A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma

ClinicalTrials.gov ID: NCT06368817

Public ClinicalTrials.gov record NCT06368817. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 6, 2026, 2:07 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase II Trial Evaluating Chemotherapy Followed by Response-Based Reduced Radiation Therapy for Patients With Central Nervous System Germinomas

Study identification

NCT ID: NCT06368817
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Children's Oncology Group; Network
Enrollment: 240 participants

Conditions and interventions

Conditions

Interventions

3-Dimensional Conformal Proton Radiation Therapy Radiation
3-Dimensional Conformal Radiation Therapy Radiation
Biospecimen Collection Procedure
Carboplatin Drug
Etoposide Drug
Intensity-Modulated Proton Therapy Procedure
Intensity-Modulated Radiation Therapy Radiation
Lumbar Puncture Procedure
Magnetic Resonance Imaging Procedure
Questionnaire Administration Other
Surgical Procedure Procedure

Radiation · Procedure · Drug + 1 more

Eligibility (public fields only)

Age range: 3 Years to 29 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 21, 2024
Primary completion: Nov 3, 2033
Completion: Nov 3, 2033
Last update posted: May 3, 2026

2024 – 2033

United States locations

U.S. sites: 92
U.S. states: 42
U.S. cities: 75

Facility	City	State	ZIP	Site status
USA Health Strada Patient Care Center	Mobile	Alabama	36604	Recruiting
Phoenix Childrens Hospital	Phoenix	Arizona	85016	Recruiting
Arkansas Children's Hospital	Little Rock	Arkansas	72202-3591	Recruiting
Loma Linda University Medical Center	Loma Linda	California	92354	Recruiting
Children's Hospital Los Angeles	Los Angeles	California	90027	Recruiting
UCSF Benioff Children's Hospital Oakland	Oakland	California	94609	Recruiting
Children's Hospital of Orange County	Orange	California	92868	Recruiting
Lucile Packard Children's Hospital Stanford University	Palo Alto	California	94304	Recruiting
Rady Children's Hospital - San Diego	San Diego	California	92123	Recruiting
UCSF Medical Center-Mission Bay	San Francisco	California	94158	Recruiting
Children's Hospital Colorado	Aurora	Colorado	80045	Recruiting
Connecticut Children's Medical Center	Hartford	Connecticut	06106	Recruiting
Alfred I duPont Hospital for Children	Wilmington	Delaware	19803	Recruiting
Children's National Medical Center	Washington D.C.	District of Columbia	20010	Recruiting
Memorial Regional Hospital/Joe DiMaggio Children's Hospital	Hollywood	Florida	33021	Recruiting
Nemours Children's Clinic-Jacksonville	Jacksonville	Florida	32207	Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center	Miami	Florida	33136	Recruiting
Nicklaus Children's Hospital	Miami	Florida	33155	Recruiting
Arnold Palmer Hospital for Children	Orlando	Florida	32806	Recruiting
Nemours Children's Hospital	Orlando	Florida	32827	Recruiting
Nemours Children's Clinic - Pensacola	Pensacola	Florida	32504	Recruiting
Sacred Heart Hospital	Pensacola	Florida	32504	Active, not recruiting
Johns Hopkins All Children's Hospital	St. Petersburg	Florida	33701	Recruiting
Saint Joseph's Hospital/Children's Hospital-Tampa	Tampa	Florida	33607	Recruiting
Children's Healthcare of Atlanta - Arthur M Blank Hospital	Atlanta	Georgia	30329	Recruiting
Kapiolani Medical Center for Women and Children	Honolulu	Hawaii	96826	Recruiting
Saint Luke's Cancer Institute - Boise	Boise	Idaho	83712	Recruiting
Lurie Children's Hospital-Chicago	Chicago	Illinois	60611	Recruiting
University of Illinois	Chicago	Illinois	60612	Recruiting
University of Chicago Comprehensive Cancer Center	Chicago	Illinois	60637	Recruiting
Loyola University Medical Center	Maywood	Illinois	60153	Recruiting
Riley Hospital for Children	Indianapolis	Indiana	46202	Recruiting
University of Iowa/Holden Comprehensive Cancer Center	Iowa City	Iowa	52242	Recruiting
Norton Children's Hospital	Louisville	Kentucky	40202	Recruiting
Johns Hopkins University/Sidney Kimmel Cancer Center	Baltimore	Maryland	21287	Recruiting
Dana-Farber Cancer Institute	Boston	Massachusetts	02215	Recruiting
C S Mott Children's Hospital	Ann Arbor	Michigan	48109	Recruiting
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital	Grand Rapids	Michigan	49503	Recruiting
Children's Hospitals and Clinics of Minnesota - Minneapolis	Minneapolis	Minnesota	55404	Recruiting
University of Minnesota/Masonic Cancer Center	Minneapolis	Minnesota	55455	Recruiting
Mayo Clinic in Rochester	Rochester	Minnesota	55905	Recruiting
University of Mississippi Medical Center	Jackson	Mississippi	39216	Recruiting
Children's Mercy Hospitals and Clinics	Kansas City	Missouri	64108	Recruiting
Cardinal Glennon Children's Medical Center	St Louis	Missouri	63104	Recruiting
Washington University School of Medicine	St Louis	Missouri	63110	Recruiting
Children's Hospital and Medical Center of Omaha	Omaha	Nebraska	68114	Recruiting
University of Nebraska Medical Center	Omaha	Nebraska	68198	Recruiting
Alliance for Childhood Diseases/Cure 4 the Kids Foundation	Las Vegas	Nevada	89135	Recruiting
Summerlin Hospital Medical Center	Las Vegas	Nevada	89144	Recruiting
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center	Lebanon	New Hampshire	03756	Recruiting
Hackensack University Medical Center	Hackensack	New Jersey	07601	Recruiting
Saint Peter's University Hospital	New Brunswick	New Jersey	08901	Recruiting
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital	New Brunswick	New Jersey	08903	Recruiting
Newark Beth Israel Medical Center	Newark	New Jersey	07112	Recruiting
Saint Joseph's Regional Medical Center	Paterson	New Jersey	07503	Recruiting
Albany Medical Center	Albany	New York	12208	Recruiting
The Steven and Alexandra Cohen Children's Medical Center of New York	New Hyde Park	New York	11040	Recruiting
Laura and Isaac Perlmutter Cancer Center at NYU Langone	New York	New York	10016	Recruiting
Mount Sinai Hospital	New York	New York	10029	Recruiting
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center	New York	New York	10032	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
State University of New York Upstate Medical University	Syracuse	New York	13210	Recruiting
Montefiore Medical Center - Moses Campus	The Bronx	New York	10467	Recruiting
UNC Lineberger Comprehensive Cancer Center	Chapel Hill	North Carolina	27599	Recruiting
Wake Forest University Health Sciences	Winston-Salem	North Carolina	27157	Recruiting
Sanford Broadway Medical Center	Fargo	North Dakota	58122	Recruiting
Rainbow Babies and Childrens Hospital	Cleveland	Ohio	44106	Recruiting
Nationwide Children's Hospital	Columbus	Ohio	43205	Recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Recruiting
Oregon Health and Science University	Portland	Oregon	97239	Recruiting
Children's Hospital of Philadelphia	Philadelphia	Pennsylvania	19104	Recruiting
Saint Christopher's Hospital for Children	Philadelphia	Pennsylvania	19134	Recruiting
Children's Hospital of Pittsburgh of UPMC	Pittsburgh	Pennsylvania	15224	Recruiting
Rhode Island Hospital	Providence	Rhode Island	02903	Recruiting
Prisma Health Richland Hospital	Columbia	South Carolina	29203	Recruiting
BI-LO Charities Children's Cancer Center	Greenville	South Carolina	29605	Recruiting
Sanford USD Medical Center - Sioux Falls	Sioux Falls	South Dakota	57117-5134	Recruiting
Saint Jude Children's Research Hospital	Memphis	Tennessee	38105	Recruiting
Dell Children's Medical Center of Central Texas	Austin	Texas	78723	Recruiting
Driscoll Children's Hospital	Corpus Christi	Texas	78411	Recruiting
Medical City Dallas Hospital	Dallas	Texas	75230	Recruiting
UT Southwestern/Simmons Cancer Center-Dallas	Dallas	Texas	75390	Recruiting
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center	Houston	Texas	77030	Recruiting
M D Anderson Cancer Center	Houston	Texas	77030	Recruiting
Children's Hospital of San Antonio	San Antonio	Texas	78207	Recruiting
University of Texas Health Science Center at San Antonio	San Antonio	Texas	78229	Recruiting
Primary Children's Hospital	Salt Lake City	Utah	84113	Recruiting
University of Virginia Cancer Center	Charlottesville	Virginia	22908	Recruiting
Children's Hospital of The King's Daughters	Norfolk	Virginia	23507	Recruiting
Seattle Children's Hospital	Seattle	Washington	98105	Recruiting
Providence Sacred Heart Medical Center and Children's Hospital	Spokane	Washington	99204	Recruiting
University of Wisconsin Carbone Cancer Center - University Hospital	Madison	Wisconsin	53792	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 17 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06368817, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 3, 2026 · Synced May 6, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06368817 live on ClinicalTrials.gov.

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