint | Michigan | 48532 | — |
| Research Site 40 | Minneapolis | Minnesota | 55455 | — |
| Research Site 41 | Olive Branch | Mississippi | 38654 | — |
| Research Site 42 | Jefferson City | Missouri | 65109 | — |
| Research Site 43 | St Louis | Missouri | 63136 | — |
| Research Site 44 | Norfolk | Nebraska | 68701 | — |
| Research Site 46 | Omaha | Nebraska | 68114 | — |
| Research Site 45 | Omaha | Nebraska | 68144 | — |
| Research Site 47 | Las Vegas | Nevada | 89119 | — |
| Research Site 48 | Summit | New Jersey | 07901 | — |
| Research Site 52 | New York | New York | 10016 | — |
| Research Site 51 | New York | New York | 10029 | — |
| Research Site 53 | Riverhead | New York | 11901 | — |
| Research Site 54 | Rochester | New York | 14642 | — |
| Research Site 49 | The Bronx | New York | 10455 | — |
| Research Site 50 | The Bronx | New York | 10461 | — |
| Research Site 55 | Vestal | New York | 13850 | — |
| Research Site 56 | Asheboro | North Carolina | 27203 | — |
| Research Site 57 | Morehead City | North Carolina | 28557 | — |
| Research Site 58 | Wilmington | North Carolina | 28412 | — |
| Research Site 59 | Winston-Salem | North Carolina | 27157 | — |
| Research Site 60 | Beavercreek | Ohio | 45431 | — |
| Research Site 61 | Cincinnati | Ohio | 45267 | — |
| Research Site 63 | Columbus | Ohio | 43210 | — |
| Research Site 62 | Columbus | Ohio | 43214 | — |
| Research Site 64 | Norman | Oklahoma | 73072 | — |
| Research Site 66 | Oklahoma City | Oklahoma | 73111 | — |
| Research Site 65 | Oklahoma City | Oklahoma | 73112 | — |
| Research Site 67 | Horsham | Pennsylvania | 19044 | — |
| Research Site 68 | Newport | Pennsylvania | 17074 | — |
| Research Site 69 | Newport | Pennsylvania | 17074 | — |
| Research Site 70 | Philadelphia | Pennsylvania | 19104 | — |
| Research Site 71 | Wilkes-Barre | Pennsylvania | 18711 | — |
| Research Site 72 | Fort Mill | South Carolina | 29707 | — |
| Research Site 73 | Greenville | South Carolina | 29607 | — |
| Research Site 74 | Chattanooga | Tennessee | 37411 | — |
| Research Site 75 | Powell | Tennessee | 37849 | — |
| Research Site 76 | El Paso | Texas | 79905 | — |
| Research Site 77 | Fort Worth | Texas | 76132 | — |
| Research Site 86 | Houston | Texas | 77029 | — |
| Research Site 84 | Houston | Texas | 77030 | — |
| Research Site 85 | Houston | Texas | 77030 | — |
| Research Site 78 | Houston | Texas | 77040 | — |
| Research Site 80 | Houston | Texas | 77061 | — |
| Research Site 83 | Houston | Texas | 77074 | — |
| Research Site 82 | Houston | Texas | 77079 | — |
| Research Site 79 | Houston | Texas | 77090 | — |
| Research Site 81 | Houston | Texas | 77095 | — |
| Research Site 87 | Laredo | Texas | 78041 | — |
| Research Site 88 | Missouri City | Texas | 77459 | — |
| Research Site 89 | Plano | Texas | 75093 | — |
| Research Site 90 | San Antonio | Texas | 78230 | — |
| Research Site 91 | Sugar Land | Texas | 77479 | — |
| Research Site 92 | Tomball | Texas | 77375 | — |
| Research Site 93 | Victoria | Texas | 77901 | — |
| Research Site 94 | Bountiful | Utah | 84010 | — |
| Research Site 95 | St. George | Utah | 84790 | — |
| Research Site 96 | Manassas | Virginia | 20110 | — |
| Research Site 97 | Seattle | Washington | 98109 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 138 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06347133, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 25, 2026 · Synced Oct 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06347133 live on ClinicalTrials.gov.