ClinicalTrials.gov record
The CDK4/6 Inhibitor Dosing Knowledge (CDK) Study
ClinicalTrials.gov ID: NCT06377852
Public ClinicalTrials.gov record NCT06377852. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 8, 2026, 8:09 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Comparing Oral Drug Dosing Strategies in Older Patients With Metastatic Breast Cancer to Maximize Tolerance and Reduce Discontinuation: The CDK4/6 Inhibitor Dosing Knowledge (CDK) Study
Study identification
- NCT ID
- NCT06377852
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- American Society of Clinical Oncology
- Other
- Enrollment
- 500 participants
Conditions and interventions
Conditions
Interventions
- Palbociclib Drug
- Palbociclib 125mg Drug
- Ribociclib Drug
- Ribociclib 600mg Drug
Drug
Eligibility (public fields only)
- Age range
- 65 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 28, 2024
- Primary completion
- Aug 30, 2028
- Completion
- Aug 31, 2028
- Last update posted
- Mar 17, 2026
2024 – 2028
United States locations
- U.S. sites
- 67
- U.S. states
- 16
- U.S. cities
- 58
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Ironwood Cancer & Research Centers | Chandler | Arizona | 85224 | Recruiting |
| Ironwood Cancer & Research Centers | Gilbert | Arizona | 85297 | Recruiting |
| Ironwood Cancer & Research Centers | Glendale | Arizona | 85306 | Recruiting |
| Ironwood Cancer & Research Centers | Goodyear | Arizona | 85395 | Recruiting |
| Ironwood Cancer & Research Centers | Mesa | Arizona | 85202 | Recruiting |
| Ironwood Cancer & Research Centers | Mesa | Arizona | 85206 | Recruiting |
| Ironwood Cancer & Research Centers | Phoenix | Arizona | 85028 | Recruiting |
| Ironwood Cancer & Research Centers | Scottsdale | Arizona | 85260 | Recruiting |
| University of Colorado Anschutz Medical Campus | Aurora | Colorado | 80045 | Recruiting |
| UCHealth Cherry Creek Medical Center | Denver | Colorado | 80206 | Recruiting |
| UCHealth Highlands Ranch Hospital | Highlands Ranch | Colorado | 80129 | Recruiting |
| Smilow Cancer Hospital Care Center - Derby | Derby | Connecticut | 06418 | Recruiting |
| Smilow Cancer Hospital Care Center - Fairfield | Fairfield | Connecticut | 06824 | Recruiting |
| Smilow Cancer Hospital at Glastonbury | Glastonbury | Connecticut | 06033 | Recruiting |
| Smilow Cancer Hospital Care Center - Greenwich | Greenwich | Connecticut | 06830 | Recruiting |
| Smilow Cancer Hospital Care Center - Guilford | Guilford | Connecticut | 06437 | Recruiting |
| Smilow Cancer Hospital at Saint Francis | Hartford | Connecticut | 06105 | Recruiting |
| Smilow Cancer Hospital - Yale New Haven Health | New Haven | Connecticut | 06510 | Recruiting |
| Yale University/Yale Cancer Center/Yale School of Medicine | New Haven | Connecticut | 06510 | Recruiting |
| Smilow Cancer Hospital Care Center - North Haven | North Haven | Connecticut | 06473 | Recruiting |
| Smilow Cancer Hospital Care Center - Torrington | Torrington | Connecticut | 06790 | Recruiting |
| Smilow Cancer Hospital Care Center - Trumbull | Trumbull | Connecticut | 06611 | Recruiting |
| Smilow Cancer Hospital Care Center - Waterbury | Waterbury | Connecticut | 06708 | Recruiting |
| Smilow Cancer Hospital - Waterford | Waterford | Connecticut | 06385 | Recruiting |
| Miami Cancer Institute | Miami | Florida | 33176 | Recruiting |
| Miami Cancer Institute | Plantation | Florida | 33324 | Recruiting |
| Emory University Winship Cancer Institute | Atlanta | Georgia | 30322 | Recruiting |
| Lewis Cancer and Research Pavilion | Savannah | Georgia | 31405 | Recruiting |
| The University of Kansas Cancer Center | Westwood | Kansas | 66205 | Recruiting |
| The Jackson Laboratory (JAX) - Harold Alfond Center for Cancer Care | Augusta | Maine | 04330 | Recruiting |
| The Jackson Laboratory (JAX) - Northern Light Cancer Care | Brewer | Maine | 04412 | Recruiting |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | Recruiting |
| Dana-Farber Brigham Cancer Center Foxborough | Foxborough | Massachusetts | 02035 | Recruiting |
| Dana-Farber Cancer Institute Merrimack Valley | Methuen | Massachusetts | 01844 | Recruiting |
| Dana-Farber Brigham Cancer Center at Milford Regional Medical Center | Milford | Massachusetts | 01757 | Recruiting |
| Dana-Farber Brigham Cancer Center at South Shore Health | Weymouth | Massachusetts | 02190 | Recruiting |
| Dana-Farber/New Hampshire Oncology-Hematology | Londonderry | New Hampshire | 03053 | Recruiting |
| Penn Medicine - Princeton Health | Plainsboro | New Jersey | 08536 | Recruiting |
| Lovelace Medical Center - Saint Joseph Square | Albuquerque | New Mexico | 87102 | Recruiting |
| Lovelace Women's Hospital | Albuquerque | New Mexico | 87109 | Recruiting |
| Presbyterian Kaseman Hospital | Albuquerque | New Mexico | 87110 | Recruiting |
| The University of New Mexico Comprehensive Cancer Center | Albuquerque | New Mexico | 87131 | Recruiting |
| Memorial Medical Center | Las Cruces | New Mexico | 88011 | Recruiting |
| Presbyterian Rust Medical Center/Jorgensen Cancer Center | Rio Rancho | New Mexico | 87124 | Recruiting |
| Levine Cancer Institute | Albemarle | North Carolina | 28001 | Recruiting |
| Levine Cancer Institute | Charlotte | North Carolina | 28204 | Recruiting |
| Levine Cancer Institute | Charlotte | North Carolina | 28210 | Recruiting |
| Levine Cancer Institute | Charlotte | North Carolina | 28211 | Recruiting |
| Levine Cancer Institute | Charlotte | North Carolina | 28262 | Recruiting |
| Levine Cancer Institute | Charlotte | North Carolina | 28277 | Recruiting |
| Levine Cancer Institute | Concord | North Carolina | 28025 | Recruiting |
| Levine Cancer Institute | Forest City | North Carolina | 28043 | Recruiting |
| Levine Cancer Institute | Gastonia | North Carolina | 28054 | Recruiting |
| Levine Cancer Institute | Huntersville | North Carolina | 28078 | Recruiting |
| Levine Cancer Institute | Lincolnton | North Carolina | 28092 | Recruiting |
| Levine Cancer Institute | Matthews | North Carolina | 28104 | Recruiting |
| Levine Cancer Institute | Monroe | North Carolina | 28112 | Recruiting |
| Levine Cancer Institute | Shelby | North Carolina | 28150 | Recruiting |
| Penn Medicine - Lancaster General Hospital | Lancaster | Pennsylvania | 17601 | Recruiting |
| Penn Medicine - Perelman Center for Advanced Medicine | Philadelphia | Pennsylvania | 19104 | Recruiting |
| Penn Medicine - Pennsylvania Hospital | Philidelphia | Pennsylvania | 19106 | Recruiting |
| Penn Medicine - Chester County Hospital | West Chester | Pennsylvania | 19380 | Recruiting |
| Smilow Cancer Hospital - Westerly | Westerly | Rhode Island | 02891 | Recruiting |
| St. Joseph's Candler Bluffton Campus | Bluffton | South Carolina | 29910 | Recruiting |
| SC Cancer Specialists - Hilton Head at St. Joseph's/Candler | Hilton Head Island | South Carolina | 29926 | Recruiting |
| Levine Cancer Institute | Rock Hill | South Carolina | 29732 | Recruiting |
| Baptist Memorial Healthcare | Memphis | Tennessee | 38120 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06377852, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 17, 2026 · Synced May 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06377852 live on ClinicalTrials.gov.