ReNEW:Phase 3 Study of Efficacy, Safety & Pharmacokinetics of Subcutaneous Injections of Elamipretide in Subjects With Dry Age-Related Macular Degeneration (Dry AMD)
Public ClinicalTrials.gov record NCT06373731. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
ReNEW: A Phase 3, Double-Masked, Placebo-Controlled Clinical Trial to Evaluate the Efficacy, Safety, and Pharmacokinetics of Subcutaneous Injections of Elamipretide in Subjects Who Have Dry Age-Related Macular Degeneration (Dry AMD)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The goal of this clinical trial is to evaluate the efficacy, safety and pharmacokinetics of elamipretide in subjects with dry age-related macular degeneration (AMD). The main questions it aims to answer are: what is the rate of change in the macular area of photoreceptor loss in subjects who receive a daily dose of elamipretide compared with those who receive a look-alike substance that contains no active drug, and what is the safety and tolerability of elamipretide daily subcutaneous injections. Participants will receive either once daily subcutaneous doses of 40mg elamipretide or placebo and the two treatment groups will be compared.
Study identification
- NCT ID
- NCT06373731
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 313 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 55 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 30, 2024 (Actual)
- Primary completion
- Aug 2027 (Estimated)
- Completion
- Sep 2027 (Estimated)
- Last update posted
- Sep 17, 2026
2024 – 2027
United States locations
- U.S. sites
- 31
- U.S. states
- 17
- U.S. cities
- 31
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Associated Retina Consultants | Phoenix | Arizona | 85020 | — |
| Barnet Dulaney Perkins Eye Center | Sun City | Arizona | 85351 | — |
| Retina Associates of Southern California | Huntington Beach | California | 92607 | — |
| Retina Consultants of San Diego | Poway | California | 92064 | — |
| Retinal Consultants Medical Group | Sacramento | California | 95825 | — |
| Orange County Retinal Medical Group | Santa Ana | California | 92705 | — |
| Bay Area Retina Associates | Walnut Creek | California | 94598 | — |
| Retina Consultants of Southern Colorado | Colorado Springs | Colorado | 80909 | — |
| Connecticut Eye Consultants, P.C. | Danbury | Connecticut | 06810 | — |
| Vitreo Retinal Associates | Gainesville | Florida | 32607 | — |
| Florida Retina Institute | Orlando | Florida | 32806 | — |
| Retina Vitreous Associates of Florida | St. Petersburg | Florida | 33711 | — |
| University Retina and Macula Associates | Oak Forest | Illinois | 60452 | — |
| Associated Vitreoretinal and Uveitis Consultants | Carmel | Indiana | 46290 | — |
| Mid Atlantic Retina Specialist | Hagerstown | Maryland | 21740 | — |
| Ophthalmic Consultants of Boston | Boston | Massachusetts | 02114 | — |
| Kellogg Eye Center | Ann Arbor | Michigan | 48105 | — |
| Retina Consultants of Minnesota | Minneapolis | Minnesota | 55435 | — |
| Mid Atlantic Retina | Cherry Hill | New Jersey | 08034 | — |
| NJ Retina | Teaneck | New Jersey | 07666 | — |
| Retina Vitreous Center | Edmond | Oklahoma | 73013 | — |
| Retina Northwest, PC | Portland | Oregon | 97221 | — |
| Retina Research Institute of Texas | Abilene | Texas | 79606 | — |
| Austin Clinical Research, LLC | Austin | Texas | 78750 | — |
| Retina Consultants of Texas | Bellaire | Texas | 77401 | — |
| Valley Retina Institute | McAllen | Texas | 78503 | — |
| Texas Retina Associates of Plano | Plano | Texas | 75075 | — |
| Medical Center Ophthalmology Associates | San Antonio | Texas | 78240 | — |
| Retina Consultants of Texas | The Woodlands | Texas | 77384 | — |
| Emerson Clinical Research Institute | Falls Church | Virginia | 22042 | — |
| Pacific Northwest Retina, PLLC | Silverdale | Washington | 98383 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 22 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06373731, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 17, 2026 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06373731 live on ClinicalTrials.gov.