Progressing TAAR-1, Dopamine, and Norepinephrine in Depression Using Solriamfetol
Public ClinicalTrials.gov record NCT06360419. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled Trial of Solriamfetol in Subjects With Major Depressive Disorder
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
PARADIGM (Progressing TAAR-1, Dopamine, and Norepinephrine in Depression Using Solriamfetol) is a Phase 3, randomized, double-blind, placebo-controlled, multicenter trial to assess the safety and efficacy of solriamfetol for the treatment of major depressive disorder (MDD) in adults.
Study identification
- NCT ID
- NCT06360419
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 346 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 18, 2024 (Actual)
- Primary completion
- Dec 31, 2024 (Actual)
- Completion
- Mar 26, 2025 (Actual)
- Last update posted
- Jan 5, 2026
2024 – 2025
United States locations
- U.S. sites
- 40
- U.S. states
- 18
- U.S. cities
- 38
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Clinical Research Site | Little Rock | Arkansas | 72211 | — |
| Clinical Research Site | Bellflower | California | 90706 | — |
| Clinical Research Site | Encino | California | 91316 | — |
| Clinical Research Site | Lemon Grove | California | 91945 | — |
| Clinical Research Site | Los Angeles | California | 90015 | — |
| Clinical Research Site | Montclair | California | 91763 | — |
| Clinical Research Site | Oceanside | California | 92056 | — |
| Clinical Research Site | Redlands | California | 92374 | — |
| Clinical Research Site | Riverside | California | 92506 | — |
| Clinical Research Site | Sherman Oaks | California | 91403 | — |
| Clinical Research Site | Torrance | California | 90501 | — |
| Clinical Research Site | Upland | California | 91786 | — |
| Clinical Research Site | Walnut Creek | California | 94596 | — |
| Clinical Research Site | Cromwell | Connecticut | 06416 | — |
| Clinical Research Site | Brandon | Florida | 33511 | — |
| Clinical Research Site | Hialeah | Florida | 33012 | — |
| Clinical Research Site | Jacksonville | Florida | 32256 | — |
| Clinical Research Site | Orlando | Florida | 32801 | — |
| Clinical Research Site | Orlando | Florida | 32806 | — |
| Clinical Research Site | Orlando | Florida | 32807 | — |
| Clinical Research Site | Chicago | Illinois | 60634 | — |
| Clinical Research Site | Overland Park | Kansas | 66210 | — |
| Clinical Research Site | New Orleans | Louisiana | 70115 | — |
| Clinical Research Site | Boston | Massachusetts | 02131 | — |
| Clinical Research Site | Saint Charles | Missouri | 63304 | — |
| Clinical Research Site | Las Vegas | Nevada | 89102 | — |
| Clinical Research Site | Brooklyn | New York | 11235 | — |
| Clinical Research Site | Rochester | New York | 14609 | — |
| Clinical Research Site | Staten Island | New York | 10314 | — |
| Clinical Research Site | Hickory | North Carolina | 28601 | — |
| Clinical Research Site | Cincinnati | Ohio | 45215 | — |
| Clinical Research Site | Oklahoma City | Oklahoma | 73116 | — |
| Clinical Research Site | Media | Pennsylvania | 19063 | — |
| Clinical Research Site | Philadelphia | Pennsylvania | 19104 | — |
| Clinical Research Site | Memphis | Tennessee | 38119 | — |
| Clinical Research Site | Austin | Texas | 78737 | — |
| Clinical Research Site | Dallas | Texas | 75231 | — |
| Clinical Research Site | Friendswood | Texas | 77546 | — |
| Clinical Research Site | Wichita Falls | Texas | 76309 | — |
| Clinical Research Site | Everett | Washington | 98201 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06360419, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 5, 2026 · Synced Oct 30, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06360419 live on ClinicalTrials.gov.